CHARPENTIER Stéphane

email : stephane.charpentier[remplacer_par_at]cnrs-orleans.fr

Téléphone : 02.38.25.55.96

Maître de conférence au sein du groupe thématique “Apoptose et autophagie normales et pathologiques”

 



18 documents

Article dans une revue

  • Amandine Serrano, Saïd El Haddad, Fréderic Moal, Thierry Prazuck, Eric Legac, et al.. Dysregulation of apoptosis and autophagy gene expression in peripheral blood mononuclear cells of efficiently treated HIV-infected patients. AIDS, Lippincott, Williams & Wilkins, 2018, 32 (12), pp.1579 - 1587. ⟨10.1097/QAD.0000000000001851⟩. ⟨hal-01936094⟩
  • Saïd El Haddad, Amandine Serrano, Thierry Normand, Chloé Robin, Martine Dubois, et al.. Interaction of Alpha-synuclein with Cytogaligin, a protein encoded by the proapoptotic gene GALIG. Biochemical and Biophysical Research Communications, Elsevier, 2018, 495 (1), pp.787-792. ⟨10.1016/j.bbrc.2017.11.078⟩. ⟨hal-01966108⟩
  • Lucile Mollet, Pauline Robinet, Martine Dubois, Axel Aurouet, Thierry Normand, et al.. Opposing Mcl-1, the GALIG proapoptotic gene is upregulated as neutrophils die and underexpressed in Acute Myeloid Leukemia cells.. Molecular Immunology, Elsevier, 2013, 56 (1-2), pp.123-8. ⟨10.1016/j.molimm.2013.04.012⟩. ⟨hal-00840170⟩
  • Pauline Robinet, Lucile Mollet, Patrick Gonzalez, Thierry Normand, Stephane Charpentier, et al.. The mitogaligin protein is addressed to the nucleus via a non-classical localization signal. Biochemical and Biophysical Research Communications, Elsevier, 2010, 392 (1), pp.53-57. ⟨10.1016/j.bbrc.2009.12.162⟩. ⟨hal-00529397⟩
  • Alexis D. Sennepin, Stéphane Charpentier, Thierry Normand, Cedric Sarre, Alain Legrand, et al.. Multiple reprobing of Western blots after inactivation of peroxidase activity by its substrate, hydrogen peroxide. Analytical Biochemistry, Elsevier Masson, 2009, 393 (1), pp.129-131. ⟨10.1016/j.ab.2009.06.004⟩. ⟨hal-00525339⟩
  • Patrick Gonzalez, Pauline Robinet, Stéphane Charpentier, Lucile Mollet, Thierry Normand, et al.. Apoptotic activity of a nuclear form of mitogaligin, a cell death protein. Biochemical and Biophysical Research Communications, Elsevier, 2009, 378 (4), pp.816-820. ⟨10.1016/j.bbrc.2008.11.133⟩. ⟨hal-00522444⟩
  • Patrick Gonzalez, Mélanie Duneau, Stéphane Charpentier, Thierry Normand, Lucile Mollet, et al.. Destabilization of Membranes Containing Cardiolipin or Its Precursors by Peptides Derived from Mitogaligin, a Cell Death Protein. Biochemistry, American Chemical Society, 2007, 46 (25), pp.7374-7382. ⟨10.1021/bi700213p⟩. ⟨hal-00159568⟩
  • M. Duneau, M. Boyer Guittaut, P. Gonzalez, S. Charpentier, T. Normand, et al.. Galig, a novel cell death gene that encodes a mitochondrial protein promoting cytochrome c release. Experimental Cell Research, Elsevier, 2005, 302, pp.194-205. ⟨hal-00088588⟩
