email : cristine.goncalves[remplacer_par_at]cnrs-orleans.fr
Phone : +33 2.38.25.55.79
Engineer in biological techniques within the thematic group “Innovative therapies and nanomedecine“
- Filtres
Publications (Archives Hal)
Contact
isabelle.frapart@cnrs-orleans.fr
02.38.25.55.53
Disciplines
- Sciences du Vivant [q-bio]22
- Sciences du Vivant [q-bio]/Biochimie, Biologie Moléculaire3
- Chimie/Chimie organique1
- Chimie1
- Sciences de l'environnement/Biodiversité et Ecologie1
- Sciences du Vivant [q-bio]/Biochimie, Biologie Moléculaire/Biochimie [q-bio.BM]1
- Sciences du Vivant [q-bio]/Biochimie, Biologie Moléculaire/Biophysique1
- Sciences du Vivant [q-bio]/Biologie cellulaire/Organisation et fonctions cellulaires [q-bio.SC]1
- Sciences du Vivant [q-bio]/Biotechnologies1
- Sciences du Vivant [q-bio]/Sciences pharmaceutiques/Pharmacie galénique1
- Sciences du Vivant [q-bio]/Sciences pharmaceutiques/Pharmacologie1
- Sciences du Vivant [q-bio]/Sciences pharmaceutiques1
Mots-clefs
3′UTR 5′UTR ACTIVATION Amphiphilic polymer Anti-tumoral drugs Antisense oligonucleotides Archaeal trimannosyl lipid BINDING Bioproduction Bone morphogenetic protein 2 CFTR CRYSTAL-STRUCTURE Cancer therapy Cap Capping Endosome escape Gene transfer Histidine Liposomes Transfection
- Histidine3
- Endosome escape2
- Gene transfer2
- Liposomes2
- Transfection2
- 3′UTR1
- 5′UTR1
- ACTIVATION1
- Amphiphilic polymer1
- Anti-tumoral drugs1
- Antisense oligonucleotides1
- Archaeal trimannosyl lipid1
- BINDING1
- Bioproduction1
- Bone morphogenetic protein 21
- CFTR1
- CRYSTAL-STRUCTURE1
- Cancer therapy1
- Cap1
- Capping1
- Cationic lipids1
- Cationic polymers1
- Chinese hamster ovary cells1
- Co-delivery1
- Curcumin1
- Cystic fibrosis1
- Cytosolic delivery1
- DELIVERY1
- DNA-protein interaction1
- Dendritic cell binding1
- Dendritic cells1
- Dynein1
- FIP-11
- Fusogenic peptide1
- Gene delivery1
- Gene expression1
- IN-VIVO1
- Intracellular transport1
- LIVING CELLS1
- Lentivirus1
- Lipofection1
- MRNA1
- MRNA delivery1
- MRNA transfection1
- MRNA transfer1
- Mannose receptor1
- Micellar carriers1
- Microtubules1
- Minicircle DNA1
- NANOPARTICLES1
- NF kappa B1
- Non-structural protein 11
- Non-viral gene vectors1
- Non-viral vector1
- Nonviral vector1
- Osteogenesis1
- Plasmid nuclear import TRANSGENE EXPRESSION1
- PolyA chains1
- Polyallylamine1
- Polymer1
- RECOGNITION1
- RNA1
- RNA interference1
- RNA sensors1
- Splicing1
- TRANSFECTION1
- Transfection efficiency1
- Triblock copolymer1
Auteurs
Midoux Patrick27
Pichon Chantal25
Gonçalves Cristine21
Guégan Philippe7
Cheradame Hervé6
Pichon C.5
Goncalves Cristine5
Midoux P.5
Delehedde C3
Jaffres Paul-Alain3
Malard Virginie3
Goncalves C.3
Gonçalves C.3
Pigeon Lucie3
Dréan Mathilde2
Gomez Jean-Pierre2
Guérin Brigitte2
Lehn Pierre2
Pavloska I.2
Pigeon L.2
Rameix N2
Rasolonjatovo Bazoly2
Wang Pinpin2
Gosset David2
Perche Federico2
Gonçalves Christine2
