COBRET Laëtitia

 

email : laetitia.cobret@cnrs-orleans.fr

Phone : +33 2.38.25.55.51 ou 76.70

Office D

Engineer in biological techniques within the thematic group “RNA remodeling factors and mechanisms”



6 documents

Article dans une revue

  • Sylvain Normand, Nadine Waldschmitt, Andreas Neerincx, Ruben Julio Martinez-Torres, Camille Chauvin, et al.. Proteasomal degradation of NOD2 by NLRP12 in monocytes promotes bacterial tolerance and colonization by enteropathogens. Nature Communications, Nature Publishing Group, 2018, 9 (1), ⟨10.1038/s41467-018-07750-5⟩. ⟨hal-02126569⟩
  • Sylvain Normand, Nadine Waldschmitt, Andre Neerincx, Ruben Martinez-Torres, Camille Chauvin, et al.. Proteasomal degradation of NOD2 by NLRP12 in monocytes promotes bacterial tolerance and colonization by enteropathogens. Nature Communications, Nature Publishing Group, 2018, 9, pp.5338. ⟨10.1038/s41467-018-07750-5⟩. ⟨hal-01976051⟩
  • Fawaz Awad, Eman Assrawi, Claire Jumeau, Sophie Georgin-Lavialle, Laetitia Cobret, et al.. Impact of human monocyte and macrophage polarization on NLR expression and NLRP3 inflammasome activation. PLoS ONE, Public Library of Science, 2017, 12 (4), pp.e0175336. ⟨10.1371/journal.pone.0175336⟩. ⟨hal-01509838⟩
  • Wissem Deraredj Nadim, Séverine Chaumont-Dubel, Fahima Madouri, Laetitia Cobret, Marie-Ludivine de Tauzia, et al.. Physical interaction between neurofibromin and serotonin 5-HT 6 receptor promotes receptor constitutive activity. Proceedings of the National Academy of Sciences of the United States of America , National Academy of Sciences, 2016, 113 (43), pp.12310 - 12315. ⟨10.1073/pnas.1600914113⟩. ⟨hal-01407899⟩
  • L Cobret, M L de Tauzia, J Ferent, E Traiffort, I Hénaoui, et al.. Targeting the cis-dimerization of LINGO-1 with low MW compounds affects its downstream signalling. British Journal of Clinical Pharmacology, Wiley, 2015, 172 (3), pp.841-856. ⟨10.1111/bph.12945⟩. ⟨hal-01170735⟩
  • Denis Saulnier, Sophie de Decker, Philippe Haffner, Laetitia Cobret, Maeva Robert, et al.. A Large-Scale Epidemiological Study to Identify Bacteria Pathogenic to Pacific Oyster Crassostrea gigas and Correlation Between Virulence and Metalloprotease-like Activity. Microbial Ecology, Springer Verlag, 2010, 59 (4), pp.787-798. ⟨10.1007/s00248-009-9620-y⟩. ⟨hal-02114177⟩

MEUDAL Hervé

email : herve.meudal@cnrs-orleans.fr

Phone : +33 2.38.25.55.46 ou 55.63

Office D102

Engineer in chemical analysise within the thematic group “NMR of biomoleculess”

 



