Thérapies innovantes et nanomédecine

Responsables : Chantal PICHON et Patrick BARIL

Descriptif du travail de recherche

Nos activités de recherche englobent le développement et l'optimisation des acides nucléiques thérapeutiques. Nous optimisons leurs formulations, leur délivrance et ciblage selon les voies d'administration. Il s'agit d'un domaine de recherche multidisciplinaire nécessitant différentes disciplines comme la chimie, la physico-chimie, la biologie moléculaire et cellulaire.

Concernant le transfert de gène, nous avons maintenant identifié plusieurs attributs pour concevoir un virus artificiel. Pour cela, la bio-ingénierie de l'ADN plasmidique est développée en couplant des signaux intracellulaires spécifiques en tant que transport cytosolique à médiation peptidique et des séquences d'ADN pour l'importation nucléaire. Nous explorons également l'approche de co-délivrance des siRNA, des anti-microARN et / ou des leurres d'ADN contre les oncogènes dans le mélanome et le cancer de sein triple négatif. Les leurres d'ADN sont basés sur de petits acides nucléiques bio-conçus pour le ciblage cellulaire et intracellulaire.

 

Notre expertise de longue date dans le transfert d'ADN plasmidique par des vecteurs synthétiques est exploitée pour optimiser la délivrance d'autres types d'acides nucléiques, tels que les oligonucléotides, les leurres d'ADN, les ARN interférants, les microARNs et les ARNms. Notre formulation originale appelée « Lipopolyplexe » est un nanoparticule hybride de liposomes et de polymère complexant l’ARNm (LPR). Celui-ci peut être pourvu de motif saccharidique comme le trimannose pour le ciblage des cellules dendritiques. Un LPR comprenant des ARNm codant pour des antigènes tumoraux s'est avéré être très efficace comme vaccin contre le cancer. Nous souhaitons renforcer cet axe en améliorant la livraison in vivo pour les essais précliniques et, espérons-le, les essais cliniques.

TriMN-LPR formulation comprises mRNA of tumor specific antigen/histidinylated polymer and tri-mannose-bearing liposomTriMN-LPR formulation comprises mRNA of tumor specific antigen/histidinylated polymer and tri-mannose-bearing liposomes. Van der Jeught, K., et al., ACS nano, 2018, 12: 9815-9829.

L'équipe travaille également sur la sonoporation basée sur les ultrasons (US) et les microbulles (MB) pour délivrer des acides nucléiques et des médicaments in vitro et in vivo. Nous avons réalisé une étude pionnière révélant la traduction intracellulaire de microbulles lors d'une administration efficace de médicaments par sonoporation, bien reconnue dans le domaine. Développements actuels du MB cationique original avec une taille plus petite et une grande capacité d'encapsulation. La principale application est la délivrance d'ADN plasmidique / ARNm pour restaurer l'expression de gènes mutés pour les maladies génétiques et le glioblastome. Ce projet est soutenu par C’valo, un dispositif  d’investissements en région Centre-Val de Loire soutenant le développement économique de son territoire en transformant les inventions des chercheurs académiques en innovation.

ARN thérapeutiques

Ces dernières années, les ARN messagers sont apparus comme de nouveaux biomédicaments. Aujourd'hui, les ARNm sont produits par transcription in vitro. Malgré l'optimisation de leur production, celle-ci reste coûteuse car elle nécessite de nombreux réactifs et étapes. La recherche d'une autre option permettant une production en grande échelle à bas coût pourrait être avantageuse pour le développement clinique. C'est le défi que nous avons relevé en concevant une usine de cellules à base de levure pour la production d'ARNm. Cet eucaryote unicellulaire, considéré comme sûr pour la bioproduction, est extrêmement utile dans le domaine de l'ARN car il possède un métabolisme de l'ARN transposable aux eucaryotes supérieurs. Une vaste gamme d'outils génétiques, de méthodes moléculaires et biochimiques sont disponibles pour les études sur les levures. Nous avons génétiquement modifié des cellules de levure pour produire à la demande de l'ARNm d'intérêt et pour les cibler dans un compartiment spécifique facile à purifier. Nous avons réussi à générer des mutants de levure transcriptionnels qui expriment de l'ARNm hétérologue mature et intact, ciblé et confiné à l'intérieur de rétrosomes. L'ARNm bio produit est coiffé, polyadénylé et présente des nucléosides modifiés. Il est également efficacement exprimé in cellulo et in vivo. À notre connaissance, cette étude est la première preuve de concept indiquant la faisabilité de la bioproduction d'ARNm. (Pigeon et al., PCT/EP 2018/025066)

 

Compétences / savoir-faire

  • Synthèse et chimie fine de l’ADN
  • Vectorisation d’acides nucléiques
  • Endocytose et trafic intracellulaire
  • Microscopie confocale
  • Cytométrie en flux
  • Transfection
  • Expérimentation animale
  • Imagerie fonctionnelle in vivo

Principales publications :

Van der Jeught K., De Koker S., Bialkowski L., Heirman C., Tjok Joe P., Perche F., Maenhout S., Bevers S., Broos K., Deswarte K., Malard V., Hammad H., Baril P., Benvegnu T., Jaffrès P.-A., Kooijmans S.A.A., Schiffelers R., Lienenklaus S., Midoux P., Pichon C.*, Breckpot K.*, Thielemans K.* (2018) Dendritic Cell Targeting. mRNA Lipopolyplexes Combine Strong Antitumor T-Cell Immunity with Improved Inflammatory safety. ACS Nano. 12 (10) 9815-9829. doi:10.1021/acsnano.8b00966 *Co-last author and $corresponding author (IF:13.7).

Manta S., Renault G., Delalande A., Couture O., Lagoutte I., Seguin J., Lager F., Houzé P., Midoux P., Bessodes M., Scherman D., Bureau M.-F., Marie C., Pichon C.*$, Mignet N.* (2017) Cationic microbubbles and antibiotic-free miniplasmid for sustained ultrasound-mediated transgene expression in liver. J Control Release. 262, 170-181. doi: 10.1016/j.jconrel.2017.07.015 *Co-last author and $corresponding author (IF:7.7).

Delalande A., Gosselin M.-P., Suwalski A., Guilmain W., Leduc C., Berchel M., Jaffrès P.-A., Baril P., Midoux P., Pichon C. (2015) Enhanced Achilles tendon healing by fibromodulin gene transfer. Nanomedicine. Nanotechnology biology and medicine. 11 (7) 1735-1744. doi: 10.1016/j.nano.2015.05.004 (IF: 7.78).

Pigeon L., Gonçalves C., Gosset D., Pichon C., Midoux P. (2013) An E3-14.7K Peptide that Promotes MicrotubulesMediated Transport of Plasmid DNA Increases Polyplexes Transfection Efficiency. Small. 9 (22) 3845-3851.  doi:10.1002/smll.201300217 (IF: 7.514).

Delalande A., Bouakaz A., Renault G., Tabareau F., Kotopoulis S., Midoux P., Arbeille B., Uzbekov R., Chakravarti S., Postema M., Pichon C. (2011) Ultrasound and microbubble-assisted gene delivery in Achilles tendons: Long lasting gene expression and restoration of fibromodulin KO phenotype. J Control Release. 156 (2) 223-230. doi:10.1016/j.jconrel.2011.08.020 (IF: 7.7).

Breuzard G., Tertil M., Goncalves C., Cheradame H., Geguan P., Pichon C.*, Midoux P.* (2008) Nuclear delivery of NFkappaB-assisted DNA/polymer complexes: plasmid DNA quantitation by confocal laser scanning microscopy and evidence of nuclear polyplexes by FRET imaging. Nucleic Acids Res. 36 (12) e71. doi:10.1093/nar/gkn287 (* co last authors) (IF6.8).

 

 

 

 

 