Même William2
Breuzard Gilles2
Rieger Jutta2
Montier Tristan2
Debuigne Antoine2
Huin Cécile2
Jérôme Christine2
Akhter Sohail1
Ardourel Maryvonne1
Asseline Ulysse1
Barbeau J.1
Bennevault-Celton Véronique1
Benvegnu T.1
Berchel M.1
Bertrand Emilie1
Billiet Ludivine1
Cendret Virginie1
Chaudhuri A.1
Correia Ilídio J.1
Costa Elisabete C.1
Dias Figueiredo H.1
Dupuy F.P.1
Duque A.P.1
Even L1
Even L.1
Fuchs R.1
Gallego Téo1
Gao H1
Gao H.1
Gao Haifei1
Gaspar Vítor M.1
Godin F1
Gomez Jean Pierre1
Gomez Pierre1
Gosselin Marie-Pierre1
Gross Fabian1
Guilherme P.1
Géguan Philippe1
Haifei G1
Hulin Philippe1
J.P. Gorvel1
Kepczynski Mariusz1
Laroui N1
Leduc Chloe1
Lemoine F.M.1
Lemoine François M1
Logeart Delphine1
Malard V.1
Martins A.C.1
Mateo Véronique1
Maury Benoit1
Mennesson E.1
Mevel M.1
Mockey M.1
Morais M.1
Nedellec Steven1
Neveu C.1
Nowakowska Maria1
Perche F1
Petite Hervé1
Pinto P.1
Queiroz João A.1
Quelen A.1
Sandrin P.1
Santo M.1
Sarna Michal1
Singh R.S.1
Sousa Fani1
Tertil Magdalena1
Vigny Paul1
Wytrwal Magdalena1
Yaouanc J.-J.1
Zeghal Mehdi1
de Melo-Diogo Duarte1
Revues
- The Journal of Gene Medicine4
- Biomacromolecules2
- Carbohydrate Research2
- Chemical Communications2
- International Journal of Pharmaceutics2
- Biochemical and Biophysical Research Communications1
- Biomaterials1
- Bioscience Reports1
- Biotechnology Journal1
- European Journal of Pharmaceutics and Biopharmaceutics1
- Gene Therapy1
- Journal of Controlled Release1
- SIL Proceedings: Internationale Vereinigung für Theoretische und Angewandte Limnologie: Verhandlungen1
- Macromolecular Bioscience1
- Molecular Pharmaceutics1
- Molecular Therapy1
- Nucleic Acids Research1
- Small1
- Soft Matter1
- Chemistry & biology1
- Acta Biomaterialia1
- Advanced Drug Delivery Reviews1
Institutions
- Université d'Orléans34
- Institut National de la Santé et de la Recherche Médicale34
- Institut de Chimie du CNRS34
- Université Pierre et Marie Curie - Paris 67
- Commissariat à l'énergie atomique et aux énergies alternatives6
- Université de Cergy Pontoise6
- Université d'Évry-Val-d'Essonne6
- Université de Brest5
- Université Paris Diderot - Paris 72
- Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture2
- Université de Liège2
- Université de Rennes1
- Institut National des Sciences Appliquées - Rennes1
- Institut Ecologie et Environnement1
- Institut national des sciences de l'Univers1
- Centre Hospitalier Universitaire de Toulouse1
- EFS1
- Université de Picardie Jules Verne1
- Ecole Nationale Supérieure de Chimie de Paris - Chimie ParisTech-PSL1
- Ecole Nationale Supérieure de Chimie de Rennes1
- Ecole Superieure de Physique et de Chimie Industrielles de la Ville de Paris1
- Uniwersytet Jagielloński w Krakowie = Jagiellonian University1
- École nationale vétérinaire - Alfort1
- Université de Lorraine1
- Université Paris-Est Créteil Val-de-Marne - Paris 121
- Jagiellonan University1
