MOSRIN-HUAMAN Christine

email : christine.mosrin@cnrs-orleans.fr

Phone : +33 2.38.25.76.11

Office D116

Researcher within the thematic group “Pharmacological targets and biomarkers

 



19 documents

Article dans une revue

  • Kévin Moreau, Aurélia Le Dantec, Christine Mosrin-Huaman, Yves Bigot, Benoit Piegu, et al.. Perturbation of mRNP biogenesis reveals a dynamic landscape of the Rrp6-dependent surveillance machinery trafficking along the yeast genome. RNA Biology, Taylor & Francis, 2019, pp.1-11. ⟨10.1080/15476286.2019.1593745⟩. ⟨hal-02117640⟩
  • Kévin Moreau, Justine Surand, Aurélia Le Dantec, Christine Mosrin-Huaman, Alain Legrand, et al.. Recombinant yeast and human cells as screening tools to search for antibacterial agents targeting the transcription termination factor Rho. Journal of Antibiotics, Nature Publishing Group: Open Access Hybrid Model Option B, 2018, 71 (4), pp.447-455. ⟨hal-01966171⟩
  • Christine Mosrin-Huaman, Nadège Hervouet-Coste, A. Rachid Rahmouni. Co-transcriptional degradation by the 5′-3′ exonuclease Rat1p mediates quality control of HXK1 mRNP biogenesis in S. cerevisiae. RNA Biology, Taylor & Francis, 2016, 13 (6), pp.582 - 592. ⟨10.1080/15476286.2016.1181255⟩. ⟨hal-01407513⟩
  • Rachid A. Rahmouni, Christine Mosrin-Huaman. In Situ Footprinting of E. coli Transcription Elongation Complex with Chloroacetaldehyde. Methods in Molecular Biology, Humana Press/Springer Imprint, 2015, Methods in Molecular Biology, 1276, pp.229-240. ⟨10.1007/978-1-4939-2392-2_13⟩. ⟨hal-01171857⟩
  • Christine Mosrin-Huaman, Nadege Hervouet-Coste, Aurélia Le Dantec, Igor Stuparevic, A. Rachid Rahmouni. Bacterial Rho helicase: a new tool to dissect mRNP biogenesis and quality control in yeast. Trends in cell and molecular biology, Research Trends, 2014, 9, pp.79 - 93. ⟨hal-01179495⟩
  • Igor Stuparevic, Christine Mosrin-Huaman, Nadège Hervouet-Coste, Mateja Remenaric, A. Rachid Rahmouni. Co-transcriptional recruitment of the RNA exosome cofactors Rrp47p, Mpp6p and two distinct TRAMP complexes assists the exonuclease Rrp6p in the targeting and degradation of an aberrant mRNP in yeast. Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 2013, ⟨10.1074/jbc.M113.491290⟩. ⟨hal-00874892⟩
  • Romy Honorine, Christine Mosrin-Huaman, Nadege Hervouet-Coste, Domenico Libri, Rachid A. Rahmouni. Nuclear mRNA quality control in yeast is mediated by Nrd1 co-transcriptional recruitment, as revealed by the targeting of Rho-induced aberrant transcripts. Nucleic Acids Research, Oxford University Press, 2011, 39 (7), pp.2809-2820. ⟨10.1093/nar/gkq1192⟩. ⟨hal-00602376⟩
  • Christine Mosrin-Huaman, Romy Honorine, A. Rachid Rahmouni. Expression of Bacterial Rho Factor in Yeast Identifies New Factors Involved in the Functional Interplay between Transcription and mRNP Biogenesis. Molecular and Cellular Biology, American Society for Microbiology, 2009, 29 (15), pp.4033-4044. ⟨10.1128/MCB.00272-09⟩. ⟨hal-00525149⟩
  • F. ToulmÉ, C. Mosrin-Huaman, I. Artsimovitch, A.R. Rahmouni. Transcriptional pausing in vivo: a nascent RNA hairpin restricts lateral movements of RNA polymerase in both forward and reverse directions. Journal of Molecular Biology, Elsevier, 2005, 351, pp.39-51. ⟨hal-00088714⟩
  • C. Mosrin-Huaman, C.L. Turnbough, A.R. Rahmouni. Translocation of Escherichia coli RNA polymerase against a protein roadblock in vivo highlights a passive sliding mechanism for transcript elongation. Molecular Microbiology, Wiley, 2004, 51, pp.1471-1481. ⟨hal-00113075⟩
  • M. Decoville, M Giraud-Panis, M Mosrin-Huaman, M. Leng, D. Locker. HMG boxes of DSP1 protein interact with the Rel homology domain of transcription factors. Nucleic Acids Research, Oxford University Press, 2000, 28 (2), pp.454-462. ⟨10.1093/nar/28.2.454⟩. ⟨hal-02119310⟩
  • F Toulmé, M Mosrin-Huaman, J Sparkowski, A. Das, M. Leng, et al.. GreA and GreB proteins revive backtracked RNA polymerase in vivo by promoting transcript trimming. EMBO Journal, EMBO Press, 2000, 19 (24), pp.6853-6859. ⟨10.1093/emboj/19.24.6853⟩. ⟨hal-02127250⟩
  • M Mosrin-Huaman, L. Canaple, D. Locker, M. Decoville. DSP1Gene ofDrosophila melanogaster encodes an HMG-domain protein that plays multiple roles in development. Developmental Genetics, John Wiley & Sons, 1998, 23 (4), pp.324-334. 3.0.CO;2-T">⟨10.1002/(SICI)1520-6408(1998)23:4<324::AID-DVG7>3.0.CO;2-T⟩. ⟨hal-02119315⟩
  • Christine Mosrin-Huaman, M. Riva, M Beltrame, E Cassar, A. Sentenac, et al.. The RPC31 gene of Saccharomyces cerevisiae encodes a subunit of RNA polymerase C (III) with an acidic tail.. Molecular and Cellular Biology, American Society for Microbiology, 1990, 10 (9), pp.4737-4743. ⟨10.1128/mcb.10.9.4737⟩. ⟨hal-02266468⟩
  • Christine Mosrin-Huaman, P Thuriaux. The genetics of RNA polymerases in yeasts.. Current Genetics, Springer Verlag, 1990, 17 (5), pp.367-373. ⟨hal-02266470⟩
  • Sabine Kreps, Fabrice Ferino, Christine Mosrin-Huaman, Jozef Gerits, Max Mergeay, et al.. Conjugative transfer and autonomous replication of a promiscuous IncQ plasmid in the cyanobacterium Synechocystis PCC 6803. Molecular and General Genetics MGG, Springer Verlag, 1990, 221 (1), pp.129-133. ⟨10.1007/BF00280378⟩. ⟨hal-02266473⟩

