MOSRIN-HUAMAN Christine

email : christine.mosrin[remplacer_par_at]cnrs-orleans.fr

Phone : +33 2.38.25.76.11

Researcher within the thematic group “Pharmacological targets and biomarkers

 



21 documents

Article dans une revue

  • Kévin Moreau, Aurélia Le Dantec, Christine Mosrin-Huaman, Yves Bigot, Benoit Piegu, et al.. Perturbation of mRNP biogenesis reveals a dynamic landscape of the Rrp6-dependent surveillance machinery trafficking along the yeast genome. RNA Biology, Taylor & Francis, 2019, pp.1-11. ⟨10.1080/15476286.2019.1593745⟩. ⟨hal-02117640⟩
  • Kévin Moreau, Justine Surand, Aurélia Le Dantec, Christine Mosrin-Huaman, Alain Legrand, et al.. Recombinant yeast and human cells as screening tools to search for antibacterial agents targeting the transcription termination factor Rho. Journal of Antibiotics, Nature Publishing Group: Open Access Hybrid Model Option B, 2018, 71 (4), pp.447-455. ⟨hal-01966171⟩
  • Christine Mosrin-Huaman, Nadège Hervouet-Coste, A. Rachid Rahmouni. Co-transcriptional degradation by the 5′-3′ exonuclease Rat1p mediates quality control of HXK1 mRNP biogenesis in S. cerevisiae. RNA Biology, Taylor & Francis, 2016, 13 (6), pp.582 - 592. ⟨10.1080/15476286.2016.1181255⟩. ⟨hal-01407513⟩
  • Rachid A. Rahmouni, Christine Mosrin-Huaman. In Situ Footprinting of E. coli Transcription Elongation Complex with Chloroacetaldehyde. Methods in Molecular Biology, Humana Press/Springer Imprint, 2015, Methods in Molecular Biology, 1276, pp.229-240. ⟨10.1007/978-1-4939-2392-2_13⟩. ⟨hal-01171857⟩
  • Christine Mosrin-Huaman, Nadege Hervouet-Coste, Aurélia Le Dantec, Igor Stuparevic, A. Rachid Rahmouni. Bacterial Rho helicase: a new tool to dissect mRNP biogenesis and quality control in yeast. Trends in cell and molecular biology, Research Trends, 2014, 9, pp.79 - 93. ⟨hal-01179495⟩
  • Igor Stuparevic, Christine Mosrin-Huaman, Nadège Hervouet-Coste, Mateja Remenaric, A. Rachid Rahmouni. Co-transcriptional recruitment of the RNA exosome cofactors Rrp47p, Mpp6p and two distinct TRAMP complexes assists the exonuclease Rrp6p in the targeting and degradation of an aberrant mRNP in yeast. Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 2013, ⟨10.1074/jbc.M113.491290⟩. ⟨hal-00874892⟩
  • Romy Honorine, Christine Mosrin-Huaman, Nadege Hervouet-Coste, Domenico Libri, Rachid A. Rahmouni. Nuclear mRNA quality control in yeast is mediated by Nrd1 co-transcriptional recruitment, as revealed by the targeting of Rho-induced aberrant transcripts. Nucleic Acids Research, Oxford University Press, 2011, 39 (7), pp.2809-2820. ⟨10.1093/nar/gkq1192⟩. ⟨hal-00602376⟩
  • Christine Mosrin-Huaman, Romy Honorine, A. Rachid Rahmouni. Expression of Bacterial Rho Factor in Yeast Identifies New Factors Involved in the Functional Interplay between Transcription and mRNP Biogenesis. Molecular and Cellular Biology, American Society for Microbiology, 2009, 29 (15), pp.4033-4044. ⟨10.1128/MCB.00272-09⟩. ⟨hal-00525149⟩
  • F. ToulmÉ, C. Mosrin-Huaman, I. Artsimovitch, A.R. Rahmouni. Transcriptional pausing in vivo: a nascent RNA hairpin restricts lateral movements of RNA polymerase in both forward and reverse directions. Journal of Molecular Biology, Elsevier, 2005, 351, pp.39-51. ⟨hal-00088714⟩
  • C. Mosrin-Huaman, C.L. Turnbough, A.R. Rahmouni. Translocation of Escherichia coli RNA polymerase against a protein roadblock in vivo highlights a passive sliding mechanism for transcript elongation. Molecular Microbiology, Wiley, 2004, 51, pp.1471-1481. ⟨hal-00113075⟩
  • F Toulmé, M Mosrin-Huaman, J Sparkowski, A. Das, M. Leng, et al.. GreA and GreB proteins revive backtracked RNA polymerase in vivo by promoting transcript trimming. EMBO Journal, EMBO Press, 2000, 19 (24), pp.6853-6859. ⟨10.1093/emboj/19.24.6853⟩. ⟨hal-02127250⟩
  • M. Decoville, M Giraud-Panis, M Mosrin-Huaman, M. Leng, D. Locker. HMG boxes of DSP1 protein interact with the Rel homology domain of transcription factors. Nucleic Acids Research, Oxford University Press, 2000, 28 (2), pp.454-462. ⟨10.1093/nar/28.2.454⟩. ⟨hal-02119310⟩
  • M Mosrin-Huaman, L. Canaple, D. Locker, M. Decoville. DSP1Gene ofDrosophila melanogaster encodes an HMG-domain protein that plays multiple roles in development. Developmental Genetics, John Wiley & Sons, 1998, 23 (4), pp.324-334. 3.0.CO;2-T">⟨10.1002/(SICI)1520-6408(1998)23:4<324::AID-DVG7>3.0.CO;2-T⟩. ⟨hal-02119315⟩
  • Christine Mosrin-Huaman, M. Riva, M Beltrame, E Cassar, A. Sentenac, et al.. The RPC31 gene of Saccharomyces cerevisiae encodes a subunit of RNA polymerase C (III) with an acidic tail.. Molecular and Cellular Biology, American Society for Microbiology, 1990, 10 (9), pp.4737-4743. ⟨10.1128/mcb.10.9.4737⟩. ⟨hal-02266468⟩
  • Sabine Kreps, Fabrice Ferino, Christine Mosrin-Huaman, Jozef Gerits, Max Mergeay, et al.. Conjugative transfer and autonomous replication of a promiscuous IncQ plasmid in the cyanobacterium Synechocystis PCC 6803. Molecular and General Genetics MGG, Springer Verlag, 1990, 221 (1), pp.129-133. ⟨10.1007/BF00280378⟩. ⟨hal-02266473⟩
  • Christine Mosrin-Huaman, P Thuriaux. The genetics of RNA polymerases in yeasts.. Current Genetics, Springer Verlag, 1990, 17 (5), pp.367-373. ⟨hal-02266470⟩

