LEGRAND Alain

 

mail : alain.legrand[remplacer_par_at]cnrs-orleans.fr

Phone : +33 2.38.25.55.36

Professor emeritus within the team ““DAIH: Dysregulation of Autophagy in Inflammation Due to HIV”

 


46 documents

Article dans une revue40 documents

  • Saïd El Haddad, Amandine Serrano, Fréderic Moal, Thierry Normand, Chloé Robin, et al.. Disturbed expression of autophagy genes in blood of Parkinson’s disease patients. Gene, 2020, 738, pp.144454. ⟨10.1016/j.gene.2020.144454⟩. ⟨hal-02501027⟩
  • B. Chauveau, C. Auclair, A. Legrand, R. Mangione, Laurent Gerbaud, et al.. Reply. Ultrasound in Obstetrics and Gynecology = Ultrasound in Obstetrics & Gynecology, 2019, 53 (2), pp.276-277. ⟨10.1002/uog.20164⟩. ⟨hal-03049060⟩
  • Amandine Serrano, Saïd El Haddad, Fréderic Moal, Thierry Prazuck, Eric Legac, et al.. Dysregulation of apoptosis and autophagy gene expression in peripheral blood mononuclear cells of efficiently treated HIV-infected patients. AIDS. Official journal of the international AIDS Society, 2018, 32 (12), pp.1579 - 1587. ⟨10.1097/QAD.0000000000001851⟩. ⟨hal-01936094⟩
  • Saïd El Haddad, Amandine Serrano, Thierry Normand, Chloé Robin, Martine Dubois, et al.. Interaction of Alpha-synuclein with Cytogaligin, a protein encoded by the proapoptotic gene GALIG. Biochemical and Biophysical Research Communications, 2018, 495 (1), pp.787-792. ⟨10.1016/j.bbrc.2017.11.078⟩. ⟨hal-01966108⟩
  • Kévin Moreau, Justine Surand, Aurélia Le Dantec, Christine Mosrin-Huaman, Alain Legrand, et al.. Recombinant yeast and human cells as screening tools to search for antibacterial agents targeting the transcription termination factor Rho. Journal of Antibiotics, 2018, 71 (4), pp.447-455. ⟨hal-01966171⟩
  • Lucile Mollet, Pauline Robinet, Martine Dubois, Axel Aurouet, Thierry Normand, et al.. Opposing Mcl-1, the GALIG proapoptotic gene is upregulated as neutrophils die and underexpressed in Acute Myeloid Leukemia cells.. Molecular Immunology, 2013, 56 (1-2), pp.123-8. ⟨10.1016/j.molimm.2013.04.012⟩. ⟨hal-00840170⟩
  • Violette Senille, Dominique Lelievre, Françoise Paquet, Norbert Garnier, Ned Lamb, et al.. The addressing fragment of mitogaligin: first insights into functional and structural properties.. ChemBioChem, 2013, 14 (6), pp.711-20. ⟨10.1002/cbic.201200715⟩. ⟨hal-00817503⟩
  • Pauline Robinet, Lucile Mollet, Patrick Gonzalez, Thierry Normand, Stephane Charpentier, et al.. The mitogaligin protein is addressed to the nucleus via a non-classical localization signal. Biochemical and Biophysical Research Communications, 2010, 392 (1), pp.53-57. ⟨10.1016/j.bbrc.2009.12.162⟩. ⟨hal-00529397⟩
  • Patrick Gonzalez, Pauline Robinet, Stéphane Charpentier, Lucile Mollet, Thierry Normand, et al.. Apoptotic activity of a nuclear form of mitogaligin, a cell death protein. Biochemical and Biophysical Research Communications, 2009, 378 (4), pp.816-820. ⟨10.1016/j.bbrc.2008.11.133⟩. ⟨hal-00522444⟩
  • Alexis D. Sennepin, Stéphane Charpentier, Thierry Normand, Cedric Sarre, Alain Legrand, et al.. Multiple reprobing of Western blots after inactivation of peroxidase activity by its substrate, hydrogen peroxide. Analytical Biochemistry, 2009, 393 (1), pp.129-131. ⟨10.1016/j.ab.2009.06.004⟩. ⟨hal-00525339⟩
  • Valerie Boutin, Alain Legrand, Roger Mayer, Maurice Nachtigal, Michel Monsigny, et al.. Glycofection: The Ubiquitous Roles of Sugar Bound on Glycoplexes. Drug Delivery, 2008, 6 (1), pp.45-50. ⟨10.1080/107175499267156⟩. ⟨hal-02138035⟩
  • Patrick Gonzalez, Mélanie Duneau, Stéphane Charpentier, Thierry Normand, Lucile Mollet, et al.. Destabilization of Membranes Containing Cardiolipin or Its Precursors by Peptides Derived from Mitogaligin, a Cell Death Protein. Biochemistry, 2007, 46 (25), pp.7374-7382. ⟨10.1021/bi700213p⟩. ⟨hal-00159568⟩