Chapitre d'ouvrage

  • D. Gallwitz, J. Becker, M. Benli, L. Hengst, C. Mosrin-Huaman, et al.. The YPT-Branch of the ras Superfamily of GTP-Binding Proteins in Yeast: Functional Importance of the Putative Effector Region. The Superfamily of ras-Related Genes, Springer US, pp.121-128, 1991, 978-1-4684-6020-9. ⟨hal-02181563⟩
  • P. Thuriaux, Christine Mosrin-Huaman. La génétique moléculaire des levures. Biotechnologie des levures, elsevier masson, pp.49-80, 1991. ⟨hal-02181574⟩
  • Christine Mosrin-Huaman, P. Thuriaux. Les outils du génie génétique. Biotechnologies des levures, Masson, pp.81-96, 1991. ⟨hal-02266466⟩

 

VALLÉE-MEHEUST Béatrice

 

email : beatrice.vallee@cnrs-orleans.fr

Phone : +33 2.38.25.76.11

Office D113

Researcher within the thematic group “Pharmacological targets and biomarkers

 



19 documents

Article dans une revue

  • Béatrice Vallée, Michel Doudeau, Fabienne Godin, Hélène Bénédetti. Characterization at the Molecular Level using Robust Biochemical Approaches of a New Kinase Protein. Journal of visualized experiments : JoVE, JoVE, 2019, pp.e59820. ⟨10.3791/59820⟩. ⟨hal-02282630⟩
  • Julie Tastet, Hélène Cuberos, Béatrice Vallée, Annick Toutain, Martine Raynaud, et al.. LIMK2-1 is a Hominidae-Specific Isoform of LIMK2 Expressed in Central Nervous System and Associated with Intellectual Disability. Neuroscience, Elsevier - International Brain Research Organization, 2019, 399, pp.199-210. ⟨10.1016/j.neuroscience.2018.12.017⟩. ⟨hal-02067472⟩
  • Béatrice Vallée, Hélène Cuberos, Michel Doudeau, Fabienne Godin, David Gosset, et al.. LIMK2-1, a new isoform of human LIMK2, regulates actin cytoskeleton remodeling via a different signaling pathway than that of its two homologs, LIMK2a and LIMK2b. Biochemical Journal, Portland Press, 2018, 475 (23), pp.3745-3761. ⟨hal-01966439⟩
  • A. de Cola, M. Franceschini, A. Di Matteo, G. Colotti, R. Celani, et al.. N6L pseudopeptide interferes with nucleophosmin protein-protein interactions and sensitizes leukemic cells to chemotherapy. Cancer Letters, Elsevier, 2018, 412, pp.272-282. ⟨10.1016/j.canlet.2017.10.038⟩. ⟨hal-02350445⟩
  • H. Cuberos, B. VallÉe, P. Vourc'H, J. Tastet, C.R. Andres, et al.. Roles of LIM kinases in central nervous system function and dysfunction. FEBS Letters, Wiley, 2015, 589 (24PartB), pp.3795-3806. ⟨10.1016/j.febslet.2015.10.032⟩. ⟨hal-02072231⟩
  • Béatrice Vallée, Michel Doudeau, Fabienne Godin, Aurélie Gombault, Aurélie Tchalikian, et al.. Nf1 RasGAP inhibition of LIMK2 mediates a new cross-talk between Ras and Rho pathways.. PLoS ONE, Public Library of Science, 2012, 7 (10), pp.e47283. ⟨10.1371/journal.pone.0047283⟩. ⟨hal-00817355⟩
  • Fabienne Godin, Sandrine Villette, Béatrice Vallée, Michel Doudeau, Séverine Morisset-Lopez, et al.. A fraction of neurofibromin interacts with PML bodies in the nucleus of the CCF astrocytoma cell line.. Biochemical and Biophysical Research Communications, Elsevier, 2012, 418 (4), pp.689-94. ⟨10.1016/j.bbrc.2012.01.079⟩. ⟨hal-00721861⟩
  • Julie Tastet, Patrick Vourc'H, Frédéric Laumonnier, Béatrice Vallée, Carole Michelle, et al.. LIMK2d, a truncated isoform of Lim kinase 2 regulates neurite growth in absence of the LIM kinase domain. Biochemical and Biophysical Research Communications, Elsevier, 2012, 420 (2), pp.247-252. ⟨10.1016/j.bbrc.2012.02.134⟩. ⟨hal-01136281⟩
  • Martine Beaufour, Fabienne Godin, Béatrice Vallée, Martine Cadene, Hélène Bénédetti. Interaction Proteomics Suggests a New Role for the Tfs1 Protein in Yeast.. Journal of Proteome Research, American Chemical Society, 2012, 11 (6), pp.3211-3218. ⟨10.1021/pr201239t⟩. ⟨hal-00721771⟩
  • Aurélie Gombault, Jonas Warringer, Robert Caesar, Fabienne Godin, Béatrice Vallée, et al.. A phenotypic study of TFS1 mutants differentially altered in the inhibition of Ira2p or CPY. FEMS Yeast Research, Oxford University Press (OUP), 2009, 9 (6), pp.867-874. ⟨10.1111/j.1567-1364.2009.00535.x⟩. ⟨hal-00522432⟩
  • Aurélie Gombault, Fabienne Godin, Denise Sy, Baptiste Legrand, Hélène Chautard, et al.. Molecular Basis of the Tfs1/Ira2 Interaction: A Combined Protein Engineering and Molecular Modelling Study. Journal of Molecular Biology, Elsevier, 2007, 374 (3), pp.604-617. ⟨10.1016/j.jmb.2007.09.057⟩. ⟨hal-00181161⟩
  • Béatrice Vallée, H. Riezman. Lip 1p: a novel subunit of acyl-CoA ceramide synthase. EMBO Journal, EMBO Press, 2005, 24, pp.730-741. ⟨hal-00088715⟩
  • Kouichi Funato, Ruben Lombardi, Béatrice Vallée, Howard Riezman. Lcb4p Is a Key Regulator of Ceramide Synthesis from Exogenous Long Chain Sphingoid Base in Saccharomyces cerevisiae. Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 2003, 278 (9), pp.7325-7334. ⟨10.1074/jbc.M209925200⟩. ⟨hal-02118660⟩
  • Béatrice Vallée, G Coadou, H. Labbé, D. Sy, F. Vovelle, et al.. Peptides corresponding to the N- and C-terminal parts of PEBP are well-structured in solution: new insights into their possible interaction with partners in vivo.. Journal of Peptide Research, Wiley-Blackwell, 2003, 61 (2), pp.47-57. ⟨hal-02118669⟩
  • Kouichi Funato, Béatrice Vallée, Howard Riezman. Biosynthesis and Trafficking of Sphingolipids in the Yeast Saccharomyces cerevisiae †. Biochemistry, American Chemical Society, 2002, 41 (51), pp.15105-15114. ⟨10.1021/bi026616d⟩. ⟨hal-02118664⟩
  • Béatrice Vallée, P Tauc, J Brochon, M Maget-Dana, D. Lelièvre, et al.. Behaviour of bovine phosphatidylethanolamine-binding protein with model membranes. Evidence of affinity for negatively charged membranes.. European Journal of Biochemistry, Wiley, 2001, 268 (22), pp.5831-41. ⟨hal-02118681⟩
  • D Schorling, Béatrice Vallée, Wolfgang Barz, Howard Riezman, Dieter Oesterhelt. Lag1p and Lac1p Are Essential for the Acyl-CoA–dependent Ceramide Synthase Reaction in Saccharomyces cerevisae. Molecular Biology of the Cell, American Society for Cell Biology, 2001, 12 (11), pp.3417-3427. ⟨10.1091/mbc.12.11.3417⟩. ⟨hal-02118674⟩
  • Béatrice Vallée, C. Teyssier, R. Maget-Dana, J. Ramstein, N. Bureaud, et al.. Stability and physicochemical properties of the bovine brain phosphatidylethanolamine-binding protein.. European Journal of Biochemistry, Wiley, 1999, 266 (1), pp.40-52. ⟨hal-02118686⟩
  • C. Serre, Béatrice Vallée, N. Bureaud, F. Schoentgen, C. Zelwer. Crystal structure of the phosphatidylethanolamine-binding protein from bovine brain: a novel structural class of phospholipid-binding proteins.. Structure, Elsevier (Cell Press), 1998, 6 (10), pp.1255-65. ⟨hal-02118689⟩