Poster

  • Kévin Moreau, Aurélia Le Dantec, Christine Mosrin-Huaman, Benoit Piégu, Yves Bigot, et al.. Analyse métagénomique du mécanisme de discrimination entre les transcrits codants et non-codants par la machinerie de dégradation de l’ARN. 29e colloque Biotechnocentre, Oct 2016, Seillac, France. ⟨hal-02453482⟩
  • A. Rachid Rahmouni, Christine Mosrin-Huaman, Nadege Hervouet-Coste. Co-transcriptional degradation by the 5’-3’ exonuclease Rat1p mediates quality control of HXK1 mRNP biogenesis in S. cerevisiae. EMBO EMBL Symposium: The Complex Life of mRNA, Oct 2016, Heidelberg, Germany. ⟨hal-02453485⟩

Chapitre d'ouvrage

  • P. Thuriaux, Christine Mosrin-Huaman. La génétique moléculaire des levures. Biotechnologie des levures, elsevier masson, pp.49-80, 1991. ⟨hal-02181574⟩
  • D. Gallwitz, J. Becker, M. Benli, L. Hengst, C. Mosrin-Huaman, et al.. The YPT-Branch of the ras Superfamily of GTP-Binding Proteins in Yeast: Functional Importance of the Putative Effector Region. The Superfamily of ras-Related Genes, Springer US, pp.121-128, 1991, 978-1-4684-6020-9. ⟨hal-02181563⟩
  • Christine Mosrin-Huaman, P. Thuriaux. Les outils du génie génétique. Biotechnologies des levures, Masson, pp.81-96, 1991. ⟨hal-02266466⟩

 

VALLÉE-MEHEUST Béatrice

 

email : beatrice.vallee[remplacer_par]cnrs-orleans.fr

Phone : +33 2.38.25.76.11

Researcher within the thematic group “Pharmacological targets and biomarkers

 