30 documents

Article dans une revue

  • Claude Zoukimian, Hervé Meudal, Stephan de Waard, Karima Ait Ouares, Sébastien Nicolas, et al.. Synthesis by native chemical ligation and characterization of the scorpion toxin AmmTx3. Bioorganic & medicinal chemistry, Elsevier, 2019, 27 (1), pp.247-253. ⟨hal-02000140⟩
  • Geoffrey Bailleul, Amanda Kravtzoff, Alix Joulin-Giet, Fabien Lecaille, Valérie Labas, et al.. The unusual resistance of avian defensin AvBD7 to proteolytic enzymes preserves its antibacterial activity. PLoS ONE, Public Library of Science, 2016, 11 (8), pp.1-20. ⟨10.1371/journal.pone.0161573⟩. ⟨hal-01594888⟩
  • Fatima Oukhatar, Hervé Meudal, Céline Landon, Nikos K Logothetis, Carlos Platas-Iglesias, et al.. Macrocyclic Gd(3+) Complexes with Pendant Crown Ethers Designed for Binding Zwitterionic Neurotransmitters.. Chemistry - A European Journal, Wiley-VCH Verlag, 2015, 21 (31), pp.11226-11237. ⟨hal-01196981⟩
  • Virginie Hervé, Hervé Meudal, Valérie Labas, Sophie Réhault-Godbert, Joël Gautron, et al.. Three-dimensional NMR Structure of Hen Egg Gallin (Chicken Ovodefensin) Reveals a New Variation of the β-Defensin Fold. Journal of Biological Physics and Chemistry, Basel, Switzerland : Collegium Basilea (Institute of Advanced Study) ; Tbilisi : Association of Modern Scientific Investigation (AMSI), 2014, 289 (10), pp.7211-20. ⟨10.1074/jbc.M113.507046⟩. ⟨hal-01118312⟩
  • Corinne Buré, Philippe Marceau, Hervé Meudal, Agnès F Delmas. Synthesis and analytical investigation of C-terminally modified peptide aldehydes and ketone: application to oxime ligation.. Journal of Peptide Science, Wiley, 2012, 18 (3), pp.147-54. ⟨10.1002/psc.1429⟩. ⟨hal-00721799⟩
  • Chrystelle Derache, Hervé Meudal, Vincent Aucagne, Kevin J Mark, Martine Cadène, et al.. Initial insights into structure-activity relationships of avian defensins.. Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 2012, 287 (10), pp.7746-55. ⟨10.1074/jbc.M111.312108⟩. ⟨hal-00721842⟩
  • Françoise Paquet, Karine Loth, Hervé Meudal, Francoise Culard, Daniel Genest, et al.. Refined solution structure and backbone dynamics of the archaeal MC1 protein. FEBS Journal, Wiley, 2010, 277 (24), pp.5133-5145. ⟨10.1111/j.1742-4658.2010.07927.x⟩. ⟨hal-00602469⟩
  • Pedro Da Silva, Isabelle Rahioui, Christian Laugier, Laurence Jouvensal, Hervé Meudal, et al.. Molecular requirements for the insecticidal activity of the plant peptide pea albumin 1 subunit b (PA1b).. Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 2010, 285 (43), pp.32689-94. ⟨10.1074/jbc.M110.147199⟩. ⟨hal-00591660⟩
  • Yves Aubert, Marcel Chassignol, Victoria Roig, Gladys Mbemba, Julien Weiss, et al.. Synthesis and anti-HIV-1 integrase activity of modified dinucleotides. European Journal of Medicinal Chemistry, Elsevier, 2009, 44 (12), pp.5029-5044. ⟨10.1016/j.ejmech.2009.09.007⟩. ⟨hal-00521651⟩
  • Chrystelle Derache, Valérie Labas, Vincent Aucagne, Hervé Meudal, Céline Landon, et al.. Primary Structure and Antibacterial Activity of Chicken Bone Marrow-Derived beta-Defensins. Antimicrobial Agents and Chemotherapy, American Society for Microbiology, 2009, 53 (11), pp.4647-4655. ⟨10.1128/AAC.00301-09⟩. ⟨hal-00522326⟩