339 documents

Article dans une revue

  • V. Vijayarangan, A. Delalande, S. Dozias, J.-M. Pouvesle, E. Robert, et al.. New insights on molecular internalization and drug delivery following plasma jet exposures. International Journal of Pharmaceutics, Elsevier, 2020, 589, pp.119874. ⟨10.1016/j.ijpharm.2020.119874⟩. ⟨hal-03025365⟩
  • Vinodini Vijayarangan, A. Delalande, S. Dozias, Jean-Michel Pouvesle, E. Robert, et al.. New insights on molecular internalization and drug delivery following plasma jet exposures. International Journal of Pharmaceutics, Elsevier, 2020, 589, pp.119874. ⟨10.1016/j.ijpharm.2020.119874⟩. ⟨hal-03043274⟩
  • Bazoly Rasolonjatovo, Nicolas Illy, Véronique Bennevault, Jérôme Mathé, Patrick Midoux, et al.. Temperature‐Sensitive Amphiphilic Non‐Ionic Triblock Copolymers for Enhanced In Vivo Skeletal Muscle Transfection. Macromolecular Bioscience, Wiley-VCH Verlag, In press, 20 (3), pp.1900276. ⟨10.1002/mabi.201900276⟩. ⟨hal-02451051⟩
  • Natalia Kozlova, Chantal Pichon, A. Rachid Rahmouni. mRNA with Mammalian Codon Bias Accumulates in Yeast Mutants with Constitutive Stress Granules. International Journal of Molecular Sciences, MDPI, 2020, 21 (4), pp.1234. ⟨10.3390/ijms21041234⟩. ⟨hal-02524994⟩
  • Haifei Gao, Cristine Goncalves, Téo Gallego, Marc Francois-Heude, Virginie Malard, et al.. Comparative binding and uptake of liposomes decorated with mannose oligosaccharides by cells expressing the mannose receptor or DC-SIGN. Carbohydrate Research, Elsevier, 2020, 487, pp.107877. ⟨10.1016/j.carres.2019.107877⟩. ⟨hal-02522179⟩
  • Viorel Simion, Elodie Henriet, Viktorija Juric, Ruth Aquino, Claire Loussouarn, et al.. Intracellular trafficking and functional monitoring of miRNA delivery in glioblastoma using lipopolyplexes and the miRNA-ON RILES reporter system. Journal of Controlled Release, Elsevier, 2020, 327, pp.429-443. ⟨10.1016/j.jconrel.2020.08.028⟩. ⟨hal-02959393⟩
  • Mohamed Barkallah, Ahlem Ben Slima, Fatma Elleuch, Imen Fendri, Chantal Pichon, et al.. Protective Role of Spirulina platensis against Bifenthrin-Induced Reprotoxicity in Adult Male Mice by Reversing Expression of Altered Histological, Biochemical, and Molecular Markers Including MicroRNAs. Biomolecules, MDPI, 2020, 10 (5), pp.753. ⟨10.3390/biom10050753⟩. ⟨hal-02901693⟩
  • Fatma Elleuch, Patrick Baril, Mohamed Barkallah, Federico Perche, Slim Abdelkafi, et al.. Deciphering the Biological Activities of Dunaliella sp. Aqueous Extract from Stressed Conditions on Breast Cancer: from in Vitro to in Vivo Investigations. International Journal of Molecular Sciences, MDPI, 2020, 21 (5), pp.1719. ⟨10.3390/ijms21051719⟩. ⟨hal-02553031⟩
  • Maximilien Clabaut, Amine Boukerb, Pierre-Jean Racine, Chantal Pichon, Coralie Kremser, et al.. Draft Genome Sequence of Lactobacillus crispatus CIP 104459, Isolated from a Vaginal Swab. Microbiology Resource Announcements, American Society for Microbiology, 2020, 9 (2), ⟨10.1128/MRA.01373-19⟩. ⟨hal-02535839⟩
  • Pinpin Wang, Delphine Logeart-Avramoglou, Hervé Petite, Cristine Gonçalves, Patrick Midoux, et al.. Co-delivery of NS1 and BMP2 mRNAs to murine pluripotent stem cells leads to enhanced BMP-2 expression and osteogenic differentiation. Acta Biomaterialia, Elsevier, 2020, 108, pp.337-346. ⟨10.1016/j.actbio.2020.03.045⟩. ⟨hal-02553030⟩
  • Satoshi Uchida, Federico Perche, Chantal Pichon, Horacio Cabral. Nanomedicine-Based Approaches for mRNA Delivery. Molecular Pharmaceutics, American Chemical Society, 2020, 17 (10), pp.3654 - 3684. ⟨10.1021/acs.molpharmaceut.0c00618⟩. ⟨hal-02995814⟩
  • Ambre Dauba, Anthony Delalande, Hermes Kamimura, Allegra Conti, Benoit Larrat, et al.. Recent Advances on Ultrasound Contrast Agents for Blood-Brain Barrier Opening with Focused Ultrasound. Pharmaceutics, MDPI, 2020, 12, ⟨10.3390/pharmaceutics12111125⟩. ⟨hal-03024904⟩
  • Hao Li, Carolina Gascó, Anthony Delalande, Clarence Charnay, Laurence Raehm, et al.. Periodic Mesoporous Organosilica Nanoparticles with BOC Group, towards HIFU Responsive Agents. Molecules, MDPI, 2020, 25 (4), pp.974. ⟨10.3390/molecules25040974⟩. ⟨hal-02544155⟩
  • Nhi Thao Le, David da Silva, Cyril Colas, Éric Darrouzet, Patrick Baril, et al.. Asian hornet Vespa velutina nigrithorax venom: Evaluation and identification of the bioactive compound responsible for human keratinocyte protection against oxidative stress. Toxicon, Elsevier, 2020, 176, pp.1-9. ⟨10.1016/j.toxicon.2020.01.001⟩. ⟨hal-02794316⟩
  • Thao Nhi Le, David da Silva, Cyril Colas, Éric Darrouzet, Patrick Baril, et al.. Development of an LC-MS multivariate nontargeted methodology for differential analysis of the peptide profile of Asian hornet venom (Vespa velutina nigrithorax): application to the investigation of the impact of collection period variation. Analytical and Bioanalytical Chemistry, Springer Verlag, 2020, 412 (6), pp.1419-1430. ⟨10.1007/s00216-019-02372-2⟩. ⟨hal-02794337⟩
  • Laetitia Plet, Gwendoline Delecourt, Mohamed Hanafi, Nadège Pantoustier, Gaelle Pembouong, et al.. Controlled star poly(2-oxazoline)s: Synthesis, characterization. European Polymer Journal, Elsevier, 2020, 122, pp.109323. ⟨10.1016/j.eurpolymj.2019.109323⟩. ⟨hal-02541990⟩
  • Florence Abdallah, Chantal Pichon. Evidence on the direct correlation between miR‐31 and IL ‐22 axis in IMQ ‐induced psoriasis. Experimental Dermatology, Wiley, 2019, 28 (11), pp.1336-1340. ⟨10.1111/exd.14001⟩. ⟨hal-02521769⟩
  • Emmanuelle Villedieu-Percheron, Véronique Ferreira, Joana Filomena Campos, Emilie Destandau, Chantal Pichon, et al.. Quantitative Determination of Andrographolide and Related Compounds in Andrographis paniculata Extracts and Biological Evaluation of Their Anti-Inflammatory Activity. Foods, MDPI, 2019, 8 (12), pp.683. ⟨10.3390/foods8120683⟩. ⟨hal-02521988⟩
  • Maximilien Clabaut, Amine Boukerb, Pierre-Jean Racine, Chantal Pichon, Coralie Kremser, et al.. Draft Genome Sequence of Lactobacillus crispatus Strain V4, Isolated from a Vaginal Swab from a Young Healthy Nonmenopausal Woman. Microbiology Resource Announcements, American Society for Microbiology, 2019, 8 (38), pp.e00856-19. ⟨10.1128/MRA.00856-19⟩. ⟨hal-02309567⟩
  • Federico Perche, Tony Le Gall, Tristan Montier, Chantal Pichon, Jean-Marc Malinge. Cardiolipin-Based Lipopolyplex Platform for the Delivery of Diverse Nucleic Acids into Gram-Negative Bacteria. Pharmaceuticals, MDPI, 2019, 12 (2), pp.81. ⟨10.3390/ph12020081⟩. ⟨hal-02995618⟩
  • Federico Perche. Stimuli-Sensitive Cell Penetrating Peptide-Modified Nanocarriers. Processes, MDPI, 2019, 7 (10), pp.727. ⟨10.3390/pr7100727⟩. ⟨hal-02321861⟩
  • Nathalie Mignet, Corinne Marie, Anthony Delalande, Simona Manta, Michel-Francis Bureau, et al.. Microbubbles for Nucleic Acid Delivery in Liver Using Mild Sonoporation. Methods in Molecular Biology, Humana Press/Springer Imprint, 2019, 1943, pp.377-387. ⟨10.1007/978-1-4939-9092-4_25⟩. ⟨hal-02521922⟩
  • Federico Perche, Rudy Clemençon, Kai Schulze, Thomas Ebensen, Carlos Guzman, et al.. Neutral Lipopolyplexes for In Vivo Delivery of Conventional and Replicative RNA Vaccine. Molecular Therapy - Nucleic Acids, Nature Publishing Group, 2019, 17, pp.767-775. ⟨10.1016/j.omtn.2019.07.014⟩. ⟨hal-02321815⟩
  • Arnaud Chaix, Eduardo Cueto-Diaz, Anthony Delalande, Nikola Knezevic, Patrick Midoux, et al.. Amino-acid functionalized porous silicon nanoparticles for the delivery of pDNA. RSC Advances, Royal Society of Chemistry, 2019, 9 (55), pp.31895-31899. ⟨10.1039/c9ra05461h⟩. ⟨hal-02338857⟩
  • Federico Perche, Tony Le Gall, Tristan Montier, Chantal Pichon, Jean-Marc Malinge. Cardiolipin-Based Lipopolyplex Platform for the Delivery of Diverse Nucleic Acids into Gram-Negative Bacteria. Pharmaceuticals, MDPI, 2019, 12 (2), pp.81. ⟨10.3390/ph12020081⟩. ⟨hal-02172973⟩
  • Yu Yi, Hyun Jin Kim, Meng Zheng, Peng Mi, Mitsuru Naito, et al.. Glucose-linked sub-50-nm unimer polyion complex-assembled gold nanoparticles for targeted siRNA delivery to glucose transporter 1-overexpressing breast cancer stem-like cells. Journal of Controlled Release, Elsevier, 2019, 295, pp.268 - 277. ⟨10.1016/j.jconrel.2019.01.006⟩. ⟨hal-02995629⟩
  • Jean-Pierre Gomez, Guillaume Tresset, Chantal Pichon, Patrick Midoux. Improved histidinylated lPEI polyplexes for skeletal muscle cells transfection. International Journal of Pharmaceutics, Elsevier, 2019, 559, pp.58-67. ⟨10.1016/j.ijpharm.2019.01.003⟩. ⟨hal-02067297⟩
  • Florence Abdallah, Gaêl Lecellier, Phila Raharivelomanana, Chantal Pichon. R. nukuhivensis acts by reinforcing skin barrier function, boosting skin immunity and by inhibiting IL-22 induced keratinocyte hyperproliferation. Scientific Reports, Nature Publishing Group, 2019, 9 (4132), ⟨10.1038/s41598-019-39831-w⟩. ⟨hal-02521734⟩
  • Pinpin Wang, Federico Perche, Delphine Logeart-Avramoglou, Chantal Pichon. RNA-based therapy for osteogenesis. International Journal of Pharmaceutics, Elsevier, 2019, 569, pp.118594. ⟨10.1016/j.ijpharm.2019.118594⟩. ⟨hal-02995602⟩
  • Kevin van der Jeught, Stefaan de Koker, Lukasz Bialkowski, Carlo Heirman, Patrick Tjok Joe, et al.. Dendritic Cell Targeting mRNA Lipopolyplexes Combine Strong Antitumor T-Cell Immunity with Improved Inflammatory Safety. ACS Nano, American Chemical Society, 2018, 12 (10), pp.9815 - 9829. ⟨10.1021/acsnano.8b00966⟩. ⟨hal-02995709⟩
  • Vinodini Vijayarangan, Anthony Delalande, Sébastien Dozias, Jean-Michel Pouvesle, Chantal Pichon, et al.. Cold Atmospheric Plasma Parameters Investigation for Efficient Drug Delivery in HeLa Cells. IEEE Transactions on Radiation and Plasma Medical Sciences, IEEE, 2018, 2 (2), pp.109-115. ⟨hal-01940672⟩
  • Mathilde Dréan, Antoine Debuigne, Christine Jérôme, Cristine Gonçalves, Patrick Midoux, et al.. Poly( N -methylvinylamine)-Based Copolymers for Improved Gene Transfection. Macromolecular Bioscience, Wiley-VCH Verlag, 2018, 18 (4), pp.1700353. ⟨hal-01966107⟩
  • Shubaash Anthiya, Audrey Griveau, Claire Loussouarn, Patrick Baril, Martin Garnett, et al.. MicroRNA-based Drugs for Brain Tumours. Trends in Cancer, Cell Press, 2018, 4 (3), pp.222-238. ⟨10.1016/j.trecan.2017.12.008⟩. ⟨inserm-01691531⟩
  • Philippe Michaud, Mouna Dammak, Bilel Hadrich, Mohamed Barkallah, Faiez Hentati, et al.. Modelling Tetraselmis sp. growth-kinetics and optimizing bioactive-compound production through environmental conditions. Bioresource Technology, Elsevier, 2018, 249, pp.510 - 518. ⟨10.1016/j.biortech.2017.10.028⟩. ⟨hal-01657730⟩
  • Mouna Dammak, Bilel Hadrich, Mohamed Barkallah, Faiez Hentati, Hajer Ben Hlima, et al.. Modelling Tetraselmis sp. growth-kinetics and optimizing bioactive-compound production through environmental conditions. Bioresource Technology, Elsevier, 2018, 249, pp.510-518. ⟨10.1016/j.biortech.2017.10.028⟩. ⟨hal-02520703⟩
  • Phila Raharivelomanana, Jean-Luc Ansel, Elise Lupo, Lily Mijouin, Samuel Guillot, et al.. Tamanu oil and skin active properties: from traditional to modern cosmetic uses. Ocl-Oilseeds and Fats Crops and Lipids, 2018. ⟨hal-01966367⟩
  • Yohann Corvis, Simona Manta, Caroline Thébault, Olivier Couture, Hélène Dhotel, et al.. Novel Perfluorinated Triblock Amphiphilic Copolymers for Lipid-Shelled Microbubble Stabilization. Langmuir, American Chemical Society, 2018, 34 (33), pp.9744-9753. ⟨10.1021/acs.langmuir.8b01668⟩. ⟨hal-02123140⟩