28 documents

Article dans une revue

  • B. VallÉe, A. Liarsou, L. Dagot. La déférence : une norme sociale complémentaire de l’internalité en contexte de promotion professionnelle ?. Psychologie du travail et des organisations, Elsevier Masson, 2020, ⟨10.1016/j.pto.2020.01.001⟩. ⟨hal-02491044⟩
  • Julie Tastet, Hélène Cuberos, Béatrice Vallée, Annick Toutain, Martine Raynaud, et al.. LIMK2-1 is a Hominidae-Specific Isoform of LIMK2 Expressed in Central Nervous System and Associated with Intellectual Disability. Neuroscience, Elsevier - International Brain Research Organization, 2019, 399, pp.199-210. ⟨10.1016/j.neuroscience.2018.12.017⟩. ⟨hal-02067472⟩
  • Béatrice Vallée, Michel Doudeau, Fabienne Godin, Hélène Bénédetti. Characterization at the Molecular Level using Robust Biochemical Approaches of a New Kinase Protein. Journal of visualized experiments : JoVE, JoVE, 2019, pp.e59820. ⟨10.3791/59820⟩. ⟨hal-02282630⟩
  • A. de Cola, M. Franceschini, A. Di Matteo, G. Colotti, R. Celani, et al.. N6L pseudopeptide interferes with nucleophosmin protein-protein interactions and sensitizes leukemic cells to chemotherapy. Cancer Letters, Elsevier, 2018, 412, pp.272-282. ⟨10.1016/j.canlet.2017.10.038⟩. ⟨hal-02350445⟩
  • Béatrice Vallée, Hélène Cuberos, Michel Doudeau, Fabienne Godin, David Gosset, et al.. LIMK2-1, a new isoform of human LIMK2, regulates actin cytoskeleton remodeling via a different signaling pathway than that of its two homologs, LIMK2a and LIMK2b. Biochemical Journal, Portland Press, 2018, 475 (23), pp.3745-3761. ⟨hal-01966439⟩
  • B. VallÉe, L. Larrède, V. Willaume, A. Pascual, S. Meineri. Effets à long terme d’une stratégie engageante : augmenter le nombre d’adhésions de l’association sportive d’un collège mahorais. Pratiques Psychologiques, Elsevier Masson, 2016, 22 (4), pp.353-362. ⟨10.1016/j.prps.2016.07.002⟩. ⟨hal-02493232⟩
  • H. Cuberos, B. VallÉe, P. Vourc'H, J. Tastet, C.R. Andres, et al.. Roles of LIM kinases in central nervous system function and dysfunction. FEBS Letters, Wiley, 2015, 589 (24PartB), pp.3795-3806. ⟨10.1016/j.febslet.2015.10.032⟩. ⟨hal-02072231⟩
  • Martine Beaufour, Fabienne Godin, Béatrice Vallée, Martine Cadene, Hélène Bénédetti. Interaction Proteomics Suggests a New Role for the Tfs1 Protein in Yeast.. Journal of Proteome Research, American Chemical Society, 2012, 11 (6), pp.3211-3218. ⟨10.1021/pr201239t⟩. ⟨hal-00721771⟩
  • Julie Tastet, Patrick Vourc'H, Frédéric Laumonnier, Béatrice Vallée, Carole Michelle, et al.. LIMK2d, a truncated isoform of Lim kinase 2 regulates neurite growth in absence of the LIM kinase domain. Biochemical and Biophysical Research Communications, Elsevier, 2012, 420 (2), pp.247-252. ⟨10.1016/j.bbrc.2012.02.134⟩. ⟨hal-01136281⟩
  • Fabienne Godin, Sandrine Villette, Béatrice Vallée, Michel Doudeau, Séverine Morisset-Lopez, et al.. A fraction of neurofibromin interacts with PML bodies in the nucleus of the CCF astrocytoma cell line.. Biochemical and Biophysical Research Communications, Elsevier, 2012, 418 (4), pp.689-94. ⟨10.1016/j.bbrc.2012.01.079⟩. ⟨hal-00721861⟩
  • Béatrice Vallée, Michel Doudeau, Fabienne Godin, Aurélie Gombault, Aurélie Tchalikian, et al.. Nf1 RasGAP inhibition of LIMK2 mediates a new cross-talk between Ras and Rho pathways.. PLoS ONE, Public Library of Science, 2012, 7 (10), pp.e47283. ⟨10.1371/journal.pone.0047283⟩. ⟨hal-00817355⟩
