email : cristine.goncalves[remplacer_par_at]cnrs-orleans.fr

Phone : +33

Engineer in biological techniques within the thematic group Innovative therapies and nanomedecine


35 documents

Article dans une revue

  • Pinpin Wang, Delphine Logeart-Avramoglou, Hervé Petite, Cristine Gonçalves, Patrick Midoux, et al.. Co-delivery of NS1 and BMP2 mRNAs to murine pluripotent stem cells leads to enhanced BMP-2 expression and osteogenic differentiation. Acta Biomaterialia, 2020, 108, pp.337-346. ⟨10.1016/j.actbio.2020.03.045⟩. ⟨hal-02553030⟩
  • Haifei Gao, Cristine Goncalves, Téo Gallego, Marc Francois-Heude, Virginie Malard, et al.. Comparative binding and uptake of liposomes decorated with mannose oligosaccharides by cells expressing the mannose receptor or DC-SIGN. Carbohydrate Research, 2020, 487, pp.107877. ⟨10.1016/j.carres.2019.107877⟩. ⟨hal-02522179⟩
  • Mathilde Dréan, Antoine Debuigne, Christine Jérôme, Cristine Gonçalves, Patrick Midoux, et al.. Poly( N -methylvinylamine)-based copolymers for improved gene transfection. Macromolecular Bioscience, 2018, 18 (4), pp.1700353. ⟨10.1002/mabi.201700353⟩. ⟨hal-01966107⟩
  • Patrick Midoux, Lucie Pigeon, Cristine Goncalves, Chantal Pichon. Peptides mediating DNA transport on microtubules and their impact on non-viral gene transfer efficiency. Bioscience Reports, 2017, 37 (5), pp.BSR20170995. ⟨10.1042/BSR20170995⟩. ⟨hal-02068759⟩
  • Cristine Gonçalves, Pierre Gomez, William Même, Bazoly Rasolonjatovo, David Gosset, et al.. Curcumin/poly(2-methyl-2-oxazoline-b-tetrahydrofuran-b-2-methyl-2-oxazoline) formulation: An improved penetration and biological effect of curcumin in F508del-CFTR cell lines. European Journal of Pharmaceutics and Biopharmaceutics, 2017, 117, pp.168-181. ⟨10.1016/j.ejpb.2017.04.015⟩. ⟨hal-01618274⟩
  • Mathilde Dréan, Antoine Debuigne, Cristine Gonçalves, Christine Jérôme, Patrick Midoux, et al.. Use of Primary and Secondary Polyvinylamines for Efficient Gene Transfection. Biomacromolecules, 2017, 18 (2), pp.440-451. ⟨10.1021/acs.biomac.6b01526⟩. ⟨hal-01427315⟩
  • Jean-Pierre Gomez, Cristine Gonçalves, Chantal Pichon, Patrick Midoux. Effect of IL-1β, TNF-α and IGF-1 on trans-endothelial passage of synthetic vectors through an in vitro vascular endothelial barrier of striated muscle. Gene Therapy, 2017, 24 (7), pp.416 - 424. ⟨10.1038/gt.2017.40⟩. ⟨hal-01618260⟩
  • L. Pigeon, C. Gonçalves, C. Pichon, P. Midoux. Evidence for plasmid DNA exchange after polyplex mixing. Soft Matter, 2016, 12 (33), pp.7012-7019. ⟨10.1039/c6sm00575f⟩. ⟨hal-02069106⟩
  • J. Barbeau, L. Lemiègre, A. Quelen, V. Malard, H. Gao, et al.. Synthesis of a trimannosylated-equipped archaeal diether lipid for the development of novel glycoliposomes. Carbohydrate Research, 2016, 435, pp.142--148. ⟨10.1016/j.carres.2016.10.003⟩. ⟨hal-01398046⟩
  • Cristine Goncalves, Sohail Akhter, Chantal Pichon, Patrick Midoux. Intracellular Availability of pDNA and mRNA after Transfection: A Comparative Study among Polyplexes, Lipoplexes, and Lipopolyplexes. Molecular Pharmaceutics, 2016, 13 (9), pp.3153-3163. ⟨10.1021/acs.molpharmaceut.6b00376⟩. ⟨hal-02069071⟩
  • Magdalena Wytrwal, Chloe Leduc, Michal Sarna, Cristine Goncalves, Mariusz Kepczynski, et al.. Gene delivery efficiency and intracellular trafficking of novel poly(allylamine) derivatives. International Journal of Pharmaceutics, 2015, 478 (1), pp.372-382. ⟨10.1016/j.ijpharm.2014.11.053⟩. ⟨hal-01172009⟩
  • Bazoly Rasolonjatovo, Jean-Pierre Gomez, William Même, Cristine Gonçalves, Cécile Huin, et al.. Poly(2-methyl-2-oxazoline)-b-poly(tetrahydrofuran)-b-poly(2-methyl-2-oxazoline) Amphiphilic Triblock Copolymers: Synthesis, Physicochemical Characterizations, and Hydrosolubilizing Properties. Biomacromolecules, 2015, 16 (3), pp.748-756. ⟨10.1021/bm5016656⟩. ⟨hal-01171865⟩
  • Vítor M. Gaspar, Cristine Gonçalves, Duarte de Melo-Diogo, Elisabete C. Costa, João A. Queiroz, et al.. Poly(2-ethyl-2-oxazoline)–PLA-g–PEI amphiphilic triblock micelles for co-delivery of minicircle DNA and chemotherapeutics. Journal of Controlled Release, 2014, 189, pp.90-104. ⟨10.1016/j.jconrel.2014.06.040⟩. ⟨hal-01179020⟩
  • Ulysse Asseline, Cristine Gonçalves, Chantal Pichon, Patrick Midoux. Improved nuclear delivery of antisense 2′-Ome RNA by conjugation with the histidine-rich peptide H5WYG. The Journal of Gene Medicine, 2014, 16 (7-8), pp.157-165. ⟨10.1002/jgm.2773⟩. ⟨hal-01175483⟩