  • Kevin van der Jeught, Stefaan de Koker, Lukasz Bialkowski, Carlo Heirman, Patrick Tjok Joe, et al.. Dendritic Cell Targeting mRNA Lipopolyplexes Combine Strong Antitumor T-Cell Immunity with Improved Inflammatory Safety. ACS Nano, American Chemical Society, 2018, 12 (10), pp.9815-9829. ⟨10.1021/acsnano.8b00966⟩. ⟨hal-01889829⟩
  • A. Le Moignic, V. Malard, T. Benvegnu, L. Lemiègre, Mathieu Berchel, et al.. Preclinical evaluation of mRNA trimannosylated lipopolyplexes as therapeutic cancer vaccines targeting dendritic cells. Journal of Controlled Release, Elsevier, 2018, 278, pp.110 - 121. ⟨10.1016/j.jconrel.2018.03.035⟩. ⟨hal-01774851⟩
  • Sarwar Beg, Mahfoozur Rahman, Atul Jain, Sumant Saini, Patrick Midoux, et al.. Nanoporous metal organic frameworks as hybrid polymer–metal composites for drug delivery and biomedical applications. Drug Discovery Today Biosilico, Elsevier, 2017, 22 (4), pp.625-637. ⟨10.1016/j.drudis.2016.10.001⟩. ⟨hal-02068701⟩
  • Vítor Gaspar, Carla Cruz, João A. Queiroz, Chantal Pichon, Ilídio J. Correia, et al.. Highly selective capture of minicircle DNA biopharmaceuticals by a novel zinc-histidine peptide conjugate. Separation and Purification Technology, Elsevier, 2017, 174 (26), pp.417 - 424. ⟨10.1016/j.seppur.2016.10.054⟩. ⟨hal-01618255⟩
  • Jean-Pierre Gomez, Cristine Gonçalves, Chantal Pichon, Patrick Midoux. Effect of IL-1β, TNF-α and IGF-1 on trans-endothelial passage of synthetic vectors through an in vitro vascular endothelial barrier of striated muscle. Gene Therapy, Nature Publishing Group, 2017, 24 (7), pp.416 - 424. ⟨10.1038/gt.2017.40⟩. ⟨hal-01618260⟩
  • Patrick Midoux, Lucie Pigeon, Cristine Goncalves, Chantal Pichon. Peptides mediating DNA transport on microtubules and their impact on non-viral gene transfer efficiency. Bioscience Reports, Portland Press, 2017, 37 (5), pp.BSR20170995. ⟨10.1042/BSR20170995⟩. ⟨hal-02068759⟩
  • Javed Ahmad, Madhur Singhal, Saima Amin, Md. Rizwanullah, Sohail Akhter, et al.. Bile Salt Stabilized Vesicles (Bilosomes): A Novel Nano-Pharmaceutical Design for Oral Delivery of Proteins and Peptides. Current Pharmaceutical Design, Bentham Science Publishers, 2017, 23 (11), pp.1575 - 1588. ⟨10.2174/1381612823666170124111142⟩. ⟨hal-01656515⟩
  • Thomas Démoulins, Pavlos C Englezou, Panagiota Milona, Nicola Ruggli, Nicola Tirelli, et al.. Self-Replicating RNA Vaccine Delivery to Dendritic Cells.. Methods in Molecular Biology, Humana Press/Springer Imprint, 2017, pp.37-75. ⟨10.1007/978-1-4939-6481-9_3⟩. ⟨hal-01656568⟩
  • Samuel Guillot, Fabienne Meducin, Kristina Poljak, Virginie Malard, Alexandra Foucault-Collet, et al.. Nanostructured monolinolein miniemulsions as delivery systems: Role of the internal mesophase on cytotoxicity and cell internalization. International Journal of Pharmaceutics, Elsevier, 2017, 523 (1), pp.142 - 150. ⟨10.1016/j.ijpharm.2017.03.012⟩. ⟨hal-01656547⟩
  • Florence Abdallah, Lily Mijouin, Chantal Pichon. Skin Immune Landscape: Inside and Outside the Organism. Mediators of Inflammation, Hindawi Publishing Corporation, 2017, 2017, pp.1 - 17. ⟨10.1155/2017/5095293⟩. ⟨hal-01622500⟩
  • Thomas Thibault, Jéril Degrouard, Patrick Baril, Chantal Pichon, Patrick Midoux, et al.. Production of DNA minicircles less than 250 base pairs through a novel concentrated DNA circularization assay enabling minicircle design with NF-κB inhibition activity. Nucleic Acids Research, Oxford University Press, 2017, 45 (5), pp.e26 - e26. ⟨10.1093/nar/gkw1034⟩. ⟨hal-01618796⟩
  • Javed Ahmad, Sohail Akhter, Md. Rizwanullah, Mohammad Ahmed Khan, Lucie Pigeon, et al.. Nanotechnology Based Theranostic Approaches in Alzheimer's Disease Management: Current Status and Future Perspective. Current Alzheimer Research, Bentham Science Publishers, 2017, 14 (11), ⟨10.2174/1567205014666170508121031⟩. ⟨hal-02068674⟩
  • Mathieu Berchel, Sohail Akhter, Wilfried Berthe, Cristine Gonçalvez, Marine Dubuisson, et al.. Synthesis of α-amino-lipophosphonates as cationic lipids or co-lipids for DNA transfection in dendritic cells. Journal of materials chemistry‎ B, Royal Society of Chemistry, 2017, J. Mater. Chem. B, pp.6869-6881 ⟨10.1039/C7TB01080J⟩. ⟨hal-01551638⟩
  • Wissem Deraredj Nadim, Simion Viorel, Hélène Bénédetti, Chantal Pichon, Patrick Baril, et al.. MicroRNAs in Neurocognitive Dysfunctions: New Molecular Targets for Pharmacological Treatments?. Current Neuropharmacology, Bentham Science Publishers, 2017, 15 (2), pp.260 - 275. ⟨10.2174/1570159X14666160709001441⟩. ⟨hal-01618199⟩
  • Viorel Simion, Wissem Deraredj Nadim, Hélène Bénédetti, Chantal Pichon, Séverine Morisset-Lopez, et al.. Pharmacomodulation of microRNA Expression in Neurocognitive Diseases: Obstacles and Future Opportunities. Current Neuropharmacology, Bentham Science Publishers, 2017, 15 (2), pp.276 - 290. ⟨10.2174/1570159X14666160630210422⟩. ⟨hal-01618771⟩
  • Mathilde Dréan, Antoine Debuigne, Cristine Gonçalves, Christine Jérôme, Patrick Midoux, et al.. Use of Primary and Secondary Polyvinylamines for Efficient Gene Transfection. Biomacromolecules, American Chemical Society, 2017, 18 (2), pp.440-451. ⟨10.1021/acs.biomac.6b01526⟩. ⟨hal-01427315⟩
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  • Ulysse Asseline, Cristine Gonçalves, Chantal Pichon, Patrick Midoux. Improved nuclear delivery of antisense 2′-Ome RNA by conjugation with the histidine-rich peptide H5WYG. The Journal of Gene Medicine, Wiley, 2014, 16 (7-8), pp.157-165. ⟨10.1002/jgm.2773⟩. ⟨hal-01175483⟩
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  • Delphine B Maurel, Delphine Benaitreau, Christelle Jaffré, Hechmi Toumi, Hugues Portier, et al.. Effect of the alcohol consumption on osteocyte cell processes: a molecular imaging study.. Journal of Cellular and Molecular Medicine, Wiley Open Access, 2014, 18 (8), pp.1680-1693. ⟨hal-01179388⟩
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  • Cristine Gonçalves, Fabian Gross, Philippe Guégan, Hervé Cheradame, Patrick Midoux. A robust transfection reagent for the transfection of CHO and HEK293 cells and production of recombinant proteins and lentiviral particles - PTG1. Biotechnology Journal, Wiley-VCH Verlag, 2014, 9 (11), pp.1380-1388. ⟨10.1002/biot.201400324⟩. ⟨hal-01179065⟩
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  • Yuliya Sedletska, Françoise Culard, Patrick Midoux, Jean-Marc Malinge. Interaction studies of muts and mutl with DNA containing the major cisplatin lesion and its mismatched counterpart under equilibrium and nonequilibrium conditions.. Biopolymers, Wiley, 2013, 99 (9), pp.636-47. ⟨10.1002/bip.22232⟩. ⟨hal-00874890⟩
  • Solenne Bire, David Gosset, Gwenhael Jegot, Patrick Midoux, Chantal Pichon, et al.. Exogenous mRNA delivery and bioavailability in gene transfer mediated by piggyBac transposition. BMC Biotechnology, BioMed Central, 2013, 13, pp.1-15. ⟨10.1186/1472-6750-13-75⟩. ⟨hal-01129780⟩
  • Lucie Pigeon, Cristine Gonçalves, David Gosset, Chantal Pichon, Patrick Midoux. An E3-14.7K Peptide that Promotes Microtubules-Mediated Transport of Plasmid DNA Increases Polyplexes Transfection Efficiency.. Small, Wiley-VCH Verlag, 2013, 9 (22), pp.3845-3851. ⟨10.1002/smll.201300217⟩. ⟨hal-00840172⟩
  • Anthony Delalande, Spiros Kotopoulis, Michiel Postema, Patrick Midoux, Chantal Pichon. Sonoporation: Mechanistic insights and ongoing challenges for gene transfer. Gene, Elsevier, 2013, 525 (2), pp.191-199. ⟨10.1016/j.gene.2013.03.095⟩. ⟨hal-02070788⟩
  • Sara Lacerda, Célia S Bonnet, Agnès Pallier, Sandrine Villette, Frédéric Foucher, et al.. Lanthanide-Based, Near-Infrared Luminescent and Magnetic Lipoparticles: Monitoring Particle Integrity.. Small, Wiley-VCH Verlag, 2013, 9 (16), pp.2662-2666. ⟨10.1002/smll.201201923⟩. ⟨hal-00817465⟩
  • Romain Félix, David Crottès, Anthony Delalande, J. Fauconnier, Yvon Lebranchu, et al.. The Orai-1 and STIM-1 Complex Controls Human Dendritic Cell Maturation. PLoS ONE, Public Library of Science, 2013, 8 (5), pp.e61595. ⟨10.1371/journal.pone.0061595⟩. ⟨inserm-01318483⟩
  • Julie Orio, Elisabeth Bellard, Houda Baaziz, Chantal Pichon, Peter Mouritzen, et al.. Sub-cellular temporal and spatial distribution of electrotransferred LNA/DNA oligomer.. Journal of RNAi and Gene Silencing, Library Publishing Media, 2013, 9, pp.479-85. ⟨hal-02071795⟩
  • Jean-Pierre Gomez, Chantal Pichon, Patrick Midoux. Ability of plasmid DNA complexed with histidinylated lPEI and lPEI to cross in vitro lung and muscle vascular endothelial barriers. Gene, Elsevier, 2013, 525 (2), pp.182-190. ⟨10.1016/j.gene.2013.03.055⟩. ⟨hal-02070843⟩
  • Alice Dubois, Patrick Midoux, Delphine Gras, Mustapha Si-Tahar, Deborah Brea, et al.. Poly- l -Lysine Compacts DNA, Kills Bacteria, and Improves Protease Inhibition in Cystic Fibrosis Sputum. American Journal of Respiratory and Critical Care Medicine, American Thoracic Society, 2013, 188 (6), pp.703-709. ⟨10.1164/rccm.201305-0912OC⟩. ⟨hal-02070798⟩
  • Patrick Midoux, Federico Perche, Olivier Lambert, Mathieu Berchel, Paul-Alain Jaffres, et al.. Gene transfer by histidylated lipopolyplexes: A dehydration method allowing preservation of their physicochemical parameters and transfection efficiency. International Journal of Pharmaceutics, Elsevier, 2012, 423 (1), pp.144 - 150. ⟨10.1016/j.ijpharm.2011.04.009⟩. ⟨hal-02995807⟩
  • Lynne Rudd, Chantal Pichon, Anthony Delalande. Ultrasound and microbubbles assisted-gene transfer: what is next?. Ultraschall in der Medizin, Georg Thieme Verlag, 2012, 33 (4), pp.391-3. ⟨hal-02071821⟩
  • Célia S Bonnet, Frédéric Buron, Fabien Caillé, Chad M Shade, Bohuslav Drahoš, et al.. Pyridine-based lanthanide complexes combining MRI and NIR luminescence activities.. Chemistry - A European Journal, Wiley-VCH Verlag, 2012, 18 (5), pp.1419-31. ⟨10.1002/chem.201102310⟩. ⟨hal-00720541⟩
  • Spiros Kotopoulis, Anthony Delalande, Chantal Pichon, Michiel Postema. Real-time sonoporation through HeLa cells. AIP Conference Proceedings, American Institute of Physics, 2012, NONLINEAR ACOUSTICS STATE-OF-THE-ART AND PERSPECTIVES: 19th International Symposium on Nonlinear Acoustics, 1474 (1), pp.271-274. ⟨10.1063/1.4749348⟩. ⟨hal-03186072v2⟩
  • Anthony Delalande, Michiel Postema, Nathalie Mignet, Patrick Midoux, Chantal Pichon. Ultrasound and microbubble-assisted gene delivery: recent advances and ongoing challenges. Therapeutic Delivery, Future Science Ltd, 2012, 3 (10), pp.1199-1215. ⟨10.4155/TDE.12.100⟩. ⟨hal-03193228⟩
  • Fabienne Godin, Sandrine Villette, Béatrice Vallée, Michel Doudeau, Séverine Morisset-Lopez, et al.. A fraction of neurofibromin interacts with PML bodies in the nucleus of the CCF astrocytoma cell line.. Biochemical and Biophysical Research Communications, Elsevier, 2012, 418 (4), pp.689-94. ⟨10.1016/j.bbrc.2012.01.079⟩. ⟨hal-00721861⟩
  • Anthony Delalande, Michiel Postema, Nathalie Mignet, Patrick Midoux, Chantal Pichon. Ultrasound and microbubble-assisted gene delivery: recent advances and ongoing challenges.. Ther Deliv, 2012, 3 (10), pp.1199-1215. ⟨hal-00817350⟩
  • Federico Perche, Olivier Lambert, Mathieu Berchel, Paul-Alain Jaffres, Chantal Pichon, et al.. Gene transfer by histidylated lipopolyplexes: A dehydration method allowing preservation of their physicochemical parameters and transfection efficiency.. International Journal of Pharmaceutics, Elsevier, 2012, 423 (1), pp.144-50. ⟨10.1016/j.ijpharm.2011.04.009⟩. ⟨hal-00726238⟩