  • Aurélie Gombault, Jonas Warringer, Robert Caesar, Fabienne Godin, Béatrice Vallée, et al.. A phenotypic study of TFS1 mutants differentially altered in the inhibition of Ira2p or CPY. FEMS Yeast Research, Oxford University Press (OUP), 2009, 9 (6), pp.867-874. ⟨10.1111/j.1567-1364.2009.00535.x⟩. ⟨hal-00522432⟩
  • A. Pascual, L. Dagot, B. VallÉe, N. Gueguen. Soumission sans pression, médiatisation d’un tsunami et don d’argent : efficacité comparée de la porte-au-nez et du « vous êtes libre de… ». European Review of Applied Psychology / Revue Européenne de Psychologie Appliquée, Elsevier, 2009, 59 (1), pp.79-84. ⟨10.1016/j.erap.2006.07.003⟩. ⟨hal-02493142⟩
  • Aurélie Gombault, Fabienne Godin, Denise Sy, Baptiste Legrand, Hélène Chautard, et al.. Molecular Basis of the Tfs1/Ira2 Interaction: A Combined Protein Engineering and Molecular Modelling Study. Journal of Molecular Biology, Elsevier, 2007, 374 (3), pp.604-617. ⟨10.1016/j.jmb.2007.09.057⟩. ⟨hal-00181161⟩
  • Béatrice Vallée, H. Riezman. Lip 1p: a novel subunit of acyl-CoA ceramide synthase. EMBO Journal, EMBO Press, 2005, 24, pp.730-741. ⟨hal-00088715⟩
  • Béatrice Vallée, G Coadou, H. Labbé, D. Sy, F. Vovelle, et al.. Peptides corresponding to the N- and C-terminal parts of PEBP are well-structured in solution: new insights into their possible interaction with partners in vivo.. Journal of Peptide Research, Wiley-Blackwell, 2003, 61 (2), pp.47-57. ⟨hal-02118669⟩
  • Kouichi Funato, Ruben Lombardi, Béatrice Vallée, Howard Riezman. Lcb4p Is a Key Regulator of Ceramide Synthesis from Exogenous Long Chain Sphingoid Base in Saccharomyces cerevisiae. Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 2003, 278 (9), pp.7325-7334. ⟨10.1074/jbc.M209925200⟩. ⟨hal-02118660⟩
  • Kouichi Funato, Béatrice Vallée, Howard Riezman. Biosynthesis and Trafficking of Sphingolipids in the Yeast Saccharomyces cerevisiae †. Biochemistry, American Chemical Society, 2002, 41 (51), pp.15105-15114. ⟨10.1021/bi026616d⟩. ⟨hal-02118664⟩
  • D Schorling, Béatrice Vallée, Wolfgang Barz, Howard Riezman, Dieter Oesterhelt. Lag1p and Lac1p Are Essential for the Acyl-CoA–dependent Ceramide Synthase Reaction in Saccharomyces cerevisae. Molecular Biology of the Cell, American Society for Cell Biology, 2001, 12 (11), pp.3417-3427. ⟨10.1091/mbc.12.11.3417⟩. ⟨hal-02118674⟩
  • Béatrice Vallée, P Tauc, J Brochon, M Maget-Dana, D. Lelièvre, et al.. Behaviour of bovine phosphatidylethanolamine-binding protein with model membranes. Evidence of affinity for negatively charged membranes.. European Journal of Biochemistry, Wiley, 2001, 268 (22), pp.5831-41. ⟨hal-02118681⟩
  • Béatrice Vallée, C. Teyssier, R. Maget-Dana, J. Ramstein, N. Bureaud, et al.. Stability and physicochemical properties of the bovine brain phosphatidylethanolamine-binding protein.. European Journal of Biochemistry, Wiley, 1999, 266 (1), pp.40-52. ⟨hal-02118686⟩
  • C. Serre, Béatrice Vallée, N. Bureaud, F. Schoentgen, C. Zelwer. Crystal structure of the phosphatidylethanolamine-binding protein from bovine brain: a novel structural class of phospholipid-binding proteins.. Structure, Elsevier (Cell Press), 1998, 6 (10), pp.1255-65. ⟨hal-02118689⟩