  • Benoit Maury, Cristine Gonçalves, Guillaume Tresset, Mehdi Zeghal, Hervé Cheradame, et al.. Influence of pDNA availability on transfection efficiency of polyplexes in non-proliferative cells.. Biomaterials, 2014, 35 (22), pp.5977-5985. ⟨10.1016/j.biomaterials.2014.04.007⟩. ⟨hal-01179393⟩
  • Cristine Gonçalves, Mathieu Berchel, Marie-Pierre Gosselin, Virginie Malard, Hervé Cheradame, et al.. Lipopolyplexes comprising imidazole/imidazolium lipophosphoramidate, histidinylated polyethyleneimine and siRNA as efficient formulation for siRNA transfection. International Journal of Pharmaceutics, 2014, 460 (1-2), pp.264-272. ⟨10.1016/j.ijpharm.2013.11.005⟩. ⟨hal-01179049⟩
  • Cristine Gonçalves, Fabian Gross, Philippe Guégan, Hervé Cheradame, Patrick Midoux. A robust transfection reagent for the transfection of CHO and HEK293 cells and production of recombinant proteins and lentiviral particles - PTG1. Biotechnology Journal, 2014, 9 (11), pp.1380-1388. ⟨10.1002/biot.201400324⟩. ⟨hal-01179065⟩
  • Lucie Pigeon, Cristine Gonçalves, David Gosset, Chantal Pichon, Patrick Midoux. An E3-14.7K Peptide that Promotes Microtubules-Mediated Transport of Plasmid DNA Increases Polyplexes Transfection Efficiency.. Small, 2013, 9 (22), pp.3845-3851. ⟨10.1002/smll.201300217⟩. ⟨hal-00840172⟩
  • Emilie Bertrand, Cristine Gonçalves, Ludivine Billiet, Jean Pierre Gomez, Chantal Pichon, et al.. Histidinylated linear PEI: a new efficient non-toxic polymer for gene transfer.. Chemical Communications, 2011, 47 (46), pp.12547-12549. ⟨10.1039/c1cc15716g⟩. ⟨hal-00720539⟩
  • Cristine Gonçalves, Maryvonne Ardourel, Martine Decoville, Gilles Breuzard, Patrick Midoux, et al.. An optimized extended DNA kappa B site that enhances plasmid DNA nuclear import and gene expression. The Journal of Gene Medicine, 2009, 11 (5), pp.401-411. ⟨10.1002/jgm.1312⟩. ⟨hal-00522437⟩
  • P. Pinto, M. Morais, P. Usseglio-Polatera, H. Dias Figueiredo, A.C. Martins, et al.. Seasonal and spatial gradients in the biological and ecological traits of benthic macroinvertebrate communities in Mediterranean rivers in southern Portugal. SIL Proceedings: Internationale Vereinigung für Theoretische und Angewandte Limnologie: Verhandlungen , 2009, 30 (8), pp.1197-1201. ⟨10.1080/03680770.2009.11923911⟩. ⟨hal-03102281⟩
  • Gilles Breuzard, Magdalena Tertil, Cristine Gonçalves, Hervé Cheradame, Philippe Géguan, et al.. Nuclear delivery of NFkappaB-assisted DNA/polymer complexes: plasmid DNA quantitation by confocal laser scanning microscopy and evidence of nuclear polyplexes by FRET imaging.. Nucleic Acids Research, 2008, 36 (12), pp.e71. ⟨10.1093/nar/gkn287⟩. ⟨hal-00408004⟩
  • M. Mevel, C. Neveu, Cristine Goncalves, J.-J. Yaouanc, Chantal Pichon, et al.. Novel neutral imidazole-lipophosphoramides for transfection assays. Chemical Communications, 2008, 27, pp.3124-3126. ⟨10.1039/b805226c⟩. ⟨hal-00518192⟩
  • M. Mockey, C. Goncalves, F.P. Dupuy, F.M. Lemoine, C. Pichon, et al.. mRNA transfection of dendritic cells: synergistic effect of ARCA mRNA capping with Poly(A) chains in cis and in trans for a high protein expression level. Biochemical and Biophysical Research Communications, 2006, 340, pp.1062-1068. ⟨10.1016/j.bbrc.2005.12.105⟩. ⟨hal-00088921⟩
  • C. Goncalves, E. Mennesson, R. Fuchs, Gorvel J.P., Patrick Midoux, et al.. Macropinocytosis of polyplexes and recycling of plasmid via the clathrin-dependant pathway impair the transfection efficiency into human hepatocarcinoma cells. Molecular Therapy, 2004, 10, pp.373-385. ⟨hal-00113047⟩
  • R.S. Singh, C. Gonçalves, P. Sandrin, C. Pichon, P. Midoux, et al.. On the gene delivery efficacies of pH-sensitive cationic lipids via endosomal protonation: a chemical biology investigation. Chemistry & biology, 2004, 11, pp.713-723. ⟨hal-00088426⟩
  • Chantal Pichon, Brigitte Guérin, Matthieu M. Refregiers, Christine Gonçalves, Paul Vigny, et al.. Zinc improves gene transfer mediated by DNA/cationic polymer complexes. The Journal of Gene Medicine, 2002, 4 (5), pp.548 - 559. ⟨10.1002/jgm.303⟩. ⟨hal-01596013⟩
  • Christine Gonçalves, Chantal Pichon, Brigitte Guérin, Patrick Midoux. Intracellular processing and stability of DNA complexed with histidylated polylysine conjugates. The Journal of Gene Medicine, 2002, 4 (3), pp.271-281. ⟨10.1002/jgm.277⟩. ⟨hal-02135970⟩
  • Chantal Pichon, C Gonçalves, P. Midoux. Histidine-rich peptides and polymers for nucleic acids delivery.. Advanced Drug Delivery Reviews, 2001, 53 (1), pp.75-94. ⟨hal-02135973⟩