  • Ludivine Billiet, Jean-Pierre Gomez, Mathieu Berchel, Paul-Alain Jaffres, Tony Le Gall, et al.. Gene transfer by chemical vectors, and endocytosis routes of polyplexes, lipoplexes and lipopolyplexes in a myoblast cell line.. Biomaterials, Elsevier, 2012, 33 (10), pp.2980-2990. ⟨10.1016/j.biomaterials.2011.12.027⟩. ⟨hal-00721795⟩
  • Mathieu Berchel, Tony Le Gall, Hélène Couthon, Jean-Pierre Haelters, Tristan Montier, et al.. Lipophosphonate/lipophosphoramidates: a family of synthetic vectors efficient for gene delivery.. Biochimie, Elsevier, 2012, 94 (1), pp.33-41. ⟨10.1016/j.biochi.2011.07.026⟩. ⟨hal-00721772⟩
  • Anthony Delalande, Ayache Bouakaz, Gilles Renault, Flore Tabareau, Spiros Kotopoulis, et al.. Ultrasound and microbubble-assisted gene delivery in Achilles tendons: long lasting gene expression and restoration of fibromodulin KO phenotype.. Journal of Controlled Release, Elsevier, 2011, 156 (2), pp.223-30. ⟨10.1016/j.jconrel.2011.08.020⟩. ⟨hal-00720602⟩
  • Emilie Bertrand, Cristine Gonçalves, Ludivine Billiet, Jean Pierre Gomez, Chantal Pichon, et al.. Histidinylated linear PEI: a new efficient non-toxic polymer for gene transfer.. Chemical Communications, Royal Society of Chemistry, 2011, 47 (46), pp.12547-12549. ⟨10.1039/c1cc15716g⟩. ⟨hal-00720539⟩
  • A. Delalande, S. Kotopoulis, T. Rovers, C. Pichon, M. Postema. Sonoporation at low mechanical index. Bubble Science, Engineering & Technology, Francis & Taylor, 2011, 3 (1), pp.3-12. ⟨10.1179/1758897911Y.0000000001⟩. ⟨hal-00608604⟩
  • Paul-Alain Jaffres, Aurore Fraix, Christophe Lorilleux, Mathieu Berchel, Hélène Couthon, et al.. New Lipo-Phosphoramidates for Gene Delivery. Phosphorus, Sulfur, and Silicon and the Related Elements, Taylor & Francis, 2011, 186 (4), pp.918-920. ⟨10.1080/10426507.2010.522639⟩. ⟨hal-00614938⟩
  • Véronique Bennevault-Celton, Allan Urbach, Olivier Martin, Chantal Pichon, Philippe Guégan, et al.. Supramolecular assemblies of histidinylated α-cyclodextrin in the presence of DNA scaffold during CDplexes formation.. Bioconjugate Chemistry, American Chemical Society, 2011, 22 (12), pp.2404-14. ⟨10.1021/bc200167p⟩. ⟨hal-00720527⟩
  • Patrick Baril, Yann Touchefeu, Jeannette Cany, Yan Cherel, Steve H Thorne, et al.. Differential biodistribution of oncolytic poxvirus administered systemically in an autochthonous model of hepatocellular carcinoma.. The Journal of Gene Medicine, Wiley, 2011, 13 (12), pp.692-701. ⟨10.1002/jgm.1624⟩. ⟨hal-00720514⟩
  • Marie Breton, Jean-François Berret, Claudie Bourgaux, Teresa Kral, Martin Hof, et al.. Protonation of lipids impacts the supramolecular and biological properties of their self-assembly.. Langmuir, American Chemical Society, 2011, 27 (20), pp.12336-45. ⟨10.1021/la202439s⟩. ⟨hal-00720543⟩
  • D. B. Maurel, Christelle Jaffré, G. Y. Rochefort, P. C. Aveline, Nathalie Boisseau, et al.. Low bone accrual is associated with osteocyte apoptosis in alcohol-induced osteopenia.. BONE, Elsevier, 2011, 49 (3), pp.543-52. ⟨10.1016/j.bone.2011.06.001⟩. ⟨hal-00720676⟩
  • Federico Perche, Thierry Benvegnu, Mathieu Berchel, Loic Lebegue, Chantal Pichon, et al.. Enhancement of dendritic cells transfection in vivo and of vaccination against B16F10 melanoma with mannosylated histidylated lipopolyplexes loaded with tumor antigen messenger RNA.. Nanomedicine: Nanotechnology, Biology and Medicine, Elsevier, 2011, 7 (4), pp.445-53. ⟨10.1016/j.nano.2010.12.010⟩. ⟨hal-00754373⟩
  • Federico Perche, David Gosset, Mathieu Mével, Marie-Laure Miramon, Jean-Jacques Yaouanc, et al.. Selective gene delivery in dendritic cells with mannosylated and histidylated lipopolyplexes.. Journal of Drug Targeting, Informa Healthcare, 2011, 19 (5), pp.315-25. ⟨10.3109/1061186X.2010.504262⟩. ⟨hal-00753554⟩
  • Mathieu Berchel, Jean-Piere Haelters, Hélène Couthon, Laure Deschamps, Patrick Midoux, et al.. Modular Construction of Fluorescent Lipophosphoramidates by Click Chemistry. European Journal of Organic Chemistry, Wiley-VCH Verlag, 2011, pp.6294-6303. ⟨10.1002/ejoc.201100900⟩. ⟨hal-00720537⟩
  • A. Delalande, Spiros Kotopoulis, Chantal Pichon, Michiel Postema. Sonoporation at a low MI. Ultrasound in Medicine & Biology, Elsevier, 2011, Official Proceedings of the 13th World Congress of the World Federation for Ultrasound in Medicine and Biology (WFUMB 2011), August 26-29, 2011 2011, Vienna, Austria, 37 (8, Suppl.), pp.S61. ⟨10.1016/j.ultrasmedbio.2011.05.284⟩. ⟨hal-03193243⟩
  • Anthony Delalande, Spiros Kotopoulis, Tijs Rovers, Chantal Pichon, Michiel Postema. Sonoporation at a low mechanical index. Bubble Science, Engineering & Technology, Francis & Taylor, 2011, 3 (1), pp.3-12. ⟨hal-03186064⟩
  • Anthony Delalande, Ayache Bouakaz, Gilles Renault, Flore Tabareau, Spiros Kotopoulis, et al.. Ultrasound and microbubble-assisted gene delivery in Achilles tendons: long lasting gene expression and restoration of fibromodulin KO phenotype. Journal of Controlled Release, Elsevier, 2011, 156 (2), pp.223-230. ⟨10.1016/j.jconrel.2011.08.020⟩. ⟨hal-03195121⟩
  • L. Gumez, S.F. Bensamoun, J. Doucet, O. Haddad, J.R. Hawse, et al.. Molecular structure of tail tendon fibers in TIEG1 knockout mice using synchrotron diffraction technology. Journal of Applied Physiology, American Physiological Society, 2010, 108 (6), pp.1706-1710. ⟨10.1152/japplphysiol.00356.2010⟩. ⟨hal-00624395⟩
  • Andrew Merron, Patrick Baril, Pilar Martin-Duque, Antonio de la Vieja, Lucile Tran, et al.. Assessment of the Na/I symporter as a reporter gene to visualize oncolytic adenovirus propagation in peritoneal tumours. European Journal of Nuclear Medicine and Molecular Imaging, Springer Verlag (Germany), 2010, 37 (7), pp.1377-1385. ⟨10.1007/s00259-009-1379-3⟩. ⟨hal-02086304⟩
  • Patrick Baril, Pilar Martin-Duque, Georges Vassaux. Visualization of gene expression in the live subject using the Na/I symporter as a reporter gene: applications in biotherapy. British Journal of Pharmacology, Wiley, 2010, 159 (4), pp.761-771. ⟨10.1111/j.1476-5381.2009.00412.x⟩. ⟨hal-02086340⟩
  • Jean Doucet, Fatma Briki, Aurélien Gourrier, Chantal Pichon, Laurie Gumez, et al.. Modeling the lateral organization of collagen molecules in fibrils using the paracrystal concept. Journal of Structural Biology, Elsevier, 2010, 173 (2), pp.197 - 201. ⟨10.1016/j.jsb.2010.11.018⟩. ⟨hal-01391584⟩
  • K. Kaddur, L. Lebegue, F. Tranquart, P. Midoux, C. Pichon, et al.. Transient transmembrane release of green fluorescent proteins with sonoporation. IEEE Transactions on Ultrasonics, Ferroelectrics and Frequency Control, Institute of Electrical and Electronics Engineers, 2010, 57 (7), pp.1558-1567. ⟨10.1109/TUFFC.2010.1586⟩. ⟨hal-00529340⟩
  • Matthieu Fisichella, Hinda Dabboue, Sanjib Bhattacharyya, Gerald Lelong, Marie-Louise Saboungi, et al.. Uptake of Functionalized Mesoporous Silica Nanoparticles by Human Cancer Cells. Journal of Nanoscience and Nanotechnology, American Scientific Publishers, 2010, 10 (4), pp.314-2324. ⟨10.1166/jnn.2010.1917⟩. ⟨hal-00529333⟩
  • Chantal Pichon, Ludivine Billiet, Patrick Midoux. Chemical vectors for gene delivery: uptake and intracellular trafficking. Current Opinion in Biotechnology, Elsevier, 2010, 21 (5), pp.640-645. ⟨10.1016/j.copbio.2010.07.003⟩. ⟨hal-00602488⟩
  • Anthony Delalande, Michel-Francis Bureau, Patrick Midoux, Ayache Bouakaz, Chantal Pichon. Ultrasound-assisted microbubbles gene transfer in tendons for gene therapy. Ultrasonics Sonochemistry, Elsevier, 2010, 50 (2), pp.269-272. ⟨10.1016/j.ultras.2009.09.035⟩. ⟨hal-00529321⟩
  • Arnaud Suwalski, Hinda Dabboue, Anthony Delalande, Sabine F. Bensamoun, Francis Canon, et al.. Accelerated Achilles tendon healing by PDGF gene delivery with mesoporous silica nanoparticles. Biomaterials, Elsevier, 2010, 31 (19), pp.5237-5245. ⟨10.1016/j.biomaterials.2010.02.077⟩. ⟨hal-00529475⟩
  • Patrick Midoux, Chantal Pichon, Jean-Jacques Yaouanc, Paul-Alain Jaffres. Chemical vectors for gene delivery: a current review on polymers, peptides and lipids containing histidine or imidazole as nucleic acids carriers. British Journal of Pharmacology, Wiley, 2009, 157 (2), pp.166-178. ⟨10.1111/j.1476-5381.2009.00288.x⟩. ⟨hal-00525108⟩
  • Edward Chisholm, Georges Vassaux, Pilar Martin-Duque, Raphaël Chèvre, Olivier Lambert, et al.. Cancer-Specific Transgene Expression Mediated by Systemic Injection of Nanoparticles. Cancer Research, American Association for Cancer Research, 2009, 69 (6), pp.2655-2662. ⟨10.1158/0008-5472.CAN-08-2657⟩. ⟨hal-02086345⟩
  • Inge Peerlinck, Andrew Merron, Patrick Baril, Sophie Conchon, Pilar Martin-Duque, et al.. Targeted Radionuclide Therapy Using a Wnt-Targeted Replicating Adenovirus Encoding the Na/I Symporter. Clinical Cancer Research, American Association for Cancer Research, 2009, 15 (21), pp.6595-6601. ⟨10.1158/1078-0432.CCR-09-0262⟩. ⟨hal-02086310⟩
  • Ming-Shen Dai, Josianne Nitcheu-Tefit, Sally Alcock, Francisco Ramirez-Jimenez, Tsu-Yi Chao, et al.. Development of an Escherichia coli Expressing Listeriolysin-O Vaccine Against Wilms Tumor Gene 1-expressing Tumors. Journal of Immunotherapy, Lippincott, Williams & Wilkins, 2009, 32 (8), pp.845-855. ⟨10.1097/CJI.0b013e3181aee259⟩. ⟨hal-02086312⟩
  • Corinne Bure, Chantal Pichon, Patrick Midoux. Involvement of histidines 11, 15 and 19 in the binding of zinc to the fusogenic H5WYG peptide. Journal of Mass Spectrometry, Wiley-Blackwell, 2009, 44 (8), pp.1163-1170. ⟨10.1002/jms.1591⟩. ⟨hal-00521851⟩
  • Corinne Bure, Régine Maget, Agnès F. Delmas, Chantal Pichon, Patrick Midoux. Histidine-rich peptide: evidence for a single zinc-binding site on H5WYG peptide that promotes membrane fusion at neutral pH. Journal of Mass Spectrometry, Wiley-Blackwell, 2009, 44 (1), pp.81-89. ⟨10.1002/jms.1473⟩. ⟨hal-00521834⟩
  • Cristine Gonçalves, Marie-Yvonne Ardourel, Martine Decoville, Gilles Breuzard, Patrick Midoux, et al.. An optimized extended DNA kappa B site that enhances plasmid DNA nuclear import and gene expression. The Journal of Gene Medicine, Wiley, 2009, 11 (5), pp.401-411. ⟨10.1002/jgm.1312⟩. ⟨hal-00522437⟩
  • Marie Breton, Jeanne Leblond, Johanne Seguin, Patrick Midoux, Daniel Scherman, et al.. Comparative gene transfer between cationic and thiourea lipoplexes. The Journal of Gene Medicine, Wiley, 2009, 12 (1), pp.45-54. ⟨10.1002/jgm.1417⟩. ⟨hal-02512540⟩
  • Valerie Boutin, Alain Legrand, Roger Mayer, Maurice Nachtigal, Michel Monsigny, et al.. Glycofection: The Ubiquitous Roles of Sugar Bound on Glycoplexes. Drug Delivery, Taylor & Francis, 2008, 6 (1), pp.45-50. ⟨10.1080/107175499267156⟩. ⟨hal-02138035⟩
  • N. Bonnet, C. L. Benhamou, L. Malaval, C. Goncalves, L. Vico, et al.. Low dose beta-blocker prevents ovariectomy-induced bone loss in rats without affecting heart functions.. Journal of Cellular Physiology, Wiley, 2008, 217 (3), pp.819-827. ⟨10.1002/jcp.21564⟩. ⟨hal-00407988⟩
  • T Harada, C. Chelala, B Bhakta, T Chaplin, K Caulee, et al.. Genome-wide DNA copy number analysis in pancreatic cancer using high-density single nucleotide polymorphism arrays. Oncogene, Nature Publishing Group, 2008, 27 (13), pp.1951-1960. ⟨10.1038/sj.onc.1210832⟩. ⟨hal-02086360⟩