Poster

  • A. Champiré, A. Braka, Béatrice Vallée, M. Doudeau, F. Godin, et al.. Design, synthesis and biological evaluation of LIMK inhibitors. XXIVe Journées Jeunes Chercheurs (SCT), Feb 2017, Châtenay-Malabry, France. ⟨hal-02904837⟩
  • Béatrice Vallée, Michel Doudeau, Fabienne Godin, Anthony Champiré, Karen Plé, et al.. LIM kinases: new therapeutic targets to treat Neurofibromatosis type I. The 7th EMBO meeting, Sep 2016, Mannheim, Germany. ⟨hal-02453490⟩
  • Hélène Bénédetti, Fabienne Godin, Michel Doudeau, Béatrice Vallée, Marie-Ludivine De Tauzia, et al.. LINGO-1, a protein involved in various neurodevelopmental processes, interacts with neurofibromin (Nf1), the protein responsible for neurofibromatosis type I: molecular studies and functional implications. 10 th FENS (Forum of Neuroscience), Jul 2016, Copenhague, Denmark. ⟨hal-02453487⟩
  • Béatrice Vallée, Hélène Cuberos, Michel Doudeau, Fabienne Godin, Patrick Vourc’h, et al.. The three isoforms of human LIMK2 regulate actin cytoskeleton remodeling via different pathways. EMBL Symposium, Actin in action: From Molecules to Cellular Functions, Sep 2016, Heidelberg, Germany. ⟨hal-02453489⟩
  • Béatrice Vallée, Hélène Cuberos, Julie Tastet, Michel Doudeau, Fabienne Godin, et al.. LIMK2-1, a new primate-specific isoform of LIMK2, is associated with intellectual disability. 10 th FENS (Forum of Neurosciences), Jul 2016, Copenhague, Denmark. ⟨hal-02453486⟩
  • A. Champiré, A. Braka, Béatrice Vallée, M. Doudeau, F. Godin, et al.. Conception, synthèse et évaluation biologique d’inhibiteurs de LIM kinases. 29e colloque de Biotechnocentre, Oct 2016, Seillac, France. ⟨hal-02904847⟩

GODIN Fabienne

email : fabienne.godin[remplacer_par_at]cnrs-orleans.fr

Phone : +33 2.38.25.76.05

Engineer in biological techniques within the thematic group Cell signalling and neurofibromatosis