  • Michaël Guittaut, Stéphane Charpentier, Thierry Normand, Martine Dubois, Jacques Raimond, et al.. Identification of an Internal Gene to the Human Galectin-3 Gene with Two Different Overlapping Reading Frames That Do Not Encode Galectin-3. Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 2001, 276 (4), pp.2652-2657. ⟨10.1074/jbc.m002523200⟩. ⟨hal-02137994⟩
  • Stéphane Charpentier, Mohamed Amiche, Jan Mester, Véronique Vouille, Jean-Pierre Le Caer, et al.. Structure, Synthesis, and Molecular Cloning of Dermaseptins B, a Family of Skin Peptide Antibiotics. Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 1998, 273 (24), pp.14690-14697. ⟨10.1074/jbc.273.24.14690⟩. ⟨hal-02160836⟩
  • Stéphane Charpentier, Keith Jarvie, Diana Severynse, Marc Caron, Mario Tiberi. Silencing of the Constitutive Activity of the Dopamine D1B Receptor. Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 1996, 271 (45), pp.28071-28076. ⟨10.1074/jbc.271.45.28071⟩. ⟨hal-02160838⟩
  • Stéphane Charpentier, S. Sagan, M Naim, A Delfour, P. Nicolas. Mechanism of delta-opioid receptor selection by the address domain of dermenkephalin.. European Journal of Pharmacology, Elsevier, 1994, 266 (2), pp.175-80. ⟨10.1016/0922-4106(94)90107-4⟩. ⟨hal-02160840⟩
  • Mohamed Naim, Stéphane Charpentier, Pierre Nicolas, Daniel Baron. Quantitative two-dimensional nmr study of dermenkephalin, a highly potent and selective ?-opioid peptide. Biopolymers, Wiley, 1993, 33 (12), pp.1889-1900. ⟨10.1002/bip.360331214⟩. ⟨hal-02160842⟩
  • S Sagan, Stéphane Charpentier, M Naim, A Delfour, P Nicolas. Opioid peptides from amphibian skin: contribution of the amino acids of the "address" domain to the -selectivity of dermenkephalin. Peptides, Elsevier, 1992, pp.645-646. ⟨hal-02171902⟩
  • Sandrine Sagan, Stéphane Charpentier, Antoine Delfour, Mohamed Amiche, Pierre Nicolas. The aspartic acid in deltorphin I and dermenkephalin promotes targeting to δ-opioid receptor independently of receptor binding. Biochemical and Biophysical Research Communications, Elsevier, 1992, 187 (3), pp.1203-1210. ⟨10.1016/0006-291X(92)90431-J⟩. ⟨hal-02171853⟩
  • P Simon, Stéphane Charpentier, J. Costentin. An automated method for the assessment of spontaneous and stereotyped climbing behavior in mice. Effects of the selective D1- and D2-dopamine receptor agonists SKF-38393 and RU-24926 and their association.. Methods and findings in experimental and clinical pharmacology, Prous Science, 1991, 13 (2), pp.99-104. ⟨hal-02171886⟩
  • Stéphane Charpentier, Sandrine Sagan, Antoine Delfour, Pierre Nicolas. Dermenkephalin and deltorphin I reveal similarities within ligand-binding domains of μ- and δ-opioid receptors and an additional address subsite on the δ-receptor. Biochemical and Biophysical Research Communications, Elsevier, 1991, 179 (3), pp.1161-1168. ⟨10.1016/0006-291x(91)91693-7⟩. ⟨hal-02171883⟩
  • Jean Bralet, Claude Mossiat, Jeanne-Marie Lecomte, Stéphane Charpentier, Claude Gros, et al.. Diuretic and natriuretic responses in rats treated with enkephalinase inhibitors. European Journal of Pharmacology, Elsevier, 1990, 179 (1-2), pp.57-64. ⟨10.1016/0014-2999(90)90401-q⟩. ⟨hal-02171891⟩