GODIN Fabienne

email : fabienne.godin@cnrs-orleans.fr

Phone : +33 2.38.25.76.05

Office D110

Engineer in biological techniques within the thematic group Cell signalling and neurofibromatosis

 



9 documents

Article dans une revue

  • Béatrice Vallée, Michel Doudeau, Fabienne Godin, Hélène Bénédetti. Characterization at the Molecular Level using Robust Biochemical Approaches of a New Kinase Protein. Journal of visualized experiments : JoVE, JoVE, 2019, pp.e59820. ⟨10.3791/59820⟩. ⟨hal-02282630⟩
  • Béatrice Vallée, Hélène Cuberos, Michel Doudeau, Fabienne Godin, David Gosset, et al.. LIMK2-1, a new isoform of human LIMK2, regulates actin cytoskeleton remodeling via a different signaling pathway than that of its two homologs, LIMK2a and LIMK2b. Biochemical Journal, Portland Press, 2018, 475 (23), pp.3745-3761. ⟨hal-01966439⟩
  • L Cobret, M L de Tauzia, J Ferent, E Traiffort, I Hénaoui, et al.. Targeting the cis-dimerization of LINGO-1 with low MW compounds affects its downstream signalling. British Journal of Clinical Pharmacology, Wiley, 2015, 172 (3), pp.841-856. ⟨10.1111/bph.12945⟩. ⟨hal-01170735⟩
  • Béatrice Vallée, Michel Doudeau, Fabienne Godin, Aurélie Gombault, Aurélie Tchalikian, et al.. Nf1 RasGAP inhibition of LIMK2 mediates a new cross-talk between Ras and Rho pathways.. PLoS ONE, Public Library of Science, 2012, 7 (10), pp.e47283. ⟨10.1371/journal.pone.0047283⟩. ⟨hal-00817355⟩
  • Fabienne Godin, Sandrine Villette, Béatrice Vallée, Michel Doudeau, Séverine Morisset-Lopez, et al.. A fraction of neurofibromin interacts with PML bodies in the nucleus of the CCF astrocytoma cell line.. Biochemical and Biophysical Research Communications, Elsevier, 2012, 418 (4), pp.689-94. ⟨10.1016/j.bbrc.2012.01.079⟩. ⟨hal-00721861⟩
  • Martine Beaufour, Fabienne Godin, Béatrice Vallée, Martine Cadene, Hélène Bénédetti. Interaction Proteomics Suggests a New Role for the Tfs1 Protein in Yeast.. Journal of Proteome Research, American Chemical Society, 2012, 11 (6), pp.3211-3218. ⟨10.1021/pr201239t⟩. ⟨hal-00721771⟩
  • Aurélie Gombault, Jonas Warringer, Robert Caesar, Fabienne Godin, Béatrice Vallée, et al.. A phenotypic study of TFS1 mutants differentially altered in the inhibition of Ira2p or CPY. FEMS Yeast Research, Oxford University Press (OUP), 2009, 9 (6), pp.867-874. ⟨10.1111/j.1567-1364.2009.00535.x⟩. ⟨hal-00522432⟩
  • Aurélie Gombault, Fabienne Godin, Denise Sy, Baptiste Legrand, Hélène Chautard, et al.. Molecular Basis of the Tfs1/Ira2 Interaction: A Combined Protein Engineering and Molecular Modelling Study. Journal of Molecular Biology, Elsevier, 2007, 374 (3), pp.604-617. ⟨10.1016/j.jmb.2007.09.057⟩. ⟨hal-00181161⟩
  • Pierre L. Roubertoux, F Sluyter, Michèle Carlier, B Marcet, F Maarouf-Veray, et al.. Mitochondrial DNA modifies cognition in interaction with the nuclear genome and age in mice. Nature Genetics, Nature Publishing Group, 2003, 35 (1), pp.65-69. ⟨10.1038/ng1230⟩. ⟨hal-01441349⟩