  • Mathieu Mével, Jean-Jacques Yaouanc, Pascal Laurent, Claude Clément, Dominique Cartier, et al.. Cationic Lipids Based on Phosphonate and Phosphoramidate Chemistry: Synthesis and Application to Gene Therapy. Phosphorus, Sulfur, and Silicon and the Related Elements, Taylor & Francis, 2008, 183 (2-3), pp.460 - 468. ⟨10.1080/10426500701761300⟩. ⟨hal-01580434⟩
  • M. Mevel, C. Neveu, Cristine Goncalves, J.-J. Yaouanc, Chantal Pichon, et al.. Novel neutral imidazole-lipophosphoramides for transfection assays. Chemical Communications, Royal Society of Chemistry, 2008, pp.3124-3126. ⟨10.1039/b805226c⟩. ⟨hal-00518192⟩
  • M. Mevel, Gilles Breuzard, J.-J. Yaouanc, J.-C. Clement, P. Lehn, et al.. Synthesis and transfection activity of new cationic phosphoramidate lipids: High efficiency of an imidazolium derivative. ChemBioChem, Wiley-VCH Verlag, 2008, 9 (9), pp.1462-1471. ⟨10.1002/cbic.200700727⟩. ⟨hal-00518184⟩
  • Kadija Kaddur, Anthony Delalande, François Tranquart, Patrick Midoux, Chantal Pichon, et al.. Extraction of green fluorescent proteins with sonoporation. Journal of the Acoustical Society of America, Acoustical Society of America, 2008, 123 (5), pp.3218-3218. ⟨10.1121/1.2933412⟩. ⟨hal-02128161⟩
  • Gilles Breuzard, Magdalena Tertil, Cristine Gonçalves, Hervé Cheradame, Philippe Géguan, et al.. Nuclear delivery of NFkappaB-assisted DNA/polymer complexes: plasmid DNA quantitation by confocal laser scanning microscopy and evidence of nuclear polyplexes by FRET imaging.. Nucleic Acids Research, Oxford University Press, 2008, 36 (12), pp.e71. ⟨10.1093/nar/gkn287⟩. ⟨hal-00408004⟩
  • Chantal Pichon, Kadija Kaddur, Patrick Midoux, François Tranquart, Ayache Bouakaz. Recent advances in gene delivery with ultrasound and microbubbles. Journal of Experimental Nanoscience, Taylor & Francis, 2008, 3 (1), pp.17-40. ⟨10.1080/17458080801993422⟩. ⟨hal-00518203⟩
  • Evelyne Lopez-Crapez, Jean-Marc Malinge, François Gatchitch, Laetitia Casano, Thierry Langlois, et al.. A homogeneous resonance energy transfer-based assay to monitor MutS/DNA interactions.. Analytical Biochemistry, Elsevier Masson, 2008, 383 (2), pp.301-6. ⟨10.1016/j.ab.2008.09.004⟩. ⟨hal-00346456⟩
  • Patrick Midoux, Gilles Breuzard, Jean-Pierre Gomez, Chantal Pichon. Polymer-Based Gene Delivery: A Current Review on the Uptake and Intracellular Trafficking of Polyplexes. Current Gene Therapy, Bentham Science Publishers, 2008, 8 (5), pp.335-352. ⟨hal-00518197⟩
  • S. Bensamoun, L. Gumez, J. Hawse, M. Subramaniam, F. Briki, et al.. Comparison of tendon fiber structures between wild type and TIEG knockout mice using synchrotron microdiffraction. Computer Methods in Biomechanics and Biomedical Engineering, Taylor & Francis, 2008, 11 (sup001), pp.29 - 30. ⟨10.1080/10255840802296889⟩. ⟨hal-01391846⟩
  • Maria Castellano-Castillo, Hana Kostrhunova, Victoria Marini, Jana Kasparkova, Peter J Sadler, et al.. Binding of mismatch repair protein MutS to mispaired DNA adducts of intercalating ruthenium(II) arene complexes.. Journal of Biological Inorganic Chemistry, Springer Verlag, 2008, 13 (6), pp.993-999. ⟨10.1007/s00775-008-0386-3⟩. ⟨hal-00408036⟩
  • Carolina Belmar-Lopez, Pablo Mancheno-Corvo, Maria Antonia Saornil, Patrick Baril, Georges Vassaux, et al.. Uveal vs. cutaneous melanoma. Origins and causes of the differences.. Clinical and Translational Oncology, Springer, 2008, 10 (3), pp.137-42. ⟨hal-02086350⟩
  • Patrick Mahon, Patrick Baril, Vipul Bhakta, Claude Chelala, Krishna Caulee, et al.. S100A4 Contributes to the Suppression of BNIP3 Expression, Chemoresistance, and Inhibition of Apoptosis in Pancreatic Cancer. Cancer Research, American Association for Cancer Research, 2007, 67 (14), pp.6786-6795. ⟨10.1158/0008-5472.CAN-07-0440⟩. ⟨hal-02086365⟩
  • T Harada, P Baril, R Gangeswaran, G Kelly, C. Chelala, et al.. Identification of genetic alterations in pancreatic cancer by the combined use of tissue microdissection and array-based comparative genomic hybridisation. British Journal of Cancer, Cancer Research UK, 2007, 96 (2), pp.373-382. ⟨10.1038/sj.bjc.6603563⟩. ⟨hal-02086372⟩
  • Gilles Breuzard, M. Tertil, Chantal Pichon, Patrick Midoux. Intracellular trafficking and nuclear import of polyplexes by FRET coupled with cellular imaging. Human Gene Therapy, Mary Ann Liebert, 2007, 18, pp.1048. ⟨hal-00275215⟩
  • K. Kaddur, P. Palanchon, F. Tranquart, C. Pichon, A. Bouakaz. Sonopermeabilization: therapeutic alternative with ultrasound and microbubbles. Journal de Radiologie, Elsevier Masson, 2007, 88 (11 part 2), pp.1777-1786. ⟨hal-00282410⟩
  • M. Mockey, E Bourseau, V Chandrashekhar, A. Chaudhuri, S. Lafosse, et al.. mRNA-based cancer vaccine: prevention of B16 melanoma progression and metastasis by systemic injection of MART1 mRNA histidylated lipopolyplexes. Cancer Gene Therapy, Nature Publishing Group, 2007, 14 (9), pp.802-814. ⟨10.1038/sj.cgt.7701072⟩. ⟨hal-03065277⟩
  • Yuliya Sedletskaa, Laurence Fourrier, Jean-Marc Malinge. Modulation of MutS ATP-dependent functional activities by DNA containing a cisplatin compound lesion (base damage and mismatch. Journal of Molecular Biology, Elsevier, 2007, 369 (1), pp.27-40. ⟨10.1016/j.jmb.2007.02.048⟩. ⟨hal-00164883⟩
  • Eric Mennesson, Patrick Erbacher, Mateusz Kuzak, Claudine Kieda, Patrick Midoux, et al.. DNA/cationic polymer complex attachment on a human vascular endothelial cell monolayer exposed to a steady laminar flow. Journal of Controlled Release, Elsevier, 2006, 114 (3), pp.389-397. ⟨10.1016/j.jconrel.2006.06.006⟩. ⟨hal-00112894⟩
  • M. Mockey, C. Goncalves, F.P. Dupuy, F.M. Lemoine, C. Pichon, et al.. mRNA transfection of dendritic cells: synergistic effect of ARCA mRNA capping with Poly(A) chains in cis and in trans for a high protein expression level. Biochemical and Biophysical Research Communications, Elsevier, 2006, 340, pp.1062-1068. ⟨10.1016/j.bbrc.2005.12.105⟩. ⟨hal-00088921⟩
  • Y. Sedletska, M.J. Giraud-Panis, J.M. Malinge. Cisplatin is a DNA-damaging antitumour compound triggering multifactorial biochemical responses in cancer cells: importance of apoptotic pathways. Current medicinal chemistry. Anti-cancer agents., 2005, 5, pp.251-265. ⟨hal-00088712⟩
  • E. Mennesson, P. Erbacher, V. Piller, C. Kieda, P. Midoux, et al.. Transfection efficiency and uptake process of polyplexes in human lung endothetial cells: a comparative study in non-polarized and polarized cells. The Journal of Gene Medicine, Wiley, 2005, 7, pp.729-738. ⟨hal-00088642⟩
  • R.S. Singh, C. GonÇalves, P. Sandrin, C. Pichon, P. Midoux, et al.. On the gene delivery efficacies of pH-sensitive cationic lipids via endosomal protonation: a chemical biology investigation. Chemistry & biology, 2004, 11, pp.713-723. ⟨hal-00088426⟩
  • A. Kamal, B.A. Kumar, M. Arifuddin, P. Midoux. An efficient and facile nitration of phenols with nitric acid/zinc chloride under ultrasonic conditions. Ultrasonics sonochemistry., 2004, 11, pp.455-457. ⟨hal-00088378⟩
  • T. Montier, P. DelÉpine, C. Pichon, C. Férec, D.J. Porteous, et al.. Non-viral vectors in cystic fibrosis gene therapy: progress and challenges. Trends in biotechnology., 2004, 22, pp.586-592. ⟨hal-00088424⟩
  • Ibrahim Elmadbouh, Patrick Rossignol, Olivier Meilhac, Roger Vranckx, Chantal Pichon, et al.. Optimization of in vitro vascular cell transfection with non-viral vectors for in vivo applications. The Journal of Gene Medicine, Wiley, 2004, 6 (10), pp.1112-1124. ⟨hal-00014241⟩
  • C. Goncalves, E. Mennesson, R. Fuchs, Gorvel J.P., Patrick Midoux, et al.. Macropinocytosis of polyplexes and recycling of plasmid via the clathrin-dependant pathway impair the transfection efficiency into human hepatocarcinoma cells. Molecular Therapy, Nature Publishing Group, 2004, 10, pp.373-385. ⟨hal-00113047⟩
  • Laurence Fourrier, Peter Brooks, Jean-Marc Malinge. Binding Discrimination of MutS to a Set of Lesions and Compound Lesions (Base Damage and Mismatch) Reveals Its Potential Role as a Cisplatin-damaged DNA Sensing Protein. Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 2003, 278 (23), pp.21267-21275. ⟨10.1074/jbc.M301390200⟩. ⟨hal-02132054⟩
  • Chantal Pichon, Eric Lecam, Brigitte Guérin, Dominique Coulaud, Etienne Delain, et al.. Poly[Lys-(AEDTP)]: a cationic polymer that allows dissociation of pDNA/cationic polymer complexes in a reductive medium and enhances polyfection.. Bioconjugate Chemistry, American Chemical Society, 2002, 13 (1), pp.76-82. ⟨hal-02135235⟩
  • Chantal Pichon, Brigitte Guérin, Matthieu Refregiers, Christine Gonçalves, Paul Vigny, et al.. Zinc improves gene transfer mediated by DNA/cationic polymer complexes. The Journal of Gene Medicine, Wiley, 2002, 4 (5), pp.548 - 559. ⟨10.1002/jgm.303⟩. ⟨hal-01596013⟩
  • V Kumar, Chantal Pichon, M. Refregiers, B Guerin, P. Midoux, et al.. Single histidine residue in head-group region is sufficient to impart remarkable gene transfection properties to cationic lipids: evidence for histidine-mediated membrane fusion at acidic pH. Gene Therapy, Nature Publishing Group, 2002, 10 (15), pp.1206 - 1215. ⟨10.1038/sj.gt.3301979⟩. ⟨hal-01596052⟩
  • Eva Montero, José Pérez, Annie Schwartz, Miguel Fuertes, Jean-Marc Malinge, et al.. Apoptosis induction and DNA interstrand cross-link formation by cytotoxic trans-[PtCl2(NH(CH3)2)(NHCH(CH3)2) : cross-linking between d(G) and complementary d(C) within oligonucleotide duplexes.. ChemBioChem, Wiley-VCH Verlag, 2002, 3 (1), pp.61-7. ⟨hal-02132063⟩
  • Christine Gonçalves, Chantal Pichon, Brigitte Guérin, Patrick Midoux. Intracellular processing and stability of DNA complexed with histidylated polylysine conjugates. The Journal of Gene Medicine, Wiley, 2002, 4 (3), pp.271-281. ⟨10.1002/jgm.277⟩. ⟨hal-02135970⟩
  • Patrick Midoux, Eric Le Cam, Dominique Coulaud, Etienne Delain, Chantal Pichon. Histidine containing peptides and polypeptides as nucleic acid vectors.. Somatic Cell and Molecular Genetics, Springer Verlag, 2002, 27 (1/6), pp.27-47. ⟨10.1023/a:1022931923153⟩. ⟨hal-03065331⟩
  • Chantal Pichon, Eric Le Cam, Brigitte Guérin, Dominique Coulaud, Etienne Delain, et al.. Poly[Lys-(AEDTP)]: A Cationic Polymer That Allows Dissociation of pDNA/Cationic Polymer Complexes in a Reductive Medium and Enhances Polyfection. Bioconjugate Chemistry, American Chemical Society, 2002, 13 (1), pp.76-82. ⟨10.1021/bc015503o⟩. ⟨hal-03065338⟩
  • Patrick Midoux, Eric Lecam, Dominique Coulaud, Etienne Delain, Chantal Pichon. Histidine containing peptides and polypeptides as nucleic acid vectors.. Somatic Cell and Molecular Genetics, Springer Verlag, 2002, 27 (1-6), pp.27-47. ⟨10.1023/A:1022931923153⟩. ⟨hal-02163743⟩
  • J Ohan, M.A Gilbert, G Leseche, Y Panis, P. Midoux, et al.. Nonviral gene transfer into primary cultures of human and porcine mesothelial cells.. In Vitro Cellular & Developmental Biology - Animal, Springer, 2001, 37 (7), pp.402-7. ⟨hal-02161118⟩
  • M Bello Roufaï, P. Midoux. Histidylated polylysine as DNA vector: elevation of the imidazole protonation and reduced cellular uptake without change in the polyfection efficiency of serum stabilized negative polyplexes.. Bioconjugate Chemistry, American Chemical Society, 2001, 12 (1), pp.92-9. ⟨10.1021/bc0000738⟩. ⟨hal-02161122⟩
  • Chantal Pichon, C Gonçalves, P. Midoux. Histidine-rich peptides and polymers for nucleic acids delivery.. Advanced Drug Delivery Reviews, Elsevier, 2001, 53 (1), pp.75-94. ⟨hal-02135973⟩