- University of Beira Interior [Portugal]1
- Université Paris Saclay (COmUE)1
- École normale supérieure - Paris1
- Université Paris-Sud - Paris 111
- Université de Nantes1
Laboratoires
- Centre de biophysique moléculaire34
- Institut Parisien de Chimie Moléculaire6
- Laboratoire Analyse et Modélisation pour la Biologie et l'Environnement5
- Chimie, Electrochimie Moléculaires et Chimie Analytique3
- NANTES METROPOLE FRA2
- Institut de Biologie et Chimie des Protéines1
- Biologie et thérapeutique des pathologies immunitaires1
- Laboratoire Analyse et Modélisation pour la Biologie et l'Environnement1
- Faculty of Chemistry1
- Laboratoire de Physique des Solides1
- Bioingénierie et Bioimagerie Ostéo-articulaires ; Biomécanique et Biomatériaux Ostéo-Articulaires1
- Génétique, génomique fonctionnelle et biotechnologies (UMR 1078)1
- Institut des Sciences Chimiques de Rennes1
- Laboratoire Matériaux Polymères aux Interfaces1
- Laboratoire Interdisciplinaire des Environnements Continentaux1
- INSERM U613, IFR1481
- Département d'Informatique et de Recherche Opérationnelle [Montreal]1
- academic center for materials and nanotechnology1
- Plateforme MicroPicell [Nantes]1
- Laboratoire de Glycochimie, des Antimicrobiens et des Agro-ressources - UMR CNRS 73781
- Laboratoire de biochimie théorique [Paris]1
- Centre d'Immunologie et des Maladies Infectieuses1
- Institut Parisien de Chimie Moléculaire1
- Centre d'Etude et de Recherche sur les Macromolécules1
- Center for Education and Research on Macromolecules1
Départements
Équipes de recherche
35 documents
Article dans une revue29 documents
- Pinpin Wang, Delphine Logeart-Avramoglou, Hervé Petite, Cristine Gonçalves, Patrick Midoux, et al.. Co-delivery of NS1 and BMP2 mRNAs to murine pluripotent stem cells leads to enhanced BMP-2 expression and osteogenic differentiation. Acta Biomaterialia, 2020, 108, pp.337-346. ⟨10.1016/j.actbio.2020.03.045⟩. ⟨hal-02553030⟩
- Haifei Gao, Cristine Goncalves, Téo Gallego, Marc Francois-Heude, Virginie Malard, et al.. Comparative binding and uptake of liposomes decorated with mannose oligosaccharides by cells expressing the mannose receptor or DC-SIGN. Carbohydrate Research, 2020, 487, pp.107877. ⟨10.1016/j.carres.2019.107877⟩. ⟨hal-02522179⟩
- Mathilde Dréan, Antoine Debuigne, Christine Jérôme, Cristine Gonçalves, Patrick Midoux, et al.. Poly( N -methylvinylamine)-based copolymers for improved gene transfection. Macromolecular Bioscience, 2018, 18 (4), pp.1700353. ⟨10.1002/mabi.201700353⟩. ⟨hal-01966107⟩
- Patrick Midoux, Lucie Pigeon, Cristine Goncalves, Chantal Pichon. Peptides mediating DNA transport on microtubules and their impact on non-viral gene transfer efficiency. Bioscience Reports, 2017, 37 (5), pp.BSR20170995. ⟨10.1042/BSR20170995⟩. ⟨hal-02068759⟩