DOUDEAU Michel

email : michel.doudeau@cnrs-orleans.fr

Phone : +33 2.38.25.76.05

Office D113

Assistant engineer in biology, Natural sciences within the thematic group “Cell signalling and neurofibromatosis”

 



6 documents

Article dans une revue

  • Béatrice Vallée, Michel Doudeau, Fabienne Godin, Hélène Bénédetti. Characterization at the Molecular Level using Robust Biochemical Approaches of a New Kinase Protein. Journal of visualized experiments : JoVE, JoVE, 2019, pp.e59820. ⟨10.3791/59820⟩. ⟨hal-02282630⟩
  • Béatrice Vallée, Hélène Cuberos, Michel Doudeau, Fabienne Godin, David Gosset, et al.. LIMK2-1, a new isoform of human LIMK2, regulates actin cytoskeleton remodeling via a different signaling pathway than that of its two homologs, LIMK2a and LIMK2b. Biochemical Journal, Portland Press, 2018, 475 (23), pp.3745-3761. ⟨hal-01966439⟩
  • Béatrice Vallée, Michel Doudeau, Fabienne Godin, Aurélie Gombault, Aurélie Tchalikian, et al.. Nf1 RasGAP inhibition of LIMK2 mediates a new cross-talk between Ras and Rho pathways.. PLoS ONE, Public Library of Science, 2012, 7 (10), pp.e47283. ⟨10.1371/journal.pone.0047283⟩. ⟨hal-00817355⟩
  • Fabienne Godin, Sandrine Villette, Béatrice Vallée, Michel Doudeau, Séverine Morisset-Lopez, et al.. A fraction of neurofibromin interacts with PML bodies in the nucleus of the CCF astrocytoma cell line.. Biochemical and Biophysical Research Communications, Elsevier, 2012, 418 (4), pp.689-94. ⟨10.1016/j.bbrc.2012.01.079⟩. ⟨hal-00721861⟩
  • Aurélie Gombault, Jonas Warringer, Robert Caesar, Fabienne Godin, Béatrice Vallée, et al.. A phenotypic study of TFS1 mutants differentially altered in the inhibition of Ira2p or CPY. FEMS Yeast Research, Oxford University Press (OUP), 2009, 9 (6), pp.867-874. ⟨10.1111/j.1567-1364.2009.00535.x⟩. ⟨hal-00522432⟩
  • Simon Amiard, Michel Doudeau, Sébastien Pinte, Anaïs Poulet, Christelle Lenain, et al.. A topological mechanism for TRF2-enhanced strand invasion. Nature Structural and Molecular Biology, Nature Publishing Group, 2007, 14 (2), pp.147-154. ⟨10.1038/nsmb1192⟩. ⟨hal-00158337⟩

BÉNÉDETTI Hélène

email : helene.benedetti@cnrs-orleans.fr

Phone : +33 2.38.25.55.84

Office D111

Research director, co-coordinator of the team “Cell biology, Molecular Targets and innovative therapies” and co-responsible of the thematic group “Cell signalling and neurofibromatosis”

 