  • Anne Neudörffer, Jean-Pierre Desvergne, Dominique Bonnefont-Rousselot, Alain Legrand, Maurice-Bernard Fleury, et al.. Protective Effects of 4-Hydroxycinnamic Ethyl Ester Derivatives and Related Dehydrodimers against Oxidation of LDL: Radical Scavengers or Metal Chelators?. Journal of Agricultural and Food Chemistry, 2006, 54 (5), pp.1898-1905. ⟨10.1021/jf052923p⟩. ⟨hal-02384987⟩
  • M. Duneau, M. Boyer Guittaut, P. Gonzalez, S. Charpentier, T. Normand, et al.. Galig, a novel cell death gene that encodes a mitochondrial protein promoting cytochrome c release. Experimental Cell Research, 2005, 302, pp.194-205. ⟨hal-00088588⟩
  • Michaël Guittaut, Stéphane Charpentier, Thierry Normand, Martine Dubois, Jacques Raimond, et al.. Identification of an Internal Gene to the Human Galectin-3 Gene with Two Different Overlapping Reading Frames That Do Not Encode Galectin-3. Journal of Biological Chemistry, 2001, 276 (4), pp.2652-2657. ⟨10.1074/jbc.m002523200⟩. ⟨hal-02137994⟩
  • S. Fogel, M. Guittaut, Alain Legrand, M. Monsigny, E. Hebert. The Tat protein of HIV-1 induces galectin-3 expression. Glycobiology, 1999, 9 (4), pp.383-387. ⟨10.1093/glycob/9.4.383⟩. ⟨hal-02138044⟩
  • V. Carrière, V. Piller, Alain Legrand, M. Monsigny, A.C. Roche. The sugar binding activity of MR60, a mannose-specific shuttling lectin, requires a dimeric state. Glycobiology, 1999, 9 (10), pp.995-1002. ⟨10.1093/glycob/9.10.995⟩. ⟨hal-02138032⟩
  • C Arar, J.C Gaudin, L Capron, Alain Legrand. Galectin-3 gene (LGALS3) expression in experimental atherosclerosis and cultured smooth muscle cells.. FEBS Letters, 1998, 430 (3), pp.307-311. ⟨10.1016/S0014-5793(98)00683-8⟩. ⟨hal-02138144⟩
  • Alain Legrand, Drazen B. Jimonjic, Nicolae C. Popescu, Maurice Nachtigal. A Chromosome 4 Satellite I DNA Isolated from SV40-Transformed Human Cells. DNA Research, 1998, 5 (5), pp.271-276. ⟨10.1093/dnares/5.5.271⟩. ⟨hal-02138074⟩
  • J. Raimond, D Zimonjic, C. Mignon, M. Mattei, N Popescu, et al.. Mapping of the galectin-3 gene (LGALS3) to human chromosome 14 at region 14q21-22.. Mammalian Genome, 1997, 8 (9), pp.706-707. ⟨hal-02138375⟩
  • Jean-Charles Gaudin, Chantal Arar, Michel Monsigny, Alain Legrand. Modulation of the expression of the rabbit galectin-3 gene by p53 and c-Ha-ras proteins and PMA. Glycobiology, 1997, 7 (8), pp.1089-1098. ⟨10.1093/glycob/7.8.1089⟩. ⟨hal-02138352⟩
  • Alain Legrand, E.P Mayer, S Dalvi, M Nachtigal. Transformation of rabbit vascular smooth muscle cells by human cytomegalovirus morphological transforming region I.. American Journal of Pathology, 1997, 151 (5), pp.1387-95. ⟨hal-02138369⟩
  • C Arar, C. Mignon, M. Mattei, M. Monsigny, Alexis Roche, et al.. Mapping of the MR60/ERGIC-53 gene to human chromosome 18q21.3-18q22 by in situ hybridization.. Mammalian Genome, 1996, 7 (10), pp.791-2. ⟨10.1007/s003359900238⟩. ⟨hal-02138384⟩
  • V Vergé, Alain Legrand, T Hévor. Isolation of carbohydrate metabolic clones from cultured astrocytes. Glia, 1996, 18 (3), pp.244-254. 3.0.CO;2-Z">⟨10.1002/(SICI)1098-1136(199611)18:3<244::AID-GLIA8>3.0.CO;2-Z⟩. ⟨hal-02138380⟩
  • J Raimond, F Rouleux, M. Monsigny, Alain Legrand. The second intron of the human galectin-3 gene has a strong promoter activity down-regulated by p53.. FEBS Letters, 1995, 363 (1-2), pp.165-9. ⟨10.1016/0014-5793(95)00310-6⟩. ⟨hal-02138402⟩
  • J-C Gaudin, M. Monsigny, Alain Legrand. Cloning of the cDNA encoding rabbit galectin-3.. Gene, 1995, 163 (2), pp.249-52. ⟨10.1016/0378-1119(95)00388-M⟩. ⟨hal-02138396⟩