  • L. Fourrier, Jean-Marc Malinge, P. Brooks. Analysis of the binding of MutS to cisplatin-modified DNA. Journal of Inorganic Biochemistry, Elsevier, 2001, 86 (1), pp.220. ⟨hal-02171267⟩
  • Jean-Marc Malinge, Marie-Josèphe Giraud-Panis, Marc Leng. Erratum to: “Interstrand cross-links of cisplatin induce striking distortions in DNA”. Journal of Inorganic Biochemistry, Elsevier, 2000, 81 (1-2), pp.119. ⟨10.1016/s0162-0134(00)00112-4⟩. ⟨hal-02134167⟩
  • Chantal Pichon, Mahajoub Bello Roufaï, Michel Monsigny, Patrick Midoux. Histidylated oligolysines increase the transmembrane passage and the biological activity of antisense oligonucleotides. Nucleic Acids Research, Oxford University Press, 2000, 28 (2), pp.504-512. ⟨10.1093/nar/28.2.504⟩. ⟨hal-02135979⟩
  • I. Freulon, M. Monsigny, P. Midoux, R. Mayer. Spacer length dependence on the efficiency of dimeric anionic peptides in gene transfer by glycosylated polylysine/plasmid complexes.. Bioscience Reports, Portland Press, 2000, 20 (5), pp.383-398. ⟨10.1023/a:1010382001654⟩. ⟨hal-02161127⟩
  • J.C Allo, Patrick Midoux, Marc Merten, Evelyne Souil, Joanna Lipecka, et al.. Efficient Gene Transfer into Human Normal and Cystic Fibrosis Tracheal Gland Serous Cells with Synthetic Vectors. American Journal of Respiratory Cell and Molecular Biology, American Thoracic Society, 2000, 22 (2), pp.166-175. ⟨10.1165/ajrcmb.22.2.3722⟩. ⟨hal-02161132⟩
  • Isabelle Fajac, J.C Allo, Evelyne Souil, Marc Merten, Chantal Pichon, et al.. Histidylated polylysine as a synthetic vector for gene transfer into immortalized cystic fibrosis airway surface and airway gland serous cells. The Journal of Gene Medicine, Wiley, 2000, 2 (5), pp.368-378. ⟨10.1002/1521-2254(200009/10)2:5<368::AID-JGM118>3.0.CO;2-F⟩. ⟨hal-02135988⟩
  • Fabien Dorange, Slimane El Mehdaoui, Chantal Pichon, Pierre Coursaget, Jean-François Vautherot. Marek’s disease virus (MDV) homologues of herpes simplex virus type 1 UL49 (VP22) and UL48 (VP16) genes: high-level expression and characterization of MDV-1 VP22 and VP16. Journal of General Virology, Microbiology Society, 2000, 81 (9), pp.2219-2230. ⟨10.1099/0022-1317-81-9-2219⟩. ⟨hal-02135997⟩
  • Jean-Marc Malinge, Marie-Josèphe Giraud-Panis, Marc Leng. Interstrand cross-links of cisplatin induce striking distortions in DNA. Journal of Inorganic Biochemistry, Elsevier, 1999, 77 (1-2), pp.23-29. ⟨10.1016/s0162-0134(99)00148-8⟩. ⟨hal-02134169⟩
  • Franck Coste, J.-M. Malinge, L. Serre, W. Shepard, M. Roth, et al.. Crystal structure of a double-stranded DNA containing a cisplatin interstrand cross-link at 1.63 A resolution: Hydration at the platinated site. Nucleic Acids Research, Oxford University Press, 1999, 27 (8), pp.1837-1846. ⟨10.1093/nar/27.8.1837⟩. ⟨hal-02127640⟩
  • Chantal Pichon, Michel Monsigny, Annie-Claude Roche. Intracellular Localization of Oligonucleotides: Influence of Fixative Protocols. Antisense and Nucleic Acid Drug Development, Mary Ann Liebert, 1999, 9 (1), pp.89-93. ⟨10.1089/oli.1.1999.9.89⟩. ⟨hal-02135999⟩
  • Patrick Midoux, Michel Monsigny. Efficient Gene Transfer by Histidylated Polylysine/pDNA Complexes. Bioconjugate Chemistry, American Chemical Society, 1999, 10 (3), pp.406-411. ⟨10.1021/bc9801070⟩. ⟨hal-02161145⟩
  • Antoine Kichler, Isabelle Freulon, Valerie Boutin, Roger Mayer, Michel Monsigny, et al.. GlycofectionTM in the presence of anionic fusogenic peptides: a study of the parameters affecting the peptide-mediated enhancement of the transfection efficiency. The Journal of Gene Medicine, Wiley, 1999, 1 (2), pp.134-143. ⟨10.1002/(SICI)1521-2254(199903/04)1:2<134::AID-JGM17>3.0.CO;2-B⟩. ⟨hal-02161144⟩
  • Isabelle Fajac, Pascale Briand, Michel Monsigny, Patrick Midoux. Sugar-Mediated Uptake of Glycosylated Polylysines and Gene Transfer into Normal and Cystic Fibrosis Airway Epithelial Cells. Human Gene Therapy, Mary Ann Liebert, 1999, 10 (3), pp.395-406. ⟨10.1089/10430349950018841⟩. ⟨hal-02161152⟩
  • Christophe Quétard, Sylvain Bourgerie, Nadia Normand-Sdiqui, Roger Mayer, Gérard Strecker, et al.. Novel Glycosynthons for Glycoconjugate Preparation: Oligosaccharylpyroglutamylanilide Derivatives. Bioconjugate Chemistry, American Chemical Society, 1998, 9 (2), pp.268-276. ⟨10.1021/bc970122p⟩. ⟨hal-02161157⟩
  • Patrick Midoux, Antoine Kichler, Valerie Boutin, Jean-Claude Maurizot, Michel Monsigny. Membrane Permeabilization and Efficient Gene Transfer by a Peptide Containing Several Histidines. Bioconjugate Chemistry, American Chemical Society, 1998, 9 (2), pp.260-267. ⟨10.1021/bc9701611⟩. ⟨hal-02161162⟩
  • M Monsigny, C. Quétard, S. Bourgerie, D. Delay, Chantal Pichon, et al.. Glycotargeting: the preparation of glyco-amino acids and derivatives from unprotected reducing sugars.. Biochimie, Elsevier, 1998, 80 (2), pp.99-108. ⟨hal-02136005⟩
  • Patrick Erbacher, Annie Claude Roche, Michel Monsigny, Patrick Midoux. Specific Gene Transfer Based on Biotinylated and Gluconoylated Polylysine/Plasmid Complexes. Drug Delivery, Taylor & Francis, 1997, 4 (3), pp.173-179. ⟨10.3109/10717549709051889⟩. ⟨hal-02161332⟩
  • Cécile Perez, Marc Leng, Jean-Marc Malinge. Rearrangement of interstrand cross-links into intrastrand cross-links in cis-diamminedichloroplatinum(II)-modified DNA. Nucleic Acids Research, Oxford University Press, 1997, 25 (4), pp.896-903. ⟨10.1093/nar/25.4.896⟩. ⟨hal-02134171⟩
  • Wouter Kollen, Patrick Erbacher, Patrick Midoux, Annie-Claude Roche, Michel Monsigny, et al.. Glycosylated Polylysines. Nonviral vectors for gene transfer into cystic fibrosis airway epithelial cells.. Chest, American College of Chest Physicians, 1997, 111 (6), pp.95S-96S. ⟨10.1378/chest.111.6_supplement.95s⟩. ⟨hal-02161319⟩
  • Chantal Pichon, Isabelle Freulon, Patrick Midoux, Roger Mayer, Michel Monsigny, et al.. Cytosolic and Nuclear Delivery of Oligonucleotides Mediated by an Amphiphilic Anionic Peptide. Antisense and Nucleic Acid Drug Development, Mary Ann Liebert, 1997, 7 (4), pp.335-343. ⟨10.1089/oli.1.1997.7.335⟩. ⟨hal-02136009⟩
  • Patrick Erbacher, Annie Claude Roche, Michel Monsigny, Patrick Midoux. The reduction of the positive charges of polylysine by partial gluconoylation increases the transfection efficiency of polylysine/DNA complexes. Biochimica et Biophysica Acta:Biomembranes, Elsevier, 1997, 1324 (1), pp.27-36. ⟨10.1016/s0005-2736(96)00204-0⟩. ⟨hal-02161372⟩
  • A.J. Stewart, Chantal Pichon, Patrick Midoux, R. Mayer, Michel Monsigny, et al.. Fluorescent labelling of unmodified phosphorothioate oligodeoxynucleotides: Synthesis and characterization. New Journal of Chemistry, Royal Society of Chemistry, 1997, 21 (1), pp.87-98. ⟨hal-02161369⟩
  • Françoise Paquet, C. Perez, M. Leng, G. Lancelot, J-M Malinge. NMR Solution Structure of a DNA Decamer Containing an Interstrand Cross-link of the Antitumor Drug cis -diamminedichloroplatinum(II). Journal of Biomolecular Structure and Dynamics, Taylor & Francis: STM, Behavioural Science and Public Health Titles, 1997, 14 (1), pp.67-77. ⟨10.1080/07391102.1996.10508930⟩. ⟨hal-02121444⟩
  • C Pichon, K Arar, A. Stewart, M Dodon, L Gazzolo, et al.. Intracellular routing and inhibitory activity of oligonucleopeptides containing a KDEL motif.. Molecular Pharmacology, American Society for Pharmacology and Experimental Therapeutics, 1997, 51 (3), pp.431-8. ⟨hal-02124430⟩
  • Alexandre Avraméas, Dorian Mcilroy, Anne Hosmalin, Brigitte Autran, Patrice Debré, et al.. Expression of a mannose/fucose membrane lectin on human dendritic cells. European Journal of Immunology, Wiley-VCH Verlag, 1996, 26 (2), pp.394-400. ⟨10.1002/eji.1830260219⟩. ⟨hal-02161396⟩
  • Patrick Erbacher, Annie Claude Roche, Michel Monsigny, Patrick Midoux. Putative Role of Chloroquine in Gene Transfer into a Human Hepatoma Cell Line by DNA/Lactosylated Polylysine Complexes. Experimental Cell Research, Elsevier, 1996, 225 (1), pp.186-194. ⟨10.1006/excr.1996.0169⟩. ⟨hal-02161382⟩
  • Wouter Kollen, Patrick Midoux, Patrick Erbacher, Alex Yip, Annie Claude Roche, et al.. Gluconoylated and Glycosylated Polylysines As Vectors for Gene Transfer into Cystic Fibrosis Airway Epithelial Cells. Human Gene Therapy, Mary Ann Liebert, 1996, 7 (13), pp.1577-1586. ⟨10.1089/hum.1996.7.13-1577⟩. ⟨hal-02161378⟩
  • Patrick Erbacher, Marie-Thérèse Bousser, Jacques Raimond, Michel Monsigny, Patrick Midoux, et al.. Gene Transfer by DNA/Glycosylated Polylysine Complexes into Human Blood Monocyte-Derived Macrophages. Human Gene Therapy, Mary Ann Liebert, 1996, 7 (6), pp.721-729. ⟨10.1089/hum.1996.7.6-721⟩. ⟨hal-02161390⟩
  • C. Perez, M. Leng, Jean-Marc Malinge. Instabilite des adduits interbrins formes dans la reaction entre le cis-dichlorodiammineplatine (II) et l'ADN. Bulletin du Cancer, John Libbey Eurotext, 1996. ⟨hal-02173073⟩
  • A. Stewart, Chantal Pichon, L Meunier, P Midoux, M. Monsigny, et al.. Enhanced biological activity of antisense oligonucleotides complexed with glycosylated poly-L-lysine.. Molecular Pharmacology, American Society for Pharmacology and Experimental Therapeutics, 1996, 50 (6), pp.1487-94. ⟨hal-02136015⟩
  • P Erbacher, A.C. Roche, M. Monsigny, P. Midoux. Glycosylated polylysine/DNA complexes: gene transfer efficiency in relation with the size and the sugar substitution level of glycosylated polylysines and with the plasmid size.. Bioconjugate Chemistry, American Chemical Society, 1995, 6 (4), pp.401-10. ⟨10.1021/bc00034a010⟩. ⟨hal-02161414⟩
  • Patrick Midoux, Roger Mayer, Michel Monsigny. Membrane permeabilization by α-helical peptides: a flow cytometry study. Biochimica et Biophysica Acta:Biomembranes, Elsevier, 1995, 1239 (2), pp.249-256. ⟨10.1016/0005-2736(95)00163-w⟩. ⟨hal-02161407⟩
  • Nadia Sdiqui, Khalil Arar, Patrick Midoux, Roger Mayer, Michel Monsigny, et al.. Inhibition of Human Mammary Cell Line Proliferation by Membrane Lectin-Mediated Uptake of Ha- ras Antisense Oligodeoxynucleotide. Drug Delivery, Taylor & Francis, 1994, 2 (1), pp.63-72. ⟨10.3109/10717549509031353⟩. ⟨hal-02161404⟩
  • Jean-Marc Malinge, Cécile Pérez, Marc Leng. Base sequence-independent distortions induced by interstrand cross-links in cis -diamminedichloroplatinum (ll)-modified DNA. Nucleic Acids Research, Oxford University Press, 1994, 22 (19), pp.3834-3839. ⟨10.1093/nar/22.19.3834⟩. ⟨hal-02134682⟩
  • Michel Monsigny, Annie-Claude Roche, Patrick Midoux, Roger Mayer. Glycoconjugates as carriers for specific delivery of therapeutic drugs and genes. Advanced Drug Delivery Reviews, Elsevier, 1994, 14 (1), pp.1-24. ⟨10.1016/0169-409X(94)90003-5⟩. ⟨hal-02163748⟩
  • Patrick Midoux, Christina Mendes, Alain Legrand, Jacques Raimond, Roger Mayer, et al.. Specific gene transfer mediated by lactosylated poly-L-lysine into hepatoma cells. Nucleic Acids Research, Oxford University Press, 1993, 21 (4), pp.871-878. ⟨10.1093/nar/21.4.871⟩. ⟨hal-02138456⟩
  • V. Carpentier, Patrick Midoux, M. Monsigny, A.C. Roche. Endocytosis of alpha 1-acid glycoprotein variants by human monocytic lineage cells.. Biology of the Cell, Wiley, 1993, 77 (2), pp.187-93. ⟨10.1016/S0248-4900(05)80187-X⟩. ⟨hal-02161453⟩
  • M. Monsigny, P. Midoux, A.C. Roche. Perspectives ex vivo et in vivo pour la thérapie génique, de la transfection sélective à l'aide de complexes plasmide-polylysine ciblés. médecine/sciences, EDP Sciences, 1993, 9 (4), pp.441. ⟨10.4267/10608/2938⟩. ⟨hal-02163755⟩