67 documents

Article dans une revue

  • Béatrice Vallée, Michel Doudeau, Fabienne Godin, Hélène Bénédetti. Characterization at the Molecular Level using Robust Biochemical Approaches of a New Kinase Protein. Journal of visualized experiments : JoVE, JoVE, 2019, pp.e59820. ⟨10.3791/59820⟩. ⟨hal-02282630⟩
  • Julie Tastet, Hélène Cuberos, Béatrice Vallée, Annick Toutain, Martine Raynaud, et al.. LIMK2-1 is a Hominidae-Specific Isoform of LIMK2 Expressed in Central Nervous System and Associated with Intellectual Disability. Neuroscience, Elsevier - International Brain Research Organization, 2019, 399, pp.199-210. ⟨10.1016/j.neuroscience.2018.12.017⟩. ⟨hal-02067472⟩
  • Béatrice Vallée, Hélène Cuberos, Michel Doudeau, Fabienne Godin, David Gosset, et al.. LIMK2-1, a new isoform of human LIMK2, regulates actin cytoskeleton remodeling via a different signaling pathway than that of its two homologs, LIMK2a and LIMK2b. Biochemical Journal, Portland Press, 2018, 475 (23), pp.3745-3761. ⟨hal-01966439⟩
  • Viorel Simion, Wissem Deraredj Nadim, Hélène Bénédetti, Chantal Pichon, Séverine Morisset-Lopez, et al.. Pharmacomodulation of microRNA Expression in Neurocognitive Diseases: Obstacles and Future Opportunities. Current Neuropharmacology, Bentham Science Publishers, 2017, 15 (2), pp.276 - 290. ⟨10.2174/1570159X14666160630210422⟩. ⟨hal-01618771⟩
  • Wissem Deraredj Nadim, Simion Viorel, Hélène Bénédetti, Chantal Pichon, Patrick Baril, et al.. MicroRNAs in Neurocognitive Dysfunctions: New Molecular Targets for Pharmacological Treatments?. Current Neuropharmacology, Bentham Science Publishers, 2017, 15 (2), pp.260 - 275. ⟨10.2174/1570159X14666160709001441⟩. ⟨hal-01618199⟩
  • Wissem Deraredj Nadim, Séverine Chaumont-Dubel, Fahima Madouri, Laetitia Cobret, Marie-Ludivine de Tauzia, et al.. Physical interaction between neurofibromin and serotonin 5-HT 6 receptor promotes receptor constitutive activity. Proceedings of the National Academy of Sciences of the United States of America , National Academy of Sciences, 2016, 113 (43), pp.12310 - 12315. ⟨10.1073/pnas.1600914113⟩. ⟨hal-01407899⟩
  • L Cobret, M L de Tauzia, J Ferent, E Traiffort, I Hénaoui, et al.. Targeting the cis-dimerization of LINGO-1 with low MW compounds affects its downstream signalling. British Journal of Clinical Pharmacology, Wiley, 2015, 172 (3), pp.841-856. ⟨10.1111/bph.12945⟩. ⟨hal-01170735⟩
  • Julie Tastet, Loïc Decalonne, Sylviane Marouillat, Joëlle Malvy, Rose-Anne Thépault, et al.. Mutation screening of the ubiquitin ligase gene RNF135 in French patients with autism. Psychiatric Genetics, Lippincott, Williams & Wilkins, 2015, 25 (6), pp.263-267. ⟨10.1097/ypg.0000000000000100⟩. ⟨hal-02072312⟩
  • H. Cuberos, B. VallÉe, P. Vourc'H, J. Tastet, C.R. Andres, et al.. Roles of LIM kinases in central nervous system function and dysfunction. FEBS Letters, Wiley, 2015, 589 (24PartB), pp.3795-3806. ⟨10.1016/j.febslet.2015.10.032⟩. ⟨hal-02072231⟩
  • Thibault Saurat, Frédéric Buron, Nuno Rodrigues, Marie-Ludivine de Tauzia, Lionel Colliandre, et al.. Design, Synthesis, and Biological Activity of Pyridopyrimidine Scaffolds as Novel PI3K/mTOR Dual Inhibitors. Journal of Medicinal Chemistry, American Chemical Society, 2014, 57 (3), pp.613-631. ⟨10.1021/jm401138v⟩. ⟨hal-01180887⟩
  • Solene Guiheneuf, Ludovic Paquin, Francois Carreaux, Emilie Durieu, Helene Benedetti, et al.. Microwave Assisted Organic Synthesis (MAOS) of New Dispacamide A Derivatives Bearing a Thiazolinone Platform, Biological Assays on Inhibition of Protein Kinases and Cell Effects. Current microwave chemistry, 2014, 1 (1), pp.33-40. ⟨10.2174/22133356114019990002⟩. ⟨hal-01114583⟩
  • Reine Nehmé, Hala Nehmé, Thibault Saurat, Marie-Ludivine De-Tauzia, Frédéric Buron, et al.. New in-capillary electrophoretic kinase assays to evaluate inhibitors of the PI3k/Akt/mTOR signaling pathway.. Analytical and Bioanalytical Chemistry, Springer Verlag, 2014, 406 (15), pp.3743-3754. ⟨hal-01180770⟩
  • Amélie Bruel, Romain Bénéteau, Mylène Chabanne, Olivier Lozach, Rémy Le Guevel, et al.. Synthesis of new pyridazino[4,5-b]indol-4-ones and pyridazin-3(2H)-one analogs as DYRK1A inhibitors. Bioorganic and Medicinal Chemistry Letters, Elsevier, 2014, 24 (21), pp.5037 - 5040. ⟨10.1016/j.bmcl.2014.09.017⟩. ⟨hal-01086026⟩
  • François Hericourt, François Chefdor, Lucie Bertheau, Mirai Tanigawa, Tatsuya Maeda, et al.. Characterization of histidine-aspartate kinase HK1 and identification of histidine phosphotransfer proteins as potential partners in a Populus multistep phosphorelay. Physiologia Plantarum, Wiley, 2013, 149 (2), pp.188-199. ⟨10.1111/ppl.12024⟩. ⟨hal-02070851⟩
  • Béatrice Vallée, Michel Doudeau, Fabienne Godin, Aurélie Gombault, Aurélie Tchalikian, et al.. Nf1 RasGAP inhibition of LIMK2 mediates a new cross-talk between Ras and Rho pathways.. PLoS ONE, Public Library of Science, 2012, 7 (10), pp.e47283. ⟨10.1371/journal.pone.0047283⟩. ⟨hal-00817355⟩
  • Fabienne Godin, Sandrine Villette, Béatrice Vallée, Michel Doudeau, Séverine Morisset-Lopez, et al.. A fraction of neurofibromin interacts with PML bodies in the nucleus of the CCF astrocytoma cell line.. Biochemical and Biophysical Research Communications, Elsevier, 2012, 418 (4), pp.689-94. ⟨10.1016/j.bbrc.2012.01.079⟩. ⟨hal-00721861⟩
  • Dominique Arnaud, Annabelle Déjardin, Jean-Charles Leplé, Marie-Claude Lesage-Descauses, Nathalie Boizot, et al.. Expression analysis of LIM gene family in poplar, toward an updated phylogenetic classification.. BMC Research Notes, BioMed Central, 2012, 5, pp.102. ⟨10.1186/1756-0500-5-102⟩. ⟨hal-00721759⟩