  • Thomas Chauvin, Philippe Durand, Michèle Bernier, Hervé Meudal, Bich-Thuy Doan, et al.. Detection of enzymatic activity by PARACEST MRI: a general approach to target a large variety of enzymes. Angewandte Chemie International Edition, Wiley-VCH Verlag, 2008, 47 (23), pp.4370-4372. ⟨10.1002/anie.200800809⟩. ⟨hal-00283242⟩
  • Y. Bilbille, F. Paquet, H. Meudal, M.J. Giraud-Panis, G. Lancelot. NMR studies of telomeric nucleoprotein complexes involving the Myb-like domain of the human telomeric protein TRF2. Comptes Rendus Chimie, Elsevier Masson, 2006, 9 (3-4), pp.452-458. ⟨10.1016/j.crci.2005.06.019⟩. ⟨hal-00088835⟩
  • Nelly Morellet, Hervé Meudal, Serge Bouaziz, Bernard Pierre Roques. Structure of the zinc finger domain encompassing residues 13–51 of the nucleocapsid protein from simian immunodeficiency virus. Biochemical Journal, Portland Press, 2006, 393 (3), pp.725-732. ⟨10.1042/BJ20051203⟩. ⟨hal-02122534⟩
  • Céline Landon, H. Meudal, Nathalie Boulanger, Philippe Bulet, Françoise Vovelle. Solution structures of stomoxyn and spinigerin, two insect antimicrobial peptides with an alpha-helical conformation. Biopolymers, Wiley, 2006, 81 (2), pp.92-103. ⟨10.1002/bip.20370⟩. ⟨hal-00088871⟩
  • Christine Anne, Armand Blommaert, Serge Turcaud, Anne-Sophie Martin, Hervé Meudal, et al.. Thio-derived disulfides as potent inhibitors of botulinum neurotoxin type B: implications for zinc interaction.. Bioorganic & medicinal chemistry, Elsevier, 2003, 11 (21), pp.4655-60. ⟨hal-02122201⟩
  • Christine Anne, Serge Turcaud, Jean Quancard, Franck Teffo, Hervé Meudal, et al.. Development of Potent Inhibitors of Botulinum Neurotoxin Type B. Journal of Medicinal Chemistry, American Chemical Society, 2003, 46 (22), pp.4648-4656. ⟨10.1021/jm0300680⟩. ⟨hal-02122278⟩
  • Nicolas Inguimbert, Pascale Coric, Hervé Poras, Hervé Meudal, Franck Teffot, et al.. Toward an optimal joint recognition of the S1' subsites of endothelin converting enzyme-1 (ECE-1), angiotensin converting enzyme (ACE), and neutral endopeptidase (NEP).. Journal of Medicinal Chemistry, American Chemical Society, 2002, 45 (7), pp.1477-86. ⟨hal-02122182⟩
  • H Chen, F Noble, A Mothé, H Meudal, P Coric, et al.. Phosphinic derivatives as new dual enkephalin-degrading enzyme inhibitors: synthesis, biological properties, and antinociceptive activities.. Journal of Medicinal Chemistry, American Chemical Society, 2000, 43 (7), pp.1398-408. ⟨hal-02122153⟩
  • B Bellier, M. Million, S Danascimento, H. Meudal, S Kellou, et al.. Replacement of glycine with dicarbonyl and related moieties in analogues of the C-terminal pentapeptide of cholecystokinin: CCK(2) agonists displaying a novel binding mode.. Journal of Medicinal Chemistry, American Chemical Society, 2000, 43 (20), pp.3614-23. ⟨hal-02122170⟩
  • S Druillennec, H Meudal, B.P Roques, M.C Fournié-Zaluski. Nucleomimetic strategy for the inhibition of HIV-1 nucleocapsid protein NCp7 activities.. Bioorganic & Medicinal Chemistry Letters, Elsevier, 1999, 9 (4), pp.627-32. ⟨hal-02122144⟩
