email : alain.legrand@cnrs-orleans.fr

Phone : +33

Office A114

Professor, co-responsible of the thematic group “Cell signalling”


11 documents


  • Amandine Serrano, Saïd El Haddad, Fréderic Moal, Thierry Prazuck, Eric Legac, et al.. Dysregulation of apoptosis and autophagy gene expression in peripheral blood mononuclear cells of efficiently treated HIV-infected patients. AIDS, Lippincott, Williams & Wilkins, 2018, 32 (12), pp.1579 - 1587. ⟨10.1097/QAD.0000000000001851⟩. ⟨hal-01936094⟩
  • Kévin Moreau, Justine Surand, Aurélia Le Dantec, Christine Mosrin-Huaman, Alain Legrand, et al.. Recombinant yeast and human cells as screening tools to search for antibacterial agents targeting the transcription termination factor Rho. Journal of Antibiotics, Nature Publishing Group: Open Access Hybrid Model Option B, 2018, 71 (4), pp.447-455. 〈hal-01966171〉
  • Saïd El Haddad, Amandine Serrano, Thierry Normand, Chloé Robin, Martine Dubois, et al.. Interaction of Alpha-synuclein with Cytogaligin, a protein encoded by the proapoptotic gene GALIG. Biochemical and Biophysical Research Communications, Elsevier, 2018, 495 (1), pp.787-792. 〈hal-01966108〉
  • 2013

  • Lucile Mollet, Pauline Robinet, Martine Dubois, Axel Aurouet, Thierry Normand, et al.. Opposing Mcl-1, the GALIG proapoptotic gene is upregulated as neutrophils die and underexpressed in Acute Myeloid Leukemia cells.. Molecular Immunology, Elsevier, 2013, 56 (1-2), pp.123-8. ⟨10.1016/j.molimm.2013.04.012⟩. ⟨hal-00840170⟩
  • Emeric Gueneau, Claudine Dherin, Pierre Legrand, Carine Tellier-Lebegue, Bernard Gilquin, et al.. Structure of the MutLα C-terminal domain reveals how Mlh1 contributes to Pms1 endonuclease site.. Nature Structural and Molecular Biology, Nature Publishing Group, 2013, 20 (4), pp.461-8. ⟨10.1038/nsmb.2511⟩. ⟨hal-00817454⟩
  • Violette Senille, Dominique Lelievre, Françoise Paquet, Norbert Garnier, Ned Lamb, et al.. The addressing fragment of mitogaligin: first insights into functional and structural properties.. ChemBioChem, Wiley-VCH Verlag, 2013, 14 (6), pp.711-20. 〈10.1002/cbic.201200715〉. 〈hal-00817503〉
  • 2010

  • Pauline Robinet, Lucile Mollet, Patrick Gonzalez, Thierry Normand, Stephane Charpentier, et al.. The mitogaligin protein is addressed to the nucleus via a non-classical localization signal. Biochemical and Biophysical Research Communications, Elsevier, 2010, 392 (1), pp.53-57. 〈10.1016/j.bbrc.2009.12.162〉. 〈hal-00529397〉
  • 2009

  • Alexis D. Sennepin, Stéphane Charpentier, Thierry Normand, Cedric Sarre, Alain Legrand, et al.. Multiple reprobing of Western blots after inactivation of peroxidase activity by its substrate, hydrogen peroxide. Analytical Biochemistry, Elsevier Masson, 2009, 393 (1), pp.129-131. ⟨10.1016/j.ab.2009.06.004⟩. ⟨hal-00525339⟩
  • Patrick Gonzalez, Pauline Robinet, Stéphane Charpentier, Lucile Mollet, Thierry Normand, et al.. Apoptotic activity of a nuclear form of mitogaligin, a cell death protein. Biochemical and Biophysical Research Communications, Elsevier, 2009, 378 (4), pp.816-820. 〈10.1016/j.bbrc.2008.11.133〉. 〈hal-00522444〉
  • 2007

  • Patrick Gonzalez, Mélanie Duneau, Stéphane Charpentier, Thierry Normand, Lucile Mollet, et al.. Destabilization of Membranes Containing Cardiolipin or Its Precursors by Peptides Derived from Mitogaligin, a Cell Death Protein. Biochemistry, American Chemical Society, 2007, 46 (25), pp.7374-7382. ⟨10.1021/bi700213p⟩. ⟨hal-00159568⟩