BUSCO Giovanni

email : giovanni.busco[remplacer_par_at]cnrs-orleans.fr

Téléphone : 02.38.25.55.59

Postdoctorant chercheur au sein du Groupe thématique “Microenvironnement cellulaire et pharmacologie des récepteurs”

 



25 documents

Article dans une revue

  • Anna Dzimitrowicz, Aleksandra Bielawska-Pohl, Piotr Jamroz, Jerzy Dora, Agnieszka Krawczenko, et al.. Activation of the Normal Human Skin Cells by a Portable Dielectric Barrier Discharge-Based Reaction-Discharge System of a Defined Gas Temperature. Plasma Chemistry and Plasma Processing, Springer Verlag, In press, ⟨10.1007/s11090-019-10039-0⟩. ⟨hal-02354478⟩
  • Giovanni Busco, Azadeh Valinataj Omran, Loick Ridou, Jean-Michel Pouvesle, Eric Robert, et al.. Cold atmospheric plasma-induced acidification of tissue surface: visualization and quantification using agarose gel models. Journal of Physics D: Applied Physics, IOP Publishing, 2019, 52 (24), pp.24LT01. ⟨10.1088/1361-6463/ab1119⟩. ⟨hal-02089383⟩
  • Giovanni Busco, Fabienne Fasani, Sébastien Dozias, Loick Ridou, Claire Douat, et al.. Changes in Oxygen Level Upon Cold Plasma Treatments: Consequences for RONS Production. IEEE Transactions on Radiation and Plasma Medical Sciences, IEEE, 2018, 2 (2), pp.147 - 152. ⟨10.1109/TRPMS.2017.2775705⟩. ⟨hal-01803848⟩
  • Maria Raffaella Greco, Ester Antelmi, Giovanni Busco, Lorenzo Guerra, Rosa Rubino, et al.. Protease activity at invadopodial focal digestive areas is dependent on NHE1-driven acidic pHe. Oncology Reports, Spandidos Publications, 2014, 31 (2), pp.940-946. ⟨10.3892/or.2013.2923⟩. ⟨hal-02263673⟩
  • Teresa Anna Giancaspero, Giovanni Busco, Concetta Panebianco, Claudia Carmone, Angelica Miccolis, et al.. FAD Synthesis and Degradation in the Nucleus Create a Local Flavin Cofactor Pool. Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 2013, 288 (40), pp.29069-29080. ⟨10.1074/jbc.M113.500066⟩. ⟨hal-02263674⟩
  • Antonio Cardone, Francesco Lopez, Francesco Affortunato, Giovanni Busco, Aldebaran Hofer, et al.. An aryleneethynylene fluorophore for cell membrane staining. Biochimica et Biophysica Acta:Biomembranes, Elsevier, 2012, 1818 (11), pp.2808-2817. ⟨10.1016/j.bbamem.2012.06.011⟩. ⟨hal-02263676⟩
  • Andrea Gerbino, Isabella Maiellaro, Claudia Carmone, Rosa Caroppo, Lucantonio Debellis, et al.. Glucose increases extracellular [Ca2+] in rat insulinoma (INS-1E) pseudoislets as measured with Ca2+-sensitive microelectrodes. Cell Calcium, Elsevier, 2012, 51 (5), pp.393-401. ⟨10.1016/j.ceca.2012.01.002⟩. ⟨hal-02263680⟩
  • Rosa Angela Cardone, Maria Raffaella Greco, Mattia Capulli, Edward Weinman, Giovanni Busco, et al.. NHERF1 acts as a molecular switch to program metastatic behavior and organotropism via its PDZ domains. Molecular Biology of the Cell, American Society for Cell Biology, 2012, 23 (11), pp.2028-2040. ⟨10.1091/mbc.e11-11-0911⟩. ⟨hal-02263678⟩
  • Giovanni Busco, Rosa Cardone, Maria Greco, Giovanni Bellizzi, Matilde Colella, et al.. NHE1 promotes invadopodial ECM proteolysis through acidification of the peri-invadopodial space. FASEB Journal, Federation of American Society of Experimental Biology, 2010, 24 (10), pp.3903-3915. ⟨10.1096/fj.09-149518⟩. ⟨hal-02263657⟩
  • Rosa Cardone, Antonia Bellizzi, Giovanni Busco, Edward Weinman, Maria Dell'Aquila, et al.. The NHERF1 PDZ2 Domain Regulates PKA–RhoA–p38-mediated NHE1 Activation and Invasion in Breast Tumor Cells. Molecular Biology of the Cell, American Society for Cell Biology, 2007, 18 (5), pp.1768-1780. ⟨10.1091/mbc.e06-07-0617⟩. ⟨hal-02263661⟩
  • Rosa Cardone, Anna Bagorda, Antonia Bellizzi, Giovanni Busco, Lorenzo Guerra, et al.. Protein Kinase A Gating of a Pseudopodial-located RhoA/ROCK/p38/NHE1 Signal Module Regulates Invasion in Breast Cancer Cell Lines. Molecular Biology of the Cell, American Society for Cell Biology, 2005, 16 (7), pp.3117-3127. ⟨10.1091/mbc.e04-10-0945⟩. ⟨hal-02263664⟩
  • Lorenzo Guerra, Teresa Fanelli, Maria Favia, Stefania Riccardi, Giovanni Busco, et al.. Na + /H + Exchanger Regulatory Factor Isoform 1 Overexpression Modulates Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Expression and Activity in Human Airway 16HBE14o- Cells and Rescues ΔF508 CFTR Functional Expression in Cystic Fibrosis Cells. Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 2005, 280 (49), pp.40925-40933. ⟨10.1074/jbc.M505103200⟩. ⟨hal-02263667⟩