  • N Bonfils, C. Depierreux, P. Midoux, N.T. Thuong, M. Monsigny, et al.. Drug targeting: synthesis and endocytosis of oligonucleotide-neoglycoprotein conjugates. Nucleic Acids Research, Oxford University Press, 1992, 20 (17), pp.4621-4629. ⟨10.1093/nar/20.17.4621⟩. ⟨hal-02161479⟩
  • E Bonfils, C. Mendes, A.C. Roche, M. Monsigny, P. Midoux. Uptake by macrophages of a biotinylated oligo-alpha-deoxythymidylate by using mannosylated streptavidin.. Bioconjugate Chemistry, American Chemical Society, 1992, 3 (4), pp.277-284. ⟨10.1021/bc00016a004⟩. ⟨hal-02161474⟩
  • Patrick Midoux, A. Martin, B Collet, M. Monsigny, A.C. Roche, et al.. Activation of mouse macrophages by muramyl dipeptide coupled with an anti-macrophage monoclonal antibody.. Bioconjugate Chemistry, American Chemical Society, 1992, 3 (2), pp.194-9. ⟨10.1021/bc00014a016⟩. ⟨hal-02161456⟩
  • V Pimpaneau, Patrick Midoux, M. Monsigny, A.C. Roche. Characterization and isolation of an intracellular D-mannose-specific receptor from human promyelocytic HL60 cells.. Carbohydrate Research, Elsevier, 1991, 213, pp.95-108. ⟨10.1016/S0008-6215(00)90601-3⟩. ⟨hal-02162388⟩
  • Frédéric Gaucheron, Jean-Marc Malinge, A. John Blacker, Jean-Marie Lehn, Marc Leng. Possible catalytic activity of DNA in the reaction between the antitumor drug cis-diamminedichloroplatinum(II) and the intercalator N-methyl-2,7-diazapyrenium.. Proceedings of the National Academy of Sciences of the United States of America , National Academy of Sciences, 1991, 88 (9), pp.3516-3519. ⟨10.1073/pnas.88.9.3516⟩. ⟨hal-02134694⟩
  • P Breton, Patrick Midoux, Christian Petit, M Bousser, A.C Roche, et al.. Production of macrophage-derived cytotoxic factor by N-[3-[(carbamoylmethyl)thio]propionylated] neoglycoproteins.. Bioconjugate Chemistry, American Chemical Society, 1991, 2 (1), pp.16-8. ⟨hal-02162393⟩
  • Jean-Marc Malinge, Miroslav Sip, A.John Blacker, Jean-Marie Lehn, Marc Leng. Formation of a DNA monofunctional cis -platinum adduct cross-linking the intercalating drug N-methyl-2, 7-diazapyrenium. Nucleic Acids Research, Oxford University Press, 1990, 18 (13), pp.3887-3891. ⟨10.1093/nar/18.13.3887⟩. ⟨hal-02134706⟩
  • M Monsigny, Patrick Midoux, C. Depierreux, C Bebear, M.T Le Bris, et al.. Benzoxazinone kanamycin A conjugate. A new fluorescent probe suitable to detect mycoplasmas in cell culture.. Biology of the Cell, Wiley, 1990, 70 (3), pp.101-105. ⟨10.1016/0248-4900(90)90365-A⟩. ⟨hal-02163189⟩
  • Patrick Midoux, Eric Negre, Annie-Claude Roche, Roger Mayer, Michel Monsigny, et al.. Drug targeting: Anti-HSV-1 activity of mannosylated polymer-bound 9-(2-phosphonylmethoxyethyl)adenine. Biochemical and Biophysical Research Communications, Elsevier, 1990, 167 (3), pp.1044-1049. ⟨10.1016/0006-291x(90)90628-z⟩. ⟨hal-02163192⟩
  • M Monsigny, Patrick Midoux, M.T Le Bris, A.C Roche, B Valeur. Benzoxazinone derivatives: new fluorescent probes for two-color flow cytometry analysis using one excitation wavelength.. Biology of the Cell, Wiley, 1989, 67 (2), pp.193-200. ⟨10.1111/j.1768-322X.1989.tb00862.x⟩. ⟨hal-02163198⟩
  • V Pimpaneau, Patrick Midoux, Geoffroy Durand, P de Baetselier, M. Monsigny, et al.. Endocytosis of alpha 1-acid glycoprotein variants and of neoglycoproteins containing mannose derivatives by a mouse hybridoma cell line (2C11-12). Comparison with mouse peritoneal macrophages.. Glycoconjugate Journal, Springer Verlag, 1989, 6 (4), pp.561-574. ⟨10.1007/BF01053778⟩. ⟨hal-02163197⟩
  • Patrick Midoux, Christian Petit, P Pellen, L Toujas, M. Monsigny, et al.. Macrophage antigens associated with adhesion: identification by a monoclonal antibody specific for Lewis lung carcinoma cells.. Experimental Cell Research, Elsevier, 1989, 183 (1), pp.168-178. ⟨10.1016/0014-4827(89)90427-8⟩. ⟨hal-02163384⟩
  • D Derrien, Patrick Midoux, Christian Petit, E. Negre, R. Mayer, et al.. Muramyl dipeptide bound to poly-L-lysine substituted with mannose and gluconoyl residues as macrophage activators.. Glycoconjugate Journal, Springer Verlag, 1989, 6 (2), pp.241-255. ⟨10.1007/BF01050652⟩. ⟨hal-02163397⟩
  • Jean-Marc Malinge, M. Leng. Reactivity of monofunctional cis-platinum adducts as a function of DNA sequence.. Nucleic Acids Research, Oxford University Press, 1988, 16 (15), pp.7663-7672. ⟨hal-02134721⟩
  • M. Monsigny, A.C Roche, P. Midoux. Endogenous Lectins and Drug Targeting. Annals of the New York Academy of Sciences, Wiley, 1988, 551, pp.399-414. ⟨10.1111/j.1749-6632.1988.tb22373.x⟩. ⟨hal-02163799⟩
  • M Monsigny, Annie Claude Roche, C. Kieda, P. Midoux, A Obrénovitch. Characterization and biological implications of membrane lectins in tumor, lymphoid and myeloid cells.. Biochimie, Elsevier, 1988, 70 (11), pp.1633-49. ⟨10.1016/0300-9084(88)90299-4⟩. ⟨hal-02163758⟩
  • Jean-Marc Malinge, Annie Schwartz, M. Leng. Reaction of nucleic-acids with cis-dichlorodiammineplatinum (II) in the presence of intercalating agents - characterization of new ternary complexes. Bulletin du Cancer, John Libbey Eurotext, 1988, 75 (7), pp.668. ⟨hal-02171328⟩
  • Hj Gabius, R Engelhardt, T Hellmann, Patrick Midoux, M. Monsigny, et al.. Characterization of membrane lectins in human colon carcinoma cells by flow cytofluorometry, drug targeting and affinity chromatography.. Anticancer Research, International Institute of Anticancer Research, 1987, 7 (1), pp.109-112. ⟨hal-02163405⟩
  • Jean-Marc Malinge, Annie Schwartz, Marc Leng. Characterization of the ternary complexes formed in the reaction of cis-diamminedichloro platinum (II), ethidium bromide and nucleic acids. Nucleic Acids Research, Oxford University Press, 1987, 15 (4), pp.1779-1797. ⟨10.1093/nar/15.4.1779⟩. ⟨hal-02134724⟩
  • Patrick Midoux, Annie-Claude Roche, Michel Monsigny. Quantitation of the binding, uptake, and degradation of fluoresceinylated neoglycoproteins by flow cytometry. Cytometry, Wiley, 1987, 8 (3), pp.327-334. ⟨10.1002/cyto.990080314⟩. ⟨hal-02163401⟩
  • Patrick Midoux, A.C Roche, M. Monsigny. Estimation of the degradation of endocytosed material by flow cytofluorometry using two neoglycoproteins containing different numbers of fluorescein molecules.. Biology of the Cell, Wiley, 1986, 58 (3), pp.221-225. ⟨hal-02163590⟩
  • A Sève, J. Hubert, D. Bouvier, C. Bourgeois, P. Midoux, et al.. Analysis of sugar-binding sites in mammalian cell nuclei by quantitative flow microfluorometry.. Proceedings of the National Academy of Sciences of the United States of America , National Academy of Sciences, 1986, 83 (16), pp.5997-6001. ⟨10.1073/pnas.83.16.5997⟩. ⟨hal-02163583⟩
  • Jean-Marc Malinge, Marc Leng. Reaction of nucleic acids and cis-diamminedichloroplatinum(II) in the presence of intercalating agents.. Proceedings of the National Academy of Sciences of the United States of America , National Academy of Sciences, 1986, 83 (17), pp.6317-6321. ⟨10.1073/pnas.83.17.6317⟩. ⟨hal-02134715⟩
  • A. Rachid Rahmouni, Jean-Marc Malinge, Annie Schwartz, Marc Leng. Comparison Between poly(dG-dC)·poly(dG-dC) and DNA Modified by cis-diamminedichloroplatinum (II): Immunological and Spectroscopic Studies. Journal of Biomolecular Structure and Dynamics, Taylor & Francis: STM, Behavioural Science and Public Health Titles, 1985, 3 (2), pp.363-375. ⟨10.1080/07391102.1985.10508423⟩. ⟨hal-02127084⟩
  • Annie-Claude Roche, Patrick Midoux, Philippe Bouchard, Michel Monsigny. Membrane lectins on human monocytes. Maturation-dependent modulation of 6-phosphomannose and mannose receptors.. FEBS Letters, Wiley, 1985, 193 (1), pp.63-68. ⟨10.1016/0014-5793(85)80080-6⟩. ⟨hal-02163594⟩
  • B. Revet, E. Delain, Jean-Marc Malinge. MEASUREMENT OF THE LENGTH OF THE PERSISTENCE OF POLY(DG.DC) AND OF POLY(DG.M5DC) CROSS-LINKED WITH CIS-DIAMINEDICHLOROPLATINUM(II) (CIS-PT). Biology of the Cell, Wiley, 1985, 53 (3), pp.A44. ⟨hal-02171332⟩
  • Marc Leng, Jean-Marc Malinge, Marius Ptak. Importance of DNA conformation in the reaction with cis-dichlorodiammine platinum (II). Journal of Biosciences, Indian Academy of Sciences, 1985, 8 (3), pp.721-729. ⟨10.1007/bf02702770⟩. ⟨hal-02134748⟩
  • B. Revet, J.M. Malinge, E. Delain, M.Le Bret, M. Leng. Electron microscopic measurement of chain flexibility of poly(dG-dC.poly(dG-dC) modified by cis-diamminedichloroplatinum(II). Nucleic Acids Research, Oxford University Press, 1984, 12 (22), pp.8349-8362. ⟨10.1093/nar/12.22.8349⟩. ⟨hal-02134753⟩
  • Jean-Marc Malinge, Marius Ptak, Marc Leng. Immunological end spectroscopic studies of poly(dG-dC).poly(dG-dC) modified by cis-diamminedicholoroplatinum(II). Nucleic Acids Research, Oxford University Press, 1984, 12 (14), pp.5767-5778. ⟨10.1093/nar/12.14.5767⟩. ⟨hal-02134761⟩
  • Annie Claude Roche, P Bailly, Patrick Midoux, M. Monsigny. Selective macrophage activation by muramyldipeptide bound to monoclonal antibodies specific for mouse tumor cells.. Cancer Immunology, Immunotherapy, Springer Verlag, 1984, 18 (3), pp.155-159. ⟨hal-02163604⟩
  • Patrick Midoux, Thierry Maillet, Fabienne Therain, Michel Monsigny, Annie-Claude Roche. Tumor localization of Lewis lung carcinoma with radiolabeled monoclonal antibodies. Cancer Immunology, Immunotherapy, Springer Verlag, 1984, 18 (1), pp.19-23. ⟨10.1007/BF00205394⟩. ⟨hal-02163698⟩
  • Jean-Marc Malinge, M. Leng. Reaction of cis-diamminedichloroplatinum (II) and DNA in B or Z conformation.. EMBO Journal, EMBO Press, 1984, 3 (6), pp.1273-1279. ⟨hal-02134767⟩
  • Patrick Midoux, Annie-Claude Roche, M. Monsigny. Monoclonal antibodies (IgM) against a murine carcinoma, Lewis lung carcinoma (3LL): production, purification and in vitro selectivity.. Immunology Letters, Elsevier, 1984, 8 (3), pp.131-136. ⟨10.1016/0165-2478(84)90065-8⟩. ⟨hal-02163712⟩
  • M. Monsigny, Annie-Claude Roche, P. Midoux. Uptake of neoglycoproteins via membrane lectin(s) of L1210 cells evidenced by quantitative flow cytofluorometry and drug targeting.. Biology of the Cell, Wiley, 1984, 51 (2), pp.187-196. ⟨10.1111/j.1768-322X.1984.tb00298.x⟩. ⟨hal-02163609⟩
  • Patrick Midoux, Philippe Wahl, Jean-Claude Auchet, Michel Monsigny. Fluorescence quenching of tryptophan by trifluoroacetamide. Biochimica et Biophysica Acta (BBA) - General Subjects, Elsevier, 1984, 801 (1), pp.16-25. ⟨10.1016/0304-4165(84)90207-1⟩. ⟨hal-02163704⟩
  • P. Midoux, J.P Grivet, F. Delmotte, M. Monsigny. The binding of monosaccharides to wheat germ agglutinin: Fluorescence and NMR investigations. Biochemical and Biophysical Research Communications, Elsevier, 1984, 119 (2), pp.603-611. ⟨10.1016/s0006-291x(84)80292-2⟩. ⟨hal-02163716⟩
  • A.C Roche, M. Barzilay, P. Midoux, S. Junqua, N. Sharon, et al.. Sugar-specific endocytosis of glycoproteins by Lewis lung carcinoma cells. Journal of Cellular Biochemistry, Wiley, 1983, 22 (3), pp.131-140. ⟨10.1002/jcb.240220302⟩. ⟨hal-02163725⟩
  • P. Midoux, F. Delmotte, J.Ph Grivet, M. Monsigny. Protein-sugar interactions: Environmental effect on the fluorescence of O-(4-methylumbelliferyl)-glycosides. Biochemical and Biophysical Research Communications, Elsevier, 1983, 110 (3), pp.926-933. ⟨10.1016/0006-291X(83)91051-3⟩. ⟨hal-02163727⟩
  • M Midoux, J.-Ph. Grivet, M. Monsigny, P. Midoux. Lectin-sugar interactions: the binding of 1- O -methyl-di- N -trifluoroacetyl-β-chitobioside to wheat germ agglutinin. FEBS Letters, Wiley, 1980, 120 (1), pp.29-32. ⟨10.1016/0014-5793(80)81038-6⟩. ⟨hal-02163732⟩