 



16 documents

Article dans une revue

  • Béatrice Vallée, Michel Doudeau, Fabienne Godin, Hélène Bénédetti. Characterization at the Molecular Level using Robust Biochemical Approaches of a New Kinase Protein. Journal of visualized experiments : JoVE, JoVE, 2019, pp.e59820. ⟨10.3791/59820⟩. ⟨hal-02282630⟩
  • Béatrice Vallée, Hélène Cuberos, Michel Doudeau, Fabienne Godin, David Gosset, et al.. LIMK2-1, a new isoform of human LIMK2, regulates actin cytoskeleton remodeling via a different signaling pathway than that of its two homologs, LIMK2a and LIMK2b. Biochemical Journal, Portland Press, 2018, 475 (23), pp.3745-3761. ⟨hal-01966439⟩
  • L Cobret, M L de Tauzia, J Ferent, E Traiffort, I Hénaoui, et al.. Targeting the cis-dimerization of LINGO-1 with low MW compounds affects its downstream signalling. British Journal of Clinical Pharmacology, Wiley, 2015, 172 (3), pp.841-856. ⟨10.1111/bph.12945⟩. ⟨hal-01170735⟩
  • Martine Beaufour, Fabienne Godin, Béatrice Vallée, Martine Cadene, Hélène Bénédetti. Interaction Proteomics Suggests a New Role for the Tfs1 Protein in Yeast.. Journal of Proteome Research, American Chemical Society, 2012, 11 (6), pp.3211-3218. ⟨10.1021/pr201239t⟩. ⟨hal-00721771⟩
  • Fabienne Godin, Sandrine Villette, Béatrice Vallée, Michel Doudeau, Séverine Morisset-Lopez, et al.. A fraction of neurofibromin interacts with PML bodies in the nucleus of the CCF astrocytoma cell line.. Biochemical and Biophysical Research Communications, Elsevier, 2012, 418 (4), pp.689-94. ⟨10.1016/j.bbrc.2012.01.079⟩. ⟨hal-00721861⟩
  • Béatrice Vallée, Michel Doudeau, Fabienne Godin, Aurélie Gombault, Aurélie Tchalikian, et al.. Nf1 RasGAP inhibition of LIMK2 mediates a new cross-talk between Ras and Rho pathways.. PLoS ONE, Public Library of Science, 2012, 7 (10), pp.e47283. ⟨10.1371/journal.pone.0047283⟩. ⟨hal-00817355⟩
  • Aurélie Gombault, Jonas Warringer, Robert Caesar, Fabienne Godin, Béatrice Vallée, et al.. A phenotypic study of TFS1 mutants differentially altered in the inhibition of Ira2p or CPY. FEMS Yeast Research, Oxford University Press (OUP), 2009, 9 (6), pp.867-874. ⟨10.1111/j.1567-1364.2009.00535.x⟩. ⟨hal-00522432⟩
  • Aurélie Gombault, Fabienne Godin, Denise Sy, Baptiste Legrand, Hélène Chautard, et al.. Molecular Basis of the Tfs1/Ira2 Interaction: A Combined Protein Engineering and Molecular Modelling Study. Journal of Molecular Biology, Elsevier, 2007, 374 (3), pp.604-617. ⟨10.1016/j.jmb.2007.09.057⟩. ⟨hal-00181161⟩
  • Pierre L. Roubertoux, F Sluyter, Michèle Carlier, B Marcet, F Maarouf-Veray, et al.. Mitochondrial DNA modifies cognition in interaction with the nuclear genome and age in mice. Nature Genetics, Nature Publishing Group, 2003, 35 (1), pp.65-69. ⟨10.1038/ng1230⟩. ⟨hal-01441349⟩