Communication dans un congrès

  • Giovanni Busco, Azadeh Valinataj Omran, Loick Ridou, Jean-Michel Pouvesle, Robert Eric, et al.. A fluorescent method to measure plasma-induced surface acidification on tissue models. Journées Happybio 2019, Nov 2019, Nouan Le Fuzelier, France. ⟨hal-02463782⟩
  • Giovanni Busco, Loick Ridou, Fabienne Fasani, Sébastien Dozias, Jean-Michel Pouvesle, et al.. Investigation on a He-Plasma Gun source for cosmetic purposes: the importance of skin microenvironment. ICPM7, ISPM, Jun 2018, Philadelphia, United States. ⟨hal-01943058⟩
  • Giovanni Busco, Fabienne Fasani, Sébastien Dozias, Loick Ridou, Claire Douat, et al.. Importance de la pression partielle d’oxygène lors des traitements par le plasma froid. Journées du GDR ABioPlas, GDR ABioPlas, Oct 2017, Paris, France. ⟨hal-01945949⟩
  • Eric Robert, Giovanni Busco, Catherine Grillon, Jean-Michel Pouvesle. Potential of low temperature atmospheric pressure plasma sources in cosmetic. COSMINNOV 2016, Cosmetic Valley, May 2016, Orléans, France. ⟨hal-01340267⟩
  • Jean-Michel Pouvesle, Thibault Darny, Sylvain Iséni, Xavier Damany, Giovanni Busco, et al.. Jets de plasmas atmosphériques pour des applications thérapeutiques de la décharge aux traitements: études, problèmes et enjeux . SFP PLASMA, SFP PLasma, Jun 2016, Nancy, France. ⟨hal-01340280⟩
  • Giovanni Busco, Fabienne Fasani, Claire Douat, Sebastien Dozias, Jean-Michel Pouvesle, et al.. Study of Chemico-Physical Properties of a He Plasma Gun in the Context of Skin Physioxia for Cosmetical Applications. 6th International Conference on Plasma Medicine (ICPM-6), Sep 2016, Bratislava, Slovakia. ⟨hal-01620850⟩
  • Claire Douat, Giovanni Busco, Vini Vijayarangan, Sebastien Dozias, Sylvain Iséni, et al.. Challenges in the transition from in vitro to in vivo experiments: source effects and biological aspects. IWPCT3, Apr 2016, Washington, United States. ⟨hal-01340223⟩