  • Chantal Arar, Valérie Carpentier, Jean-Pierre Le Caer, Michel Monsigny, Alain Legrand, et al.. ERGIC-53, a Membrane Protein of the Endoplasmic Reticulum-Golgi Intermediate Compartment, Is Identical to MR60, an Intracellular Mannose-specific Lectin of Myelomonocytic Cells. Journal of Biological Chemistry, 1995, 270 (8), pp.3551-3553. ⟨10.1074/jbc.270.8.3551⟩. ⟨hal-02138409⟩
  • F Rouleux-Bonnin, M. Monsigny, Alain Legrand. Transcriptional expression of mannose receptor gene during differentiation of human macrophages.. Biochemical and Biophysical Research Communications, 1995, 217 (1), pp.106-12. ⟨hal-02138393⟩
  • J. Raimond, C. Plessis, F. Fargette, Alain Legrand, E. Hebert. An EBV-Based Vector Allowing a High Level of LTRHIV-Directed Expression in Human Cells. Plasmid, 1994, 32 (1), pp.70-74. ⟨10.1006/plas.1994.1045⟩. ⟨hal-02138444⟩
  • Florence Rouleux, Michel Monsigny, Alain Legrand. A Negative Regulatory Element of the Macrophage-Specific Human Mannose Receptor Gene Represses Its Expression in Nonmyeloid Cells. Experimental Cell Research, 1994, 214 (1), pp.113-119. ⟨10.1006/excr.1994.1239⟩. ⟨hal-02138011⟩
  • N Bizouarne, V. Denis, Alain Legrand, M. Monsigny, C. Kieda. A SV-40 immortalized murine endothelial cell line from peripheral lymph node high endothelium expresses a new alpha-L-fucose binding protein.. Biology of the Cell, 1993, 79 (3), pp.209-18. ⟨10.1016/0248-4900(93)90139-6⟩. ⟨hal-02138452⟩
  • Patrick Midoux, Christina Mendes, Alain Legrand, Jacques Raimond, Roger Mayer, et al.. Specific gene transfer mediated by lactosylated poly-L-lysine into hepatoma cells. Nucleic Acids Research, 1993, 21 (4), pp.871-878. ⟨10.1093/nar/21.4.871⟩. ⟨hal-02138456⟩
  • Alain Legrand, P Greenspan, M Nagpal, S Nachtigal, M Nachtigal. Characterization of human vascular smooth muscle cells transformed by the early genetic region of SV40 virus.. American Journal of Pathology, 1991, 139 (3), pp.629-640. ⟨hal-02138458⟩
  • Alain Legrand, Maurice Nachtigal. Homologous Recombination of a Plasmid Containing the SV40 Early Region in Rabbit Cells. Intervirology, 1991, 32 (3), pp.173-184. ⟨10.1159/000150197⟩. ⟨hal-02138462⟩
  • M Nachtigal, Alain Legrand, M Nagpal, S Nachtigal, P Greenspan. Transformation of rabbit vascular smooth muscle cells by transfection with the early region of SV40 DNA.. American Journal of Pathology, 1990, 136 (2), pp.297-306. ⟨hal-02138474⟩
  • M. Nachtigal, Alain Legrand, P. Greenspan, S Nachtigal, M. Nagpal. Immortalization of Rabbit Vascular Smooth Muscle Cells after Transfection with a Fragment of the BglII N Region of Herpes Simplex Virus Type 2 DNA. Intervirology, 1990, 31 (2-4), pp.166-174. ⟨10.1159/000150151⟩. ⟨hal-02138469⟩
  • M Nachtigal, M Nagpal, P Greenspan, A Nachtigal, Alain Legrand. Characterization of a continuous smooth muscle cell line derived from rabbit aorta.. In vitro cellular & developmental biology : journal of the Tissue Culture Association, 1989, 25 (10), pp.892-8. ⟨10.1007/BF02624001⟩. ⟨hal-02138476⟩
  • C. Nicolau, Alain Legrand, E. Grosse. Liposomes as carriers for in vivo gene transfer and expression.. Methods in Enzymology, 1987, 149, pp.157-76. ⟨10.1016/0076-6879(87)49054-X⟩. ⟨hal-02138481⟩
  • P Nandi, Alain Legrand, C. Nicolau. Biologically active, recombinant DNA in clathrin-coated vesicles isolated from rat livers after in vivo injection of liposome-encapsulated DNA.. Journal of Biological Chemistry, 1986, 261 (35), pp.16722-6. ⟨hal-02138484⟩
  • P. Soriano, J Dijkstra, Alain Legrand, H. Spanjer, D. Londos-Gagliardi, et al.. Targeted and nontargeted liposomes for in vivo transfer to rat liver cells of a plasmid containing the preproinsulin I gene.. Proceedings of the National Academy of Sciences of the United States of America, 1983, 80 (23), pp.7128-7131. ⟨10.1073/pnas.80.23.7128⟩. ⟨hal-02138490⟩