  • Julie Tastet, Patrick Vourc'H, Frédéric Laumonnier, Béatrice Vallée, Carole Michelle, et al.. LIMK2d, a truncated isoform of Lim kinase 2 regulates neurite growth in absence of the LIM kinase domain. Biochemical and Biophysical Research Communications, Elsevier, 2012, 420 (2), pp.247-252. ⟨10.1016/j.bbrc.2012.02.134⟩. ⟨hal-01136281⟩
  • A. Bruel, Cedric Logé, M.-L. de Tauzia, M. Ravache, R. Le Guevel, et al.. Synthesis and biological evaluation of new 5-benzylated 4-oxo-3,4-dihydro-5Hpyridazino[4,5-b]indoles as PI3Ka inhibitors.. European Journal of Medicinal Chemistry, Elsevier, 2012, 57, pp.225-233. ⟨hal-00764872⟩
  • Martine Beaufour, Fabienne Godin, Béatrice Vallée, Martine Cadene, Hélène Bénédetti. Interaction Proteomics Suggests a New Role for the Tfs1 Protein in Yeast.. Journal of Proteome Research, American Chemical Society, 2012, 11 (6), pp.3211-3218. ⟨10.1021/pr201239t⟩. ⟨hal-00721771⟩
  • Aurélie Gombault, Jonas Warringer, Robert Caesar, Fabienne Godin, Béatrice Vallée, et al.. A phenotypic study of TFS1 mutants differentially altered in the inhibition of Ira2p or CPY. FEMS Yeast Research, Oxford University Press (OUP), 2009, 9 (6), pp.867-874. ⟨10.1111/j.1567-1364.2009.00535.x⟩. ⟨hal-00522432⟩
  • Aurélie Gombault, Fabienne Godin, Denise Sy, Baptiste Legrand, Hélène Chautard, et al.. Molecular Basis of the Tfs1/Ira2 Interaction: A Combined Protein Engineering and Molecular Modelling Study. Journal of Molecular Biology, Elsevier, 2007, 374 (3), pp.604-617. ⟨10.1016/j.jmb.2007.09.057⟩. ⟨hal-00181161⟩
  • F. Chefdor, H. BÉnÉdetti, C. Depierreux, Franck Delmotte, D. Morabito, et al.. Osmotic stress sensing in Populus: components identification of a phosphorelay system. FEBS Letters, Wiley, 2006, 580 (1), pp.77-81. ⟨10.1016/j.febslet.2005.11.051⟩. ⟨hal-00088838⟩
  • S. Quevillon-Cheruel, N. Leulliot, M. Graille, N. Hervouet, F. Coste, et al.. Crystal structure of yeast YHR049W/FSH1, a member of the serine hydrolase family. Protein science : a publication of the Protein Society., 2005, 14, pp.1350-1356. ⟨hal-00088667⟩
  • S. Castella, Hélène Bénédetti, R. de Llorens, J.L. Dacheux, F. Dacheux. Train A, an RNase-A-like protein without RNase activity is secreted and reabsorbed by the same epididymal cells under testicular control. Biology of Reproduction, Society for the Study of Reproduction, 2004, 71 (5), pp.1677-1687. ⟨10.1095/biolreprod.104.031666⟩. ⟨hal-00112960⟩
  • H. Chautard, M. Jacquer, F. Schoentgen, N. Bureaud, H. BÉnÉdetti. Tfs1, a member of the PEBP family, inhibits the Ira2p but not the Ira1p Ras GTPase activating protein in Saccharomyces cerevisiae. Eukaryotic Cell, American Society for Microbiology, 2004, 3 (2), pp.459-470. ⟨10.1128/EC.3.2.459-470.2004⟩. ⟨hal-00112967⟩
  • Emmanuelle Bouveret, Laure Journet, Anne Walburger, Eric Cascales, Hélène Bénédetti, et al.. Analysis of the Escherichia coli Tol-Pal and TonB systems by periplasmic production of Tol, TonB, colicin, or phage capsid soluble domains.. Biochimie, Elsevier, 2002, 84 (5-6), pp.413-21. ⟨hal-02130103⟩
  • Laurence Serre, F Serre, Charles Zelwer, Nicole Bureaud, Francoise Schoentgen, et al.. Crystal structures of YBHB and YBCL from Escherichia coli , two bacterial homologues to a Raf kinase inhibitor protein 1 1Edited by R. Huber. Journal of Molecular Biology, Elsevier, 2001, 310 (3), pp.617-634. ⟨10.1006/jmbi.2001.4784⟩. ⟨hal-02130120⟩
  • L. Journet, E. Bouveret, A. Rigal, R Lloubes, C Lazdunski, et al.. Import of colicins across the outer membrane of Escherichia coli involves multiple protein interactions in the periplasm.. Molecular Microbiology, Wiley, 2001, 42 (2), pp.331-44. ⟨hal-02130124⟩
  • C. Lazdunski, E. Bouveret, A Rigal, L. Journet, R. Lloubes, et al.. Colicin import into Escherichia coli cells requires the proximity of the inner and outer membranes and other factors. International Journal of Medical Microbiology, Elsevier, 2000, 290 (4-5), pp.337-344. ⟨10.1016/S1438-4221(00)80037-5⟩. ⟨hal-02130686⟩
  • E Bouveret, H Bénédetti, A Rigal, E. Loret, C Lazdunski. In vitro characterization of peptidoglycan-associated lipoprotein (PAL)-peptidoglycan and PAL-TolB interactions.. Journal of Bacteriology, American Society for Microbiology, 1999, 181 (20), pp.6306-11. ⟨hal-02130134⟩
  • Laure Journet, A Rigal, C Lazdunski, H Bénédetti. Role of TolR N-terminal, central, and C-terminal domains in dimerization and interaction with TolA and tolQ.. Journal of Bacteriology, American Society for Microbiology, 1999, 181 (15), pp.4476-84. ⟨hal-02130149⟩
  • Chantal Abergel, E. Bouveret, J.M Claverie, K Brown, A Rigal, et al.. Structure of the Escherichia coli TolB protein determined by MAD methods at 1.95 A resolution.. Structure, Elsevier (Cell Press), 1999, 7 (10), pp.1291-300. ⟨hal-02130130⟩
  • C.J Lazdunski, E. Bouveret, A. Rigal, L. Journet, R Lloubès, et al.. Colicin import into Escherichia coli cells.. Journal of Bacteriology, American Society for Microbiology, 1998, 180 (19), pp.4993-5002. ⟨hal-02130152⟩
  • Chantal Abergel, A Rigal, S Chenivesse, C Lazdunski, J.M Claverie, et al.. Crystallization and preliminary crystallographic study of a component of the Escherichia coli tol system: TolB.. Acta Crystallographica Section D: Biological Crystallography, International Union of Crystallography, 1998, 54 (Pt 1), pp.102-4. ⟨hal-02130160⟩
  • E Bouveret, A Rigal, C Lazdunski, H Bénédetti. Distinct regions of the colicin A translocation domain are involved in the interaction with TolA and TolB proteins upon import into Escherichia coli.. Molecular Microbiology, Wiley, 1998, 27 (1), pp.143-57. ⟨hal-02130155⟩
  • A Rigal, E. Bouveret, R Lloubes, C Lazdunski, H Bénédetti. The TolB protein interacts with the porins of Escherichia coli.. Journal of Bacteriology, American Society for Microbiology, 1997, 179 (23), pp.7274-7279. ⟨10.1128/jb.179.23.7274-7279.1997⟩. ⟨hal-02130169⟩
