Cell biology, Molecular Targets and Innovative Therapies

The team gathers researchers from cell and molecular biology, biochemistry, physico-chemistry and pharmacology disciplines. We are conducting projects based on a crosstalk between basic investigations and translational researches.

Team leaders: Chantal PICHON & Hélène BÉNÉDETTI

Advanced molecular approaches of biochemistry, cell and molecular biology are exploited in conjunction with cell and animal models to decipher molecular biological processes occurring under physiological or pathological conditions.

The main focus of projects is the development of novel therapeutic strategies through improved knowledge of cellular processes including gene expression (RNA biology) and signalling cascades that allow us to identify biomarkers and new targets of specific diseases. Gained data from these fundamental studies will be exploited in turn to build innovative therapies which encompass the design and vectorization of therapeutic agents.

Our main interests are cancer, neurodegenerative diseases and in skin biology.

You will find here the main techniques and the main equipment used.

The research programs are reorganized in 5 main themes:

Innovative therapies and nanomedicine

Group leaders: Patrick MIDOUX and Jean-Marc MALINGE

RNA biology and RNA therapeutics

Group leaders: Chantal PICHON and Rachid RAHMOUNI

Normal and pathological apoptosis and autophagy

Cell signalling

Group leaders: Hélène BÉNÉDETTI and Alain LEGRAND

Skin biology

Group leaders: Catherine GRILLON and Chantal PICHON

Pharmacological targets and biomarkers

Cell microenvironment and receptor pharmacology