- Cristine Gonçalves, Pierre Gomez, William Même, Bazoly Rasolonjatovo, David Gosset, et al.. Curcumin/poly(2-methyl-2-oxazoline-b-tetrahydrofuran-b-2-methyl-2-oxazoline) formulation: An improved penetration and biological effect of curcumin in F508del-CFTR cell lines. European Journal of Pharmaceutics and Biopharmaceutics, 2017, 117, pp.168-181. ⟨10.1016/j.ejpb.2017.04.015⟩. ⟨hal-01618274⟩
- Mathilde Dréan, Antoine Debuigne, Cristine Gonçalves, Christine Jérôme, Patrick Midoux, et al.. Use of Primary and Secondary Polyvinylamines for Efficient Gene Transfection. Biomacromolecules, 2017, 18 (2), pp.440-451. ⟨10.1021/acs.biomac.6b01526⟩. ⟨hal-01427315⟩
- Jean-Pierre Gomez, Cristine Gonçalves, Chantal Pichon, Patrick Midoux. Effect of IL-1β, TNF-α and IGF-1 on trans-endothelial passage of synthetic vectors through an in vitro vascular endothelial barrier of striated muscle. Gene Therapy, 2017, 24 (7), pp.416 - 424. ⟨10.1038/gt.2017.40⟩. ⟨hal-01618260⟩
- L. Pigeon, C. Gonçalves, C. Pichon, P. Midoux. Evidence for plasmid DNA exchange after polyplex mixing. Soft Matter, 2016, 12 (33), pp.7012-7019. ⟨10.1039/c6sm00575f⟩. ⟨hal-02069106⟩
- J. Barbeau, L. Lemiègre, A. Quelen, V. Malard, H. Gao, et al.. Synthesis of a trimannosylated-equipped archaeal diether lipid for the development of novel glycoliposomes. Carbohydrate Research, 2016, 435, pp.142--148. ⟨10.1016/j.carres.2016.10.003⟩. ⟨hal-01398046⟩
- Cristine Goncalves, Sohail Akhter, Chantal Pichon, Patrick Midoux. Intracellular Availability of pDNA and mRNA after Transfection: A Comparative Study among Polyplexes, Lipoplexes, and Lipopolyplexes. Molecular Pharmaceutics, 2016, 13 (9), pp.3153-3163. ⟨10.1021/acs.molpharmaceut.6b00376⟩. ⟨hal-02069071⟩
- Magdalena Wytrwal, Chloe Leduc, Michal Sarna, Cristine Goncalves, Mariusz Kepczynski, et al.. Gene delivery efficiency and intracellular trafficking of novel poly(allylamine) derivatives. International Journal of Pharmaceutics, 2015, 478 (1), pp.372-382. ⟨10.1016/j.ijpharm.2014.11.053⟩. ⟨hal-01172009⟩
- Bazoly Rasolonjatovo, Jean-Pierre Gomez, William Même, Cristine Gonçalves, Cécile Huin, et al.. Poly(2-methyl-2-oxazoline)-b-poly(tetrahydrofuran)-b-poly(2-methyl-2-oxazoline) Amphiphilic Triblock Copolymers: Synthesis, Physicochemical Characterizations, and Hydrosolubilizing Properties. Biomacromolecules, 2015, 16 (3), pp.748-756. ⟨10.1021/bm5016656⟩. ⟨hal-01171865⟩
- Vítor M. Gaspar, Cristine Gonçalves, Duarte de Melo-Diogo, Elisabete C. Costa, João A. Queiroz, et al.. Poly(2-ethyl-2-oxazoline)–PLA-g–PEI amphiphilic triblock micelles for co-delivery of minicircle DNA and chemotherapeutics. Journal of Controlled Release, 2014, 189, pp.90-104. ⟨10.1016/j.jconrel.2014.06.040⟩. ⟨hal-01179020⟩
- Ulysse Asseline, Cristine Gonçalves, Chantal Pichon, Patrick Midoux. Improved nuclear delivery of antisense 2′-Ome RNA by conjugation with the histidine-rich peptide H5WYG. The Journal of Gene Medicine, 2014, 16 (7-8), pp.157-165. ⟨10.1002/jgm.2773⟩. ⟨hal-01175483⟩