Poster

  • A. Champiré, A. Braka, Béatrice Vallée, M. Doudeau, F. Godin, et al.. Design, synthesis and biological evaluation of LIMK inhibitors. XXIVe Journées Jeunes Chercheurs (SCT), Feb 2017, Châtenay-Malabry, France. ⟨hal-02904837⟩
  • A. Champiré, A. Braka, B. VallÉe, M. Doudeau, F. Godin, et al.. LIM kinases as new therapeutic targets for the treatment of neurofibromatosis type 1. VII International Symposium on Advances in Synthetic and Medicinal Chemistry (EFMC) –, Aug 2017, Vienne, Austria. ⟨hal-02904794⟩
  • Béatrice Vallée, Michel Doudeau, Fabienne Godin, Anthony Champiré, Karen Plé, et al.. LIM kinases: new therapeutic targets to treat Neurofibromatosis type I. The 7th EMBO meeting, Sep 2016, Mannheim, Germany. ⟨hal-02453490⟩
  • Hélène Bénédetti, Fabienne Godin, Michel Doudeau, Béatrice Vallée, Marie-Ludivine De Tauzia, et al.. LINGO-1, a protein involved in various neurodevelopmental processes, interacts with neurofibromin (Nf1), the protein responsible for neurofibromatosis type I: molecular studies and functional implications. 10 th FENS (Forum of Neuroscience), Jul 2016, Copenhague, Denmark. ⟨hal-02453487⟩
  • Béatrice Vallée, Hélène Cuberos, Michel Doudeau, Fabienne Godin, Patrick Vourc’h, et al.. The three isoforms of human LIMK2 regulate actin cytoskeleton remodeling via different pathways. EMBL Symposium, Actin in action: From Molecules to Cellular Functions, Sep 2016, Heidelberg, Germany. ⟨hal-02453489⟩
  • Béatrice Vallée, Hélène Cuberos, Julie Tastet, Michel Doudeau, Fabienne Godin, et al.. LIMK2-1, a new primate-specific isoform of LIMK2, is associated with intellectual disability. 10 th FENS (Forum of Neurosciences), Jul 2016, Copenhague, Denmark. ⟨hal-02453486⟩
  • A. Champiré, A. Braka, Béatrice Vallée, M. Doudeau, F. Godin, et al.. Conception, synthèse et évaluation biologique d’inhibiteurs de LIM kinases. 29e colloque de Biotechnocentre, Oct 2016, Seillac, France. ⟨hal-02904847⟩

DOUDEAU Michel

email : michel.doudeau[remplacer_par_at]cnrs-orleans.fr

Phone : +33 2.38.25.76.05

Assistant engineer in Biology, Natural sciences within the thematic group “Cell signalling and neurofibromatosis”

 



13 documents

Article dans une revue

  • Béatrice Vallée, Michel Doudeau, Fabienne Godin, Hélène Bénédetti. Characterization at the Molecular Level using Robust Biochemical Approaches of a New Kinase Protein. Journal of visualized experiments : JoVE, JoVE, 2019, pp.e59820. ⟨10.3791/59820⟩. ⟨hal-02282630⟩
  • Béatrice Vallée, Hélène Cuberos, Michel Doudeau, Fabienne Godin, David Gosset, et al.. LIMK2-1, a new isoform of human LIMK2, regulates actin cytoskeleton remodeling via a different signaling pathway than that of its two homologs, LIMK2a and LIMK2b. Biochemical Journal, Portland Press, 2018, 475 (23), pp.3745-3761. ⟨hal-01966439⟩
  • Fabienne Godin, Sandrine Villette, Béatrice Vallée, Michel Doudeau, Séverine Morisset-Lopez, et al.. A fraction of neurofibromin interacts with PML bodies in the nucleus of the CCF astrocytoma cell line.. Biochemical and Biophysical Research Communications, Elsevier, 2012, 418 (4), pp.689-94. ⟨10.1016/j.bbrc.2012.01.079⟩. ⟨hal-00721861⟩
  • Béatrice Vallée, Michel Doudeau, Fabienne Godin, Aurélie Gombault, Aurélie Tchalikian, et al.. Nf1 RasGAP inhibition of LIMK2 mediates a new cross-talk between Ras and Rho pathways.. PLoS ONE, Public Library of Science, 2012, 7 (10), pp.e47283. ⟨10.1371/journal.pone.0047283⟩. ⟨hal-00817355⟩
  • Aurélie Gombault, Jonas Warringer, Robert Caesar, Fabienne Godin, Béatrice Vallée, et al.. A phenotypic study of TFS1 mutants differentially altered in the inhibition of Ira2p or CPY. FEMS Yeast Research, Oxford University Press (OUP), 2009, 9 (6), pp.867-874. ⟨10.1111/j.1567-1364.2009.00535.x⟩. ⟨hal-00522432⟩
  • Simon Amiard, Michel Doudeau, Sébastien Pinte, Anaïs Poulet, Christelle Lenain, et al.. A topological mechanism for TRF2-enhanced strand invasion. Nature Structural and Molecular Biology, Nature Publishing Group, 2007, 14 (2), pp.147-154. ⟨10.1038/nsmb1192⟩. ⟨hal-00158337⟩