Communication dans un congrès6 documents

  • S. El Haddad, A. Serrano, Thierry Normand, Fabienne Brulé-Morabito, L. Mollet, et al.. Cytogaligin, an additional link between Parkinson’s disease and autophagy pathways?. 7e Congrès du CFATG, Nov 2017, Paris, France. ⟨hal-02934905⟩
  • A. Serrano, Thierry Normand, S. El Haddad, M. Dubois, Stéphane Charpentier, et al.. During efficient Anti-RetroViral (ARV) therapy, the expression of GALIG and its interacting partners involved in macroautophagy are deregulated. 6es Journées Scientifiques du CFATG, Oct 2016, Bordeaux, France. ⟨hal-02934903⟩
  • S El Haddad, C Ozsancak, A Serrano, M Dubois, P. Auzou, et al.. Etude de l’expression génique dans la maladie de Parkinson. Journées de Neurologie de Langue Française, Apr 2016, Nantes, France. ⟨hal-03661927⟩
  • S El Haddad, A Serrano, C Ozsancak, P. Auzou, F Moal, et al.. Genes de l’autophagie : marqueurs sanguins potentiels de la maladie de Parkinson. Journées de Neurologie de Langue Française, Apr 2016, Nantes, France. ⟨hal-03661930⟩
  • A Serrano, T Guery, S El Haddad, M Dubois, M Schoenwald, et al.. GALIG, gène inducteur de la mort cellulaire, s’exprime au cours de la différenciation myéloïde. 10es Journées du Cancéropole Grand Ouest, Jun 2016, Les Sables d'Olonne, France. ⟨hal-03661932⟩
  • A Serrano, S El Haddad, T Normand, M Dubois, T Guery, et al.. Cytogaligin, one of the proteins produced by the proapoptotic GALIG gene, interacts with autophagy and proteasome molecules. 7th Proteasome Autophagy Workshop, Apr 2016, Clermont-Ferrand, France. ⟨hal-03661923⟩

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