  • E Bouveret, A Rigal, C Lazdunski, H Bénédetti. The N-terminal domain of colicin E3 interacts with TolB which is involved in the colicin translocation step.. Molecular Microbiology, Wiley, 1997, 23 (5), pp.909-20. ⟨hal-02130173⟩
  • R Derouiche, M Gavioli, H Bénédetti, A Prilipov, C Lazdunski, et al.. TolA central domain interacts with Escherichia coli porins.. EMBO Journal, EMBO Press, 1996, 15 (23), pp.6408-15. ⟨hal-02130175⟩
  • D. Duche, L. Letellier, V Géli, H Bénédetti, D. Baty. Quantification of group A colicin import sites.. Journal of Bacteriology, American Society for Microbiology, 1995, 177 (17), pp.4935-4939. ⟨10.1128/jb.177.17.4935-4939.1995⟩. ⟨hal-02130183⟩
  • D. Duche, L. Letellier, V. Geli, H. BÉnÉdetti, D. Baty. Quantification of group A colicin import sites.. Journal of Bacteriology, American Society for Microbiology, 1995, 177 (17), pp.4935-4939. ⟨10.1128/jb.177.17.4935-4939.1995⟩. ⟨hal-02440962⟩
  • R Derouiche, H Bénédetti, Jc Lazzaroni, C Lazdunski, R Lloubès. Protein complex within Escherichia coli inner membrane. TolA N-terminal domain interacts with TolQ and TolR proteins. Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 1995, 270 (19), pp.11078-11084. ⟨10.1074/jbc.270.19.11078⟩. ⟨hal-02130187⟩
  • E. Bouveret, R Derouiche, R. Rigal, R Lloubès, C Lazdunski, et al.. Peptidoglycan-associated lipoprotein-TolB interaction. A possible key to explaining the formation of contact sites between the inner and outer membranes of Escherichia coli. Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 1995, 270 (19), pp.11071-11077. ⟨10.1074/jbc.270.19.11071⟩. ⟨hal-02130195⟩
  • Jean Claude Lazzaroni, Anne Vianney, V Vianney, Jean Luc Popot, Hélène Bénédetti, et al.. Transmembrane α-Helix Interactions are Required for the Functional Assembly of theEscherichia coliTol Complex. Journal of Molecular Biology, Elsevier, 1995, 246 (1), pp.1-7. ⟨10.1006/jmbi.1994.0058⟩. ⟨hal-02130202⟩
  • G. Guihard, P. Boulanger, H Bénédetti, R Lloubés, M Besnard, et al.. Colicin A and the Tol proteins involved in its translocation are preferentially located in the contact sites between the inner and outer membranes of Escherichia coli cells.. Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 1994, 269 (8), pp.5874-80. ⟨hal-02130218⟩
  • David Espesset, Yves Corda, Kyle Cunningham, Hélène Bénédetti, Roland Lloubes, et al.. The colicin A pore-forming domain fused to mitochondrial intermembrane space sorting signals can be functionally inserted into the Escherichia coli plasma membrane by a mechanism that bypasses the Tol proteins. Molecular Microbiology, Wiley, 1994, 13 (6), pp.1121-1131. ⟨10.1111/j.1365-2958.1994.tb00503.x⟩. ⟨hal-02130213⟩
  • H Bénédetti, S Raths, F Crausaz, H. Riezman. The END3 gene encodes a protein that is required for the internalization step of endocytosis and for actin cytoskeleton organization in yeast.. Molecular Biology of the Cell, American Society for Cell Biology, 1994, 5 (9), pp.1023-37. ⟨hal-02130204⟩
  • G. Guihard, H Bénédetti, M Besnard, L. Letellier. Phosphate efflux through the channels formed by colicins and phage T5 in Escherichia coli cells is responsible for the fall in cytoplasmic ATP.. Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 1993, 268 (24), pp.17775-80. ⟨hal-02130233⟩
  • J Rohrer, H Bénédetti, B Zanolari, H. Riezman. Identification of a novel sequence mediating regulated endocytosis of the G protein-coupled alpha-pheromone receptor in yeast.. Molecular Biology of the Cell, American Society for Cell Biology, 1993, 4 (5), pp.511-21. ⟨hal-02130242⟩
  • V Geli, R Lloubes, S Zaat, R van Spaendonk, C Rollin, et al.. Recognition of the colicin A N-terminal epitope 1C11 in vitro and in vivo in Escherichia coli by its cognate monoclonal antibody. FEMS Microbiology Letters, Wiley-Blackwell, 1993, 109 (2-3), pp.335-342. ⟨10.1016/0378-1097(93)90042-z⟩. ⟨hal-02130222⟩
  • Hélène Bénédetti, R Lloubès, C Lazdunski, L. Letellier. Colicin A unfolds during its translocation in Escherichia coli cells and spans the whole cell envelope when its pore has formed.. EMBO Journal, EMBO Press, 1992, 11 (2), pp.441-7. ⟨hal-02130272⟩
  • Hélène Bénédetti, C Lazdunski, R Lloubès. Protein import into Escherichia coli: colicins A and E1 interact with a component of their translocation system.. EMBO Journal, EMBO Press, 1991, 10 (8), pp.1989-95. ⟨hal-02130277⟩
  • Hélène Bénédetti, M Frenette, D. Baty, M Knibiehler, F. Pattus, et al.. Individual domains of colicins confer specificity in colicin uptake, in pore-properties and in immunity requirement.. Journal of Molecular Biology, Elsevier, 1991, 217 (3), pp.429-39. ⟨hal-02130283⟩
  • M Frenette, H Bénédetti, A. Bernadac, D. Baty, C Lazdunski. Construction, expression and release of hybrid colicins.. Journal of Molecular Biology, Elsevier, 1991, 217 (3), pp.421-8. ⟨hal-02130287⟩
  • D. Baty, F. Pattus, M. Parker, H. BÉnÉdetti, M. Frenette, et al.. Uptake across the cell envelope and insertion into the inner membrane of ion channel-forming colicins in E coli. Biochimie, Elsevier, 1990, 72 (2-3), pp.123-130. ⟨10.1016/0300-9084(90)90137-6⟩. ⟨hal-02130296⟩
  • C. Lazdunski, H Bénédetti. Insertion and translocation of proteins into and through membranes.. FEBS Letters, Wiley, 1990, 268 (2), pp.408-14. ⟨hal-02130669⟩
  • H. BÉnÉdetti, M. Frenette, D. Baty, R Lloubès, V. Geli, et al.. Comparison of the Uptake Systems for the Entry of Various BtuB Group Colicins into Escherichia coli. Microbiology, Microbiology Society, 1989, 135 (12), pp.3413-3420. ⟨10.1099/00221287-135-12-3413⟩. ⟨hal-02130300⟩