  • N Laroui, C Delehedde, Cristine Gonçalves, F Godin, F Perche, et al.. High Efficiency of Histidylated-based Lipid Formulations for mRNA Transfection of Human Schwann Cells. 10th mRNA Health Conference, Nov 2021, Berlin, Germany. ⟨hal-03668434⟩
  • C Delehedde, G Haifei, Cristine Gonçalves, Virginie Malard, N Rameix, et al.. Influence of the charge of mRNA mannosylated lipopolyplexes on the binding and uptake by dendritic cells. 33e colloque Biotechnocentre, Oct 2021, Seillac, France. ⟨hal-03668442⟩
  • C Delehedde, H Gao, Cristine Gonçalves, V. Malard, N Rameix, et al.. Influence of the charge if mRNA-mannosylated lipopolyplexes on the binding and the uptake of dendritic cells. mRNA Health Conference 2020, Nov 2020, Boston (Virtual), United States. ⟨hal-03668576⟩
  • Pinpin Wang, Delphine Logeart, Lucie Pigeon, Cristine Gonçalves, Hervé Petite, et al.. Improved osteogenic commitment of BMP2 mRNA-transfected MSCs using NS1 mRNA. ASGCT 2019, Apr 2020, Washington, United States. ⟨hal-03668438⟩
  • I. Pavloska, Cristine Gonçalves, Patrick Midoux, Chantal Pichon. Intracellular routing of mRNA lipoplexes in dendritic cells.. Studium Conférence, Mar 2017, Orléans, France. ⟨hal-03668580⟩
  • L. Pigeon, I. Pavloska, Cristine Gonçalves, Patrick Midoux, Chantal Pichon. Intracellular routing of mRNA lipoplexes in dendritic cells. ASGCT 2017, May 2017, Washington, United States. ⟨hal-03680369⟩