Poster

  • A. Champiré, A. Braka, Béatrice Vallée, M. Doudeau, F. Godin, et al.. Design, synthesis and biological evaluation of LIMK inhibitors. XXIVe Journées Jeunes Chercheurs (SCT), Feb 2017, Châtenay-Malabry, France. ⟨hal-02904837⟩
  • A. Champiré, A. Braka, B. VallÉe, M. Doudeau, F. Godin, et al.. LIM kinases as new therapeutic targets for the treatment of neurofibromatosis type 1. VII International Symposium on Advances in Synthetic and Medicinal Chemistry (EFMC) –, Aug 2017, Vienne, Austria. ⟨hal-02904794⟩
  • Béatrice Vallée, Michel Doudeau, Fabienne Godin, Anthony Champiré, Karen Plé, et al.. LIM kinases: new therapeutic targets to treat Neurofibromatosis type I. The 7th EMBO meeting, Sep 2016, Mannheim, Germany. ⟨hal-02453490⟩
  • Hélène Bénédetti, Fabienne Godin, Michel Doudeau, Béatrice Vallée, Marie-Ludivine De Tauzia, et al.. LINGO-1, a protein involved in various neurodevelopmental processes, interacts with neurofibromin (Nf1), the protein responsible for neurofibromatosis type I: molecular studies and functional implications. 10 th FENS (Forum of Neuroscience), Jul 2016, Copenhague, Denmark. ⟨hal-02453487⟩
  • Béatrice Vallée, Hélène Cuberos, Michel Doudeau, Fabienne Godin, Patrick Vourc’h, et al.. The three isoforms of human LIMK2 regulate actin cytoskeleton remodeling via different pathways. EMBL Symposium, Actin in action: From Molecules to Cellular Functions, Sep 2016, Heidelberg, Germany. ⟨hal-02453489⟩
  • Béatrice Vallée, Hélène Cuberos, Julie Tastet, Michel Doudeau, Fabienne Godin, et al.. LIMK2-1, a new primate-specific isoform of LIMK2, is associated with intellectual disability. 10 th FENS (Forum of Neurosciences), Jul 2016, Copenhague, Denmark. ⟨hal-02453486⟩
  • A. Champiré, A. Braka, Béatrice Vallée, M. Doudeau, F. Godin, et al.. Conception, synthèse et évaluation biologique d’inhibiteurs de LIM kinases. 29e colloque de Biotechnocentre, Oct 2016, Seillac, France. ⟨hal-02904847⟩

BÉNÉDETTI Hélène

email : helene.benedetti[remplacer_par_at]cnrs-orleans.fr

Phone : +33 2.38.25.55.84

Research director, co-coordinator of the team “Cell biology, Molecular Targets and innovative therapies” and co-responsible of the thematic group “Cell signalling and neurofibromatosis”

 



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