Communication dans un congrès

  • Wassim Lakhal, Nathalie Boizot, Marie-Claude Lesage Descauses, Odile Rogier, Véronique Laine-Prade, et al.. Both ChIP-SEQ and in planta gene modification demonstrate the involvement of MYB090 and MYB156 in secondary cell wall formation in poplar. INUPRAG-Meeting 2015, Oct 2015, Nancy, France. ⟨hal-01604786⟩

Chapitre d'ouvrage

  • H. BÉnÉdetti, V. Geli. Colicin transport, channel formation and inhibition. Handbook of Biological Physics, pp.665-691, 1996. ⟨hal-02130677⟩
  • Emmanuelle Bouveret, Claude Lazdunski, Hélène Bénédetti. The Tol/PAL and TonB systems : two envelope-spanning protein complexes involved in colicin import in E. coli.. Molecular Dynamics of Biomembranes, Springer Berlin Heidelberg, pp.59-69, 1996. ⟨hal-02130680⟩
  • Vincent Géli, Hélène Bénédetti. Insertion of Proteins into Membranes A Survey. Membrane biogenesis, pp.21-69, 1994, Subcellular Biochemistry, 978-1-4613-6018-6. ⟨hal-02130265⟩
  • Hélène Bénédetti, Lucienne Letellier, Roland Lloubes, Vincent Géli, Daniel Baty, et al.. Import of Colicins into Escherichia Coli. Dynamics of Membrane Assembly, 63, Springer Berlin Heidelberg, pp.315-332, 1992. ⟨hal-02130670⟩
  • L. Letellier, C. Lazdunski, H. BÉnÉdetti, J. Bourdineaud, P. Boulanger. In Vivo Properties of Colicin A: Channel Activity and Translocation. Bacteriocins, Microcins and Lantibiotics, Springer Berlin Heidelberg, pp.119-125, 1992. ⟨hal-02130671⟩
  • Hélène Bénédetti, Lucienne Letellier, Roland Lloubes, Vincent Géli, Daniel Baty, et al.. Study of the Import Mechanisms of Colicins Through Protein Engineering and K+ Efflux Kinetics. Bacteriocins, Microcins and Lantibiotics, Springer Berlin Heidelberg, pp.215-223, 1992. ⟨hal-02130674⟩
  • C. Lazdunski, D. Baty, V. Geli, R. Lloubes, H. BÉnÉdetti, et al.. Molecular Mechanism of Action of Pore-Forming Colicins and of their Immunity Proteins. Membrane Proteins: Structures, Interactions and Models, pp.413-425, 1992. ⟨hal-02130675⟩

Brevet

  • Sylvain Routier, Hélène Bénédetti, Frederic Buron, Marie-Aude Hiebel, Thibault Saurat, et al.. TRISUBSTITUTED PYRIDO[2,3-D]PYRIMIDINES, METHODS FOR PREPARING SAME AND THERAPEUTIC USES THEREOF. France, Patent n° : WO2014027081. 2014. ⟨hal-02131560⟩
  • Séverine Morisset-Lopez, Hélène Bénédetti. TOOLS FOR THE IDENTIFICATION OF LINGO-1, LINGO-2, LINGO-3 AND LINGO-4, LIGANDS, AND USES THEREOF. France, Patent n° : WO2011121257. 2011. ⟨hal-02130935⟩