- Benoit Maury, Cristine Gonçalves, Guillaume Tresset, Mehdi Zeghal, Hervé Cheradame, et al.. Influence of pDNA availability on transfection efficiency of polyplexes in non-proliferative cells.. Biomaterials, 2014, 35 (22), pp.5977-5985. ⟨10.1016/j.biomaterials.2014.04.007⟩. ⟨hal-01179393⟩
- Cristine Gonçalves, Mathieu Berchel, Marie-Pierre Gosselin, Virginie Malard, Hervé Cheradame, et al.. Lipopolyplexes comprising imidazole/imidazolium lipophosphoramidate, histidinylated polyethyleneimine and siRNA as efficient formulation for siRNA transfection. International Journal of Pharmaceutics, 2014, 460 (1-2), pp.264-272. ⟨10.1016/j.ijpharm.2013.11.005⟩. ⟨hal-01179049⟩
- Cristine Gonçalves, Fabian Gross, Philippe Guégan, Hervé Cheradame, Patrick Midoux. A robust transfection reagent for the transfection of CHO and HEK293 cells and production of recombinant proteins and lentiviral particles - PTG1. Biotechnology Journal, 2014, 9 (11), pp.1380-1388. ⟨10.1002/biot.201400324⟩. ⟨hal-01179065⟩
- Lucie Pigeon, Cristine Gonçalves, David Gosset, Chantal Pichon, Patrick Midoux. An E3-14.7K Peptide that Promotes Microtubules-Mediated Transport of Plasmid DNA Increases Polyplexes Transfection Efficiency.. Small, 2013, 9 (22), pp.3845-3851. ⟨10.1002/smll.201300217⟩. ⟨hal-00840172⟩
- Emilie Bertrand, Cristine Gonçalves, Ludivine Billiet, Jean Pierre Gomez, Chantal Pichon, et al.. Histidinylated linear PEI: a new efficient non-toxic polymer for gene transfer.. Chemical Communications, 2011, 47 (46), pp.12547-12549. ⟨10.1039/c1cc15716g⟩. ⟨hal-00720539⟩
- Cristine Gonçalves, Maryvonne Ardourel, Martine Decoville, Gilles Breuzard, Patrick Midoux, et al.. An optimized extended DNA kappa B site that enhances plasmid DNA nuclear import and gene expression. The Journal of Gene Medicine, 2009, 11 (5), pp.401-411. ⟨10.1002/jgm.1312⟩. ⟨hal-00522437⟩
- P. Pinto, M. Morais, P. Usseglio-Polatera, H. Dias Figueiredo, A.C. Martins, et al.. Seasonal and spatial gradients in the biological and ecological traits of benthic macroinvertebrate communities in Mediterranean rivers in southern Portugal. SIL Proceedings: Internationale Vereinigung für Theoretische und Angewandte Limnologie: Verhandlungen , 2009, 30 (8), pp.1197-1201. ⟨10.1080/03680770.2009.11923911⟩. ⟨hal-03102281⟩
- Gilles Breuzard, Magdalena Tertil, Cristine Gonçalves, Hervé Cheradame, Philippe Géguan, et al.. Nuclear delivery of NFkappaB-assisted DNA/polymer complexes: plasmid DNA quantitation by confocal laser scanning microscopy and evidence of nuclear polyplexes by FRET imaging.. Nucleic Acids Research, 2008, 36 (12), pp.e71. ⟨10.1093/nar/gkn287⟩. ⟨hal-00408004⟩
- M. Mevel, C. Neveu, Cristine Goncalves, J.-J. Yaouanc, Chantal Pichon, et al.. Novel neutral imidazole-lipophosphoramides for transfection assays. Chemical Communications, 2008, 27, pp.3124-3126. ⟨10.1039/b805226c⟩. ⟨hal-00518192⟩