  • Christelle David, Laurent Bischoff, Hervé Meudal, Aurélie Mothé, Nadia de Mota, et al.. Investigation of Subsite Preferences in Aminopeptidase A (EC 3.4.11.7) Led to the Design of the First Highly Potent and Selective Inhibitors of This Enzyme. Journal of Medicinal Chemistry, American Chemical Society, 1999, 42 (25), pp.5197-5211. ⟨10.1021/jm9903040⟩. ⟨hal-02122148⟩
  • Loïc Martin, Fabrice Cornille, Serge Turcaud, Hervé Meudal, Bernard Roques, et al.. Metallopeptidase Inhibitors of Tetanus Toxin: A Combinatorial Approach. Journal of Medicinal Chemistry, American Chemical Society, 1999, 42 (3), pp.515-525. ⟨10.1021/jm981066w⟩. ⟨hal-02122139⟩
  • B Bellier, S Da Nascimento, H. Meudal, E. Gincel, B.P Roques, et al.. Novel constrained CCK-B dipeptoid antagonists derived from pipecolic acid.. Bioorganic & Medicinal Chemistry Letters, Elsevier, 1998, 8 (11), pp.1419-24. ⟨hal-02122133⟩
  • Laurent Bischoff, Christelle David, Loïc Martin, Hervé Meudal, Bernard-Pierre Roques, et al.. 2,4-Dinitrophenyl 4-Methoxybenzyl Disulfide: A New Efficient Reagent for the Electrophilic Sulfenylation of β-Amino Ester Enolates. Journal of Organic Chemistry, American Chemical Society, 1997, 62 (14), pp.4848-4850. ⟨10.1021/jo9623853⟩. ⟨hal-02122111⟩
  • Bruno Bellier, Isabelle Mccort-Tranchepain, Bertrand Ducos, Sophie Danascimento, Hervé Meudal, et al.. Synthesis and Biological Properties of New Constrained CCK-B Antagonists: Discrimination of Two Affinity States of the CCK-B Receptor on Transfected CHO Cells. Journal of Medicinal Chemistry, American Chemical Society, 1997, 40 (24), pp.3947-3956. ⟨10.1021/jm970439a⟩. ⟨hal-02122116⟩
  • Christelle David, Laurent Bischoff, Hervé Meudal, Catherine Llorens-Cortes, Bernard Pierre Roques, et al.. Characterization and inhibition of aminopeptidase A by α-mercapto-β-amino acyl dipeptides. Letters in Peptide Science, Springer Verlag, 1997, 4 (4/6), pp.411-414. ⟨10.1023/A:1008894115205⟩. ⟨hal-02122127⟩
  • Wang-Qing Liu, François Carreaux, Hervé Meudal, Bernard Roques, Christiane Garbay-Jaureguiberry. Synthesis of constrained 4-(phosphonomethyl)phenylalanine derivatives as hydrolytically stable analogs of O-phosphotyrosine. Tetrahedron, Elsevier, 1996, 52 (12), pp.4411-4422. ⟨10.1016/0040-4020(96)00085-3⟩. ⟨hal-02122054⟩
  • Marie-Claude Fournie-Zaluski, Pascale Coric, Vincent Théry, Walter Gonzalez, Hervé Meudal, et al.. Design of Orally Active Dual Inhibitors of Neutral Endopeptidase and Angiotensin-Converting Enzyme with Long Duration of Action. Journal of Medicinal Chemistry, American Chemical Society, 1996, 39 (13), pp.2594-2608. ⟨10.1021/jm950783c⟩. ⟨hal-02122108⟩
  • Pascale Coric, Serge Turcaud, Hervé Meudal, Bernard Pierre Roques, Marie-Claude Fournie-Zaluski. Optimal Recognition of Neutral Endopeptidase and Angiotensin-Converting Enzyme Active Sites by Mercaptoacyldipeptides as a Means To Design Potent Dual Inhibitors. Journal of Medicinal Chemistry, American Chemical Society, 1996, 39 (6), pp.1210-1219. ⟨10.1021/jm950590p⟩. ⟨hal-02122055⟩
  • C Guis, L Bruetschy, H. Meudal, B. Roques, G Gacel. Investigation of the structural parameters involved in the delta-opioid selectivity of several families of opioid peptides.. International Journal of Peptide and Protein Research, 1993, 41 (6), pp.576-86. ⟨hal-02122053⟩