Communication dans un congrès

  • Federico Perche. Séminaire invité : Délivrance d’ARN thérapeutique. Laboratoire Structure et Activité des Biomolécules Normales et Pathologies - U1204, Jun 2019, Evry, France. ⟨hal-02974301⟩
  • Vinodini Vijayarangan, Anthony Delalande, Sébastien Dozias, Jean-Michel Pouvesle, Chantal Pichon, et al.. Helium Plasma Jet for Cell Membrane Permeabilization and Drug Delivery Application. SFNano 2018, SFN, Dec 2018, Montpellier, France. ⟨hal-01946070⟩
  • Vinodini Vijayarangan, Anthony Delalande, Sébastien Dozias, Jean-Michel Pouvesle, Chantal Pichon, et al.. Cold Atmospheric Plasma Parameters Investigation for Drug Delivery Applications. ICPM7, ISPM, Jun 2018, Philadelphia, United States. ⟨hal-01942869⟩
  • Vinodini Vijayarangan, Anthony Delalande, Sébastien Dozias, Jean-Michel Pouvesle, Chantal Pichon, et al.. Helium Plasma Jet: A tool for Cell Membrane Permeabilization. Journées du GDR HAPPYBio, GDR HAPPYBio, Nov 2018, Paris, France. ⟨hal-01946046⟩
  • Phila Raharivelomanana, J.L. Ansel, E. Lupo, L. Mijouin, S. Guillot, et al.. Skin-active and cosmetic ingredient from French Polynesian Tamanu oil. 1st Congress of Lipids & Cosmetics top of Innovations & Research Initiatives, Jan 2018, Bordeaux, France. ⟨hal-02146459⟩
  • Vinodini Vijayarangan, Anthony Delalande, Dozias Sébastien, Jean-Michel Pouvesle, Chantal Pichon, et al.. Study of adherent cell permeabilization in various Plasma Gun plasma delivery protocols. 15th International Bioelectrics Symposium, Institute of Plasma Physics of the Czech Academy of Sciences, Sep 2018, Prague, Czech Republic. ⟨hal-02933738⟩
  • Phila Raharivelomanana, J.L. Ansel, E. Lupo, L. Mijouin, S. Guillot, et al.. French Polynesian Tamanu oil extracts bioactive effects on human skin cells. 7ème Congrès International des Plantes Aromatiques et Médicinales CIPAM 2018, Jun 2018, Toulouse, France. ⟨hal-02146453⟩
  • Phila Raharivelomanana, J.L. Ansel, E. Lupo, L. Mijouin, S. Guillot, et al.. Phytochemical assessment of “Tamanu oil”: a bridge from traditional uses to innovation and valuation of a Pacific plant. 3ème conférence du Réseau de Recherche des Universités du Pacifique Insulaire (PIURN), Université de la Polynésie française, Oct 2018, Punaauia, French Polynesia. ⟨hal-02146458⟩
  • Federico Perche. Séminaire invité : Délivrance d’ARN thérapeutique. Institut Galien Paris-Sud, Nov 2017, Chatenay-Malabry, France. ⟨hal-02974306⟩
  • Vinodini Vijayarangan, Anthony Delalande, Claire Douat, Sébastien Dozias, Jean-Michel Pouvesle, et al.. STUDY OF PLASMA COMPONENT EFFECT ON CELL MEMBRANE PERMEABILIZATION FOR DRUG DELIVERY APPLICATIONS. 23rd International Symposium on Plasma Chemistry, Jul 2017, Montreal, Canada. ⟨hal-01610921⟩
  • Vinodini Vijayarangan, Anthony Delalande, Sébastien Dozias, Jean-Michel Pouvesle, Chantal Pichon, et al.. Investigation of cell membrane permeabilization induced by plasma treatment for drug delivery applications. Journées du GDR ABioPlas, GDR ABioPlas, Oct 2017, Paris, France. ⟨hal-01945957⟩
  • Vinodini Vijayarangan, Anthony Delalande, Claire Douat, Sébastien Dozias, Jean-Michel Pouvesle, et al.. INVESTIGATION OF CELL MEMBRANE PERMEABILIZATION INDUCED BY PLASMA TREATMENT FOR DRUG DELIVERY APPLICATIONS. IWPCT4, Mar 2017, Paris, France. ⟨hal-01944604⟩
  • Claire Douat, Giovanni Busco, Vini Vijayarangan, Sebastien Dozias, Sylvain Iséni, et al.. Challenges in the transition from in vitro to in vivo experiments: source effects and biological aspects. IWPCT3, Apr 2016, Washington, United States. ⟨hal-01340223⟩
  • Eric Robert, Sylvain Iséni, Claire Douat, Vinodini Vijayarangan, Anthony Delalande, et al.. Non thermal plasma jets and plasma jet electric fields for biomedical and agricultural applications. 13th International Bioelctrics Symposium, Sep 2016, Rostock, Germany. ⟨hal-01944556⟩
  • Claire Douat, Vinodini Vijayarangan, Thibault Darny, Sylvain Iséni, Xavier Damany, et al.. Perméabilisation de la membrane plasmique par un jet de plasma. Journées du GDR ABioPlas, GDR ABioPlas, Nov 2016, Albi, France. ⟨hal-01945754⟩
  • Claire Douat, Thibault Darny, Sylvain Iseni, Xavier Damany, Sebastien Dozias, et al.. Impact of electric field from a plasma jet on biological targets. 69th Gaseous Electronic Conference, Oct 2016, Bochum, Germany. ⟨hal-01385203⟩
  • Eric Robert, Xavier Damany, Sylvain Iséni, Marc Vandamme, Sébastien Dozias, et al.. Bio environmental applications of plasmas . Frontiers in Plasma Science 2, Feb 2016, Greifswald, Germany. ⟨hal-01344069⟩
  • Simona Manta, Anthony Delalande, Gilles Renault, Michel Francis Bureau, Matthias Lebertre, et al.. Positively charged microbubbles to target nucleic acid delivery with ultrasound. Journées RITS 2015, Mar 2015, Dourdan, France. ⟨inserm-01154976⟩
  • Spiros Kotopoulis, Anthony Delalande, Chantal Pichon, Michiel Postema. Nonlinear microbubble behaviour for enhanced drug uptake. 19th International Congress on Sound and Vibration, Vilnius, Lithuania, July 8–12, 2012, Jul 2012, Vilnius, Lithuania. pp.685. ⟨hal-03195601⟩
  • Spiros Kotopoulis, Anthony Delalande, Chantal Pichon, Michiel Postema. Real-time sonoporation through HeLa cells. 19th International Symposium on Nonlinear Acoustics, Sep 2012, Tokyo, Japan. pp.271-274. ⟨hal-02128171⟩
  • Anthony Delalande, Spiros Kotopoulis, Patrick Midoux, Michiel Postema, Chantal Pichon. Ultrasound and microbubble-assisted gene delivery: insights for intracellular mechanism. Micro-acoustics in marine and medical research: 1st workshop, Dec 2011, Bergen, Norway. pp.119-130. ⟨hal-03197797⟩
  • Spiros Kotopoulis, Anthony Delalande, Chantal Pichon, Michiel Postema. Biological and medical applications of low-intensity ultrasound. Micro-acoustics in marine and medical research: 1st workshop, Dec 2011, Bergen, Norway. pp.67-105. ⟨hal-03197807⟩
  • Spiros Kotopoulis, Anthony Delalande, Chantal Pichon, Michiel Postema. On cells and sound. 34th Scandinavian Symposium on Physical Acoustics, 2011, Geilo, Norway. ⟨hal-03189343⟩
  • Anthony Delalande, Spiros Kotopoulis, Chantal Pichon, Michiel Postema. Cancer cell sonoporation at low acoustic amplitudes. 18th International Congress on Sound and Vibration, Rio de Janeiro, Brazil, 10-14 July 2011, Jul 2011, Rio de Janeiro, Brazil. pp.1695-1702. ⟨hal-03195599⟩
  • Anthony Delalande, Patrick Midoux, Chantal Pichon, Spiros Kotopoulis, Michiel Postema. Investigations of microbubble-cell interactions during the sonoporation process. 18th International Congress on Sound and Vibration, Rio de Janeiro, Brazil, 10-14 July 2011, Jul 2011, Rio de Janeiro, Brazil. ⟨hal-03195597⟩
  • Anthony Delalande, Ayache Bouakaz, Patrick Midoux, Michiel Postema, Chantal Pichon. Ultrasound-activated microbubbles for tendon gene transfer: in vivo efficiency and confocal microscopy real time intracellular investigations. 20th International Congress on Acoustics, ICA 2010, Aug 2010, Sidney, Australia. pp.524. ⟨hal-03195559⟩

Poster

  • M Clabaut, A. Boukerb, C. Pichon, A Suet, C Kremser, et al.. Estradiol effect on vaginal Lactobacillus crispatus. FEMS 2019, 8th Congress of European Microbiologists, Jul 2019, Glasgow, United Kingdom. ⟨hal-02383997v1⟩
  • Vinodini Vijayarangan, Anthony Delalande, Sébastien Dozias, Jean-Michel Pouvesle, Robert Eric, et al.. Cell Permeabilization and Molecular Delivery Following Helium Plasma jet Treatments. IMPCS1, Nov 2019, Orléans, France. ⟨hal-03090356⟩
  • Marlène Dezest, Vinodini Vijayarangan, Anthony Delalande, Chantal Pichon, Sylvain Iséni, et al.. Cell Response to He, He-O2 Plasma and Plasma Electric Field Alone Treatments. ICPM6, Sep 2016, Bratislava, Slovakia. ⟨hal-01948526⟩
  • E. Robert, X. Damany, S. Iseni, M. Vandamme, S. Dozias, et al.. Bio environmental applications of plasmas. Frontiers in Plasma Science 2, Feb 2016, Greifswald, Germany. ⟨hal-02986211⟩
  • Solenne Bire, Yves Bigot, N. Mermod, C. Pichon, O. Hérault, et al.. Contrôle et biosécurité de l'intégration d'un transgène médiés par l'ARNm de la transposase piggyBac et la présence de séquences insulatrices. Congrès 2012 de la Société Française d'Hématologie, Mar 2012, Paris, France. 1 p., 2012. ⟨hal-02809452⟩
  • Solenne Bire, Yves Bigot, N. Mermod, C. Pichon, F. Rouleux-Bonnin. Cytoplasmic transposase RNA transfer and insulated transgenes for safe and efficient trangenesis. CliniGene Meeting, Apr 2011, Paris, France. 2011. ⟨hal-02802483⟩

Chapitre d'ouvrage

  • F Perche, K Miyata. Hypoxia-Responsive Nanomedicines. Lin Zhu. Stimuli-Responsive Nanomedicine, Jenny Stanford Publishing, Chap. 5, 2020, ISBN 9789814800709. ⟨hal-02974284⟩
  • Magdalena Wytrwal, Chantal Pichon. Polyallylamine Derivatives: Novel NonToxic Transfection Agents. Methods in molecular biology, pp.159-174, 2016, ⟨10.1007/978-1-4939-3718-9_10⟩. ⟨hal-02071774⟩
  • Chantal Pichon, Patrick Midoux. Mannosylated and Histidylated LPR Technology for Vaccination with Tumor Antigen mRNA. Synthetic Messenger RNA and Cell Metabolism Modulation, pp.247-274, 2013, ⟨10.1007/978-1-62703-260-5_16⟩. ⟨hal-02070913⟩
  • P. Midoux, E. Lecam, D. Coulaud, E. Delain, C. Pichon. Histidine containing peptides and polypeptides as nucleic acid vectors. Luo D., Saltzman W.M. Synthetic DNA Delivery Systems, Kluwer Academic/Plenum Publishers, New-York, pp.23-44, 2003. ⟨hal-00115810⟩
  • M. Monsigny, C. Quétard, E. Duverger, C. Pichon, V. Altemayer, et al.. Glycoconjugates as vectors for gene and oligonucleotide delivery. Aubery M. Glycans in cellular interaction and recognition: therapeutic, Harwood Academic Publishers, Amsterdam, pp.193-215, 2002. ⟨hal-00115807⟩
  • P. Midoux, C. Pichon. Histidylated polycationic molecules for nucleic acids transfer. Pandalai S.G. Recent research developments in bioconjugate chemistry, Transworld Research Network, Trivandrum, pp.95-111, 2002. ⟨hal-00115805⟩
  • P. Midoux, C. Pichon. Peptide-based gene delivery systems. Mahato R.I., Kim S.W. Pharmaceutical perspectives of nucleic acid-based, Taylor & Francis, London and New York, pp.334-366, 2002. ⟨hal-00115804⟩
  • Jean-Marc Malinge, Marc Leng. Interstrand Cross-Links in Cisplatin- or Transplatin-Modified DNA. Cisplatin: Chemistry and Biochemistry of a Leading Anticancer Drug, Verlag Helvetica Chimica Acta, pp.159-180, 1999, 783906390208. ⟨hal-02173052⟩
  • M. Monsigny, A.-C. Roche, P. Midoux, R. Mayer. Sugar Specific Delivery of Drugs, Oligonucleotides and Genes. Targeting of drugs4, Springer US, pp.31-50, 1994, 978-1-4899-1209-1. ⟨hal-02163778⟩
  • P. Midoux, A.C Roche, M. Monsigny. Endocytosis Analysis by Flow Cytometry : Study of the Endocytosis of Fluoresceinylated Neoglycoproteins Via Membrane Lectins of Macrophages. Flow cytometry NATO ASI Series, 67, Springer Berlin Heidelberg, pp.49-64, 1993. ⟨hal-02163788⟩
  • Michel Monsigny, Annie-Claude Roche, Roger Mayer, Patrick Midoux, Eric Negre, et al.. Glycosylated Polymers as Carriers for Targeting Antiviral and Antiparasite Drugs. Endocytosis - NATO ASI Series, 62, Springer Berlin Heidelberg, pp.489-496, 1992. ⟨hal-02163791⟩
  • Frederic Gaucheron, Marie-Agnes Lemaire, Jean-Marc Malinge, Annie Schwartz, Marc Leng. Reactivity of DNA and cis-Diamminedichloroplatinumul(II) in the Presence of Intercalating Agents. Platinum and Other Metal Coordination Compounds in Cancer Chemotherapy, Springer US, pp.73-79, 1991, 978-1-4899-0740-0. ⟨hal-02134699⟩
  • M. Monsigny, A.C Roche, C. Kieda, R. Mayer, P. Midoux. Peptide and Carbohydrate Moieties as Molecular Signals in Animal Cell Recognition. Cell to Cell Signals in Plant, Animal and Microbial Symbiosis, Springer Berlin Heidelberg, pp.237-254, 1988. ⟨hal-02163831⟩
  • J.-Ph Grivet, P. Midoux, P. Gatellier, F. Delmotte, M. Monsigny. Wheat Germ Agglutinin: A Review of Recent Results. Structure, Dynamics, Interactions and Evolution of Biological Macromolecules, Springer Netherlands, pp.329-349, 1983. ⟨hal-02163840⟩

Direction d'ouvrage, Proceedings

  • Alain Bruhat, Cedric Chaveroux, Valerie Carraro, Celine Jousse, Julien Averous, et al.. Regulating the expression of therapeutic transgenes by controlled intake of dietary essential amino acids. European Society of Gene and Cell Therapy (ESCGT) Congress, Oct 2017, Berlin, Germany. 28 (12), Mary Ann Liebert, pp.A61-A61, 2017, Human Gene Therapy, ⟨10.1089/hum.2017.29055.abstracts⟩. ⟨hal-02786230⟩

Brevet

  • Jean-Marc Malinge, Patrick Midoux, Thomas Thibault, Chantal Pichon. In vitro production of DNA minicircles less than 250 base pairs. France, Patent n° : EP2735614A1. 2014. ⟨hal-02134791⟩

Pré-publication, Document de travail

  • Shubaash Anthiya, Audrey Griveau, Claire Loussouarn, Patrick Baril, Martin Garnett, et al.. MicroRNA-based therapeutics and nanomedicine for brain tumour treatment. 2019. ⟨inserm-02178906⟩

Thèse

  • Anthony Delalande. Méthodes de transfert de gènes non virales : application aux pathologies tendineuses. Sciences agricoles. Université d'Orléans, 2011. Français. ⟨NNT : 2011ORLE2076⟩. ⟨tel-01128057⟩
  • Federico Perche. Transfert d'ARNm par des lipopolyplexes et vaccination antimélanome : ciblage des cellules dendritiques à l'aide de lipopolyplexes mannosylés. Médecine humaine et pathologie. Université d'Orléans, 2010. Français. ⟨NNT : 2010ORLE2068⟩. ⟨tel-00665118⟩