- M. Mockey, C. Goncalves, F.P. Dupuy, F.M. Lemoine, C. Pichon, et al.. mRNA transfection of dendritic cells: synergistic effect of ARCA mRNA capping with Poly(A) chains in cis and in trans for a high protein expression level. Biochemical and Biophysical Research Communications, 2006, 340, pp.1062-1068. ⟨10.1016/j.bbrc.2005.12.105⟩. ⟨hal-00088921⟩
- C. Goncalves, E. Mennesson, R. Fuchs, Gorvel J.P., Patrick Midoux, et al.. Macropinocytosis of polyplexes and recycling of plasmid via the clathrin-dependant pathway impair the transfection efficiency into human hepatocarcinoma cells. Molecular Therapy, 2004, 10, pp.373-385. ⟨hal-00113047⟩
- R.S. Singh, C. Gonçalves, P. Sandrin, C. Pichon, P. Midoux, et al.. On the gene delivery efficacies of pH-sensitive cationic lipids via endosomal protonation: a chemical biology investigation. Chemistry & biology, 2004, 11, pp.713-723. ⟨hal-00088426⟩
- Chantal Pichon, Brigitte Guérin, Matthieu M. Refregiers, Christine Gonçalves, Paul Vigny, et al.. Zinc improves gene transfer mediated by DNA/cationic polymer complexes. The Journal of Gene Medicine, 2002, 4 (5), pp.548 - 559. ⟨10.1002/jgm.303⟩. ⟨hal-01596013⟩
- Christine Gonçalves, Chantal Pichon, Brigitte Guérin, Patrick Midoux. Intracellular processing and stability of DNA complexed with histidylated polylysine conjugates. The Journal of Gene Medicine, 2002, 4 (3), pp.271-281. ⟨10.1002/jgm.277⟩. ⟨hal-02135970⟩
- Chantal Pichon, C Gonçalves, P. Midoux. Histidine-rich peptides and polymers for nucleic acids delivery.. Advanced Drug Delivery Reviews, 2001, 53 (1), pp.75-94. ⟨hal-02135973⟩
Poster6 documents
- N Laroui, C Delehedde, Cristine Gonçalves, F Godin, F Perche, et al.. High Efficiency of Histidylated-based Lipid Formulations for mRNA Transfection of Human Schwann Cells. 10th mRNA Health Conference, Nov 2021, Berlin, Germany. ⟨hal-03668434⟩
- C Delehedde, G Haifei, Cristine Gonçalves, Virginie Malard, N Rameix, et al.. Influence of the charge of mRNA mannosylated lipopolyplexes on the binding and uptake by dendritic cells. 33e colloque Biotechnocentre, Oct 2021, Seillac, France. ⟨hal-03668442⟩
- C Delehedde, H Gao, Cristine Gonçalves, V. Malard, N Rameix, et al.. Influence of the charge if mRNA-mannosylated lipopolyplexes on the binding and the uptake of dendritic cells. mRNA Health Conference 2020, Nov 2020, Boston (Virtual), United States. ⟨hal-03668576⟩
- Pinpin Wang, Delphine Logeart, Lucie Pigeon, Cristine Gonçalves, Hervé Petite, et al.. Improved osteogenic commitment of BMP2 mRNA-transfected MSCs using NS1 mRNA. ASGCT 2019, Apr 2020, Washington, United States. ⟨hal-03668438⟩
- I. Pavloska, Cristine Gonçalves, Patrick Midoux, Chantal Pichon. Intracellular routing of mRNA lipoplexes in dendritic cells.. Studium Conférence, Mar 2017, Orléans, France. ⟨hal-03668580⟩
- L. Pigeon, I. Pavloska, Cristine Gonçalves, Patrick Midoux, Chantal Pichon. Intracellular routing of mRNA lipoplexes in dendritic cells. ASGCT 2017, May 2017, Washington, United States. ⟨hal-03680369⟩