PILLER Véronique

email : veronique.piller@cnrs-orleans.fr

Phone :+33 2.38.25.76.46 ou 78.05

Office A211

Researcher within the thematic group “Synthetic protein and bioorthogonal chemistry

 



19 documents

Article dans une revue

  • David Montoir, Mehdi Amoura, Zine El Abidine Ababsa, T. Vishwanatha, Expédite Yen-Pon, et al.. Synthesis of aryl-thioglycopeptides through chemoselective Pd-mediated conjugation. Chemical Science , The Royal Society of Chemistry, 2018, 9 (46), pp.8753-8759. ⟨hal-01966170⟩
  • Aline Mongis, Friedrich Piller, Véronique Piller. Coupling of Immunostimulants to Live Cells through Metabolic Glycoengineering and Bioorthogonal Click Chemistry. Bioconjugate Chemistry, American Chemical Society, 2017, 28 (4), pp.1151 - 1165. ⟨10.1021/acs.bioconjchem.7b00042⟩. ⟨hal-01618670⟩
  • Mathieu Galibert, Véronique Piller, Friedrich Piller, Vincent Aucagne, Agnès F. Delmas. Combining triazole ligation and enzymatic glycosylation on solid phase simplifies the synthesis of very long glycoprotein analogues. Chemical Science , The Royal Society of Chemistry, 2015, 6 (6), pp.3617-3623. ⟨10.1039/C5SC00773A⟩. ⟨hal-01178852⟩
  • Kelly N. Chuh, Balyn W. Zaro, Friedrich Piller, Véronique Piller, Matthew R. Pratt. Changes in Metabolic Chemical Reporter Structure Yield a Selective Probe of O-GlcNAc Modification. Journal of the American Chemical Society, American Chemical Society, 2014, 136 (35), pp.12283-12295. ⟨10.1021/ja504063c⟩. ⟨hal-01178483⟩
  • Sabrina Pouilly, Vanessa Bourgeaux, Friedrich Piller, Véronique Piller. Evaluation of analogues of GalNAc as substrates for enzymes of the mammalian GalNAc salvage pathway.. ACS Chemical Biology, American Chemical Society, 2012, 7 (4), pp.753-60. ⟨10.1021/cb200511t⟩. ⟨hal-00726252⟩
  • Sabrina Pouilly, Véronique Piller, Friedrich Piller. Metabolic glycoengineering through the mammalian GalNAc salvage pathway.. FEBS Journal, Wiley, 2012, 279 (4), pp.586-98. ⟨10.1111/j.1742-4658.2011.08448.x⟩. ⟨hal-00726255⟩
  • Alicja Solatycka, Tomasz Owczarek, Friedrich Piller, Véronique Piller, Bartosz Pula, et al.. MUC1 in human and murine mammary carcinoma cells decreases the expression of core 2 β1,6-N-acetylglucosaminyltransferase and β-galactoside α2,3-sialyltransferase. Glycobiology, Oxford University Press (OUP), 2012, 22 (8), pp.1042-54. ⟨10.1093/glycob/cws075⟩. ⟨hal-00726281⟩
  • Vanessa Bourgeaux, Martine Cadene, Friedrich Piller, Véronique Piller. Efficient enzymatic glycosylation of peptides and oligosaccharides from GalNAc and UTP. ChemBioChem, Wiley-VCH Verlag, 2007, 8 (1), pp.37-40. ⟨hal-00282379⟩
  • Vanessa Bourgeaux, Martine Cadène, Friedrich Piller, Véronique Piller. Efficient Enzymatic Glycosylation of Peptides and Oligosaccharides from GalNAc and UTP. ChemBioChem, Wiley-VCH Verlag, 2007, 8 (1), pp.37-40. ⟨10.1002/cbic.200600369⟩. ⟨hal-00158348⟩
  • Gaëlle-Anne Cremer, Nicole Bureaud, Véronique Piller, Horst Kunz, Friedrich Piller, et al.. Synthesis and biological evaluation of a multiantigenic Tn/TF-containing glycopeptide mimic of the tumor-related MUC1 glycoprotein. ChemMedChem, Wiley-VCH Verlag, 2006, 1 (9), pp.965-968. ⟨10.1002/cmdc.200600104⟩. ⟨hal-00168620⟩
  • Cremer G.A., N. Bureaud, V. Piller, H. Kunz, F. Piller, et al.. Synthesis and biological evaluation of a multiantigenic Tn/TF-containing glycopeptide mimic of the tumor-related MUC1 glycoprotein. ChemMedChem, Wiley-VCH Verlag, 2006, 1, pp.965-968. ⟨10.1002/cmdc.200600104⟩. ⟨hal-00094558⟩
  • Teresa Freire, Richard Lo-Man, Friedrich Piller, Véronique Piller, Claude Leclerc, et al.. Enzymatic large-scale synthesis of MUC6-Tn glycoconjugates for antitumor vaccination.. Glycobiology, Oxford University Press (OUP), 2006, 16 (5), pp.390-401. ⟨10.1093/glycob/cwj082⟩. ⟨pasteur-00166623⟩
  • V. Bourgeaux, F. Piller, V. Piller. Two-step enzymatic synthesis of UDP-N-acetylgalactosamine. Bioorganic and Medicinal Chemistry, Elsevier, 2005, 15, pp.5459-5462. ⟨hal-00088511⟩
  • I. Martinez-Duncker, T. DuprÉ, V. Piller, F. Piller, J.J. Candelier, et al.. Genetic complementation reveals a novel human congenital disorder of glycosylation of type II, due to inactivation of the Golgi CMP-sialic acid transporter. Blood, American Society of Hematology, 2005, 105, pp.2671-2676. ⟨hal-00088624⟩
  • E. Mennesson, P. Erbacher, V. Piller, C. Kieda, P. Midoux, et al.. Transfection efficiency and uptake process of polyplexes in human lung endothetial cells: a comparative study in non-polarized and polarized cells. The Journal of Gene Medicine, Wiley, 2005, 7, pp.729-738. ⟨hal-00088642⟩
  • G.A. Cremer, N. Bureaud, D. Lelièvre, V. Piller, F. Piller, et al.. Synthesis of branched oxime-linked peptide mimetics of the MUC1 containing a universal T-helper epitope. Chemistry - A European Journal, Wiley-VCH Verlag, 2004, 10 (24), pp.6353-6360. ⟨10.1002/chem.200400780⟩. ⟨hal-00112972⟩
  • M. Dalziel, F. Dall'Olio, A. Mungul, V. Piller, F. Piller. Ras oncogene induces β-galactoside α2,6-sialytransferase (ST6Gal I) via a RalGEF-mediated signal to its housekeeping promoter. European Journal of Biochemistry, Wiley, 2004, 271 (18), pp.3623-3634. ⟨10.1111/j.1432-1033.2004.04284.x⟩. ⟨hal-00112974⟩
  • S. Duclos, P. Da Silva, F. Vovelle, F. Piller, V. Piller. Characterization of the UDP-N- acetylgalactosamine binding domain of bovine polypeptide α N-acetylgalactosaminyltranferase T1. Protein Engineering, Design and Selection, Oxford University Press (OUP), 2004, 17 (8), pp.635-646. ⟨10.1093/protein/gzh075⟩. ⟨hal-00112977⟩
  • V. Carrière, V. Piller, Alain Legrand, M. Monsigny, A. Roche. The sugar binding activity of MR60, a mannose-specific shuttling lectin, requires a dimeric state. Glycobiology, Oxford University Press (OUP), 1999, 9 (10), pp.995-1002. ⟨10.1093/glycob/9.10.995⟩. ⟨hal-02138032⟩

GAUDON Virginie

email : virginie.gaudon@cnrs-orleans.fr

Phone : +33 2.38.25.55.64

Office D210

Technician biologist within the thematic group “DNA repair: structure, fonction and dynamic

 



3 documents

Article dans une revue

  • Sascha Trapp, Denis Soubieux, Alexandra Lidove, Evelyne Esnault, Adrien Lion, et al.. Major contribution of the RNA-binding domain of NS1 in the pathogenicity and replication potential of an avian H7N1 influenza virus in chickens. Virology Journal, BioMed Central, 2018, 15 (1). ⟨hal-01966420⟩
  • R. Le Meur, F. Culard, V. Nadan, S. Goffinont, F. Coste, et al.. The nucleoid-associated protein HU enhances 8-oxoguanine base excision by the formamidopyrimidine-DNA glycosylase. Biochemical Journal, Portland Press, 2015, 471 (1), pp.13-23. ⟨10.1042/BJ20150387⟩. ⟨hal-01216639⟩
  • Norbert Garnier, Karine Loth, Franck Coste, Rafal Augustyniak, Virginie Nadan, et al.. An alternative flexible conformation of the E. coli HU beta(2) protein: structural, dynamics, and functional aspects. European Biophysics Journal, Springer Verlag (Germany), 2011, 40 (2), pp.117-129. ⟨10.1007/s00249-010-0630-y⟩. ⟨hal-00602370⟩