Poster

  • Giovanni Busco, Azadeh Valinataj Omran, Loick Ridou, Jean-Michel Pouvesle, Eric Robert, et al.. Fluorescein-agarose gel as a tissue model to visualize and measure local CAP-induced acidification. 24th International Symposium on Plasma Chemistry (ISPC24), Jun 2019, Naples, Italy. ⟨hal-02263357⟩
  • Azadeh Omran, Giovanni Busco, Sébastien Dozias, C. Grillon, Jean-Michel Pouvesle, et al.. Distribution and penetration of reactive oxygen and nitrogen species through a tissue phantom after Plasma Gun treatment. 24th International Symposium on Plasma Chemistry (ISPC24),, Jun 2019, Naples, Italy. ⟨hal-02263879⟩
  • Giovanni Busco, Claire Douat, Fabienne Fasani, Sébastien Dozias, Jean-Michel Pouvesle, et al.. Changes in oxygen level upon plasma treatments : consequences for RONS production?. 4th International Workshop on Plasma for CancerTreatment (IWPCT–2017), Mar 2017, Paris, France. ⟨hal-02453420⟩
  • J van der Paal, S Heijkers, J Slaets, G Busco, E Robert, et al.. Chemical kinetics model for hypoxia effect in the afterglow of an argon plasma jet. 23rd International Symposium on Plasma Chemistry (ISPC23), Jul 2017, Montréal, Canada. ⟨hal-01620809⟩
  • G Busco, F Fasani, C Douat, S. Dozias, Jm Pouvesle, et al.. Properties of a He Plasma Gun in the Context of Skin Physioxia for Cosmetical Applications. GDR 3374 AbioPlas, Applications Biomédicales des Plasmas, Nov 2016, Albi, France. ⟨hal-02453409⟩
  • Giovanni Busco, Fabienne Fasani, Claire Douat, Sébastien Dozias, Jean-Michel Pouvesle, et al.. Study of Chemico-Physical Properties of a He Plasma Gun in the Context of Skin Physioxia for Cosmetical Applications. Journées du GDR ABioPlas, Nov 2016, Albi, France. ⟨hal-01945786⟩

BRULÉ-MORABITO Fabienne

email : fabienne.brule[remplacer_par_at]cnrs-orleans.fr

Téléphone : 02.38.25.55.86

Maître de conférences au sein du groupe thématique “Apoptose et autophagie normales et pathologiques”

 



7 documents

Article dans une revue

  • Saïd El Haddad, Amandine Serrano, Fréderic Moal, Thierry Normand, Chloé Robin, et al.. Disturbed expression of autophagy genes in blood of Parkinson’s disease patients. Gene, Elsevier, 2020, 738, pp.144454. ⟨10.1016/j.gene.2020.144454⟩. ⟨hal-02501027⟩
  • Adrien Blisnick, Ladislav Šimo, Catherine Grillon, Fabienne Fasani, Sébastien Brûlé, et al.. The Immunomodulatory Effect of IrSPI, a Tick Salivary Gland Serine Protease Inhibitor Involved in Ixodes ricinus Tick Feeding. Vaccines, MDPI, 2019, 7 (4), pp.E148. ⟨10.3390/vaccines7040148⟩. ⟨hal-02354425⟩
  • Amandine Serrano, Saïd El Haddad, Fréderic Moal, Thierry Prazuck, Eric Legac, et al.. Dysregulation of apoptosis and autophagy gene expression in peripheral blood mononuclear cells of efficiently treated HIV-infected patients. AIDS, Lippincott, Williams & Wilkins, 2018, 32 (12), pp.1579 - 1587. ⟨10.1097/QAD.0000000000001851⟩. ⟨hal-01936094⟩
  • Saïd El Haddad, Amandine Serrano, Thierry Normand, Chloé Robin, Martine Dubois, et al.. Interaction of Alpha-synuclein with Cytogaligin, a protein encoded by the proapoptotic gene GALIG. Biochemical and Biophysical Research Communications, Elsevier, 2018, 495 (1), pp.787-792. ⟨10.1016/j.bbrc.2017.11.078⟩. ⟨hal-01966108⟩
  • Lucile Mollet, Pauline Robinet, Martine Dubois, Axel Aurouet, Thierry Normand, et al.. Opposing Mcl-1, the GALIG proapoptotic gene is upregulated as neutrophils die and underexpressed in Acute Myeloid Leukemia cells.. Molecular Immunology, Elsevier, 2013, 56 (1-2), pp.123-8. ⟨10.1016/j.molimm.2013.04.012⟩. ⟨hal-00840170⟩
  • Pauline Robinet, Lucile Mollet, Patrick Gonzalez, Thierry Normand, Stephane Charpentier, et al.. The mitogaligin protein is addressed to the nucleus via a non-classical localization signal. Biochemical and Biophysical Research Communications, Elsevier, 2010, 392 (1), pp.53-57. ⟨10.1016/j.bbrc.2009.12.162⟩. ⟨hal-00529397⟩
  • F. Kieken, F. Paquet, F. BrulÉ, J. Paoletti, G. Lancelot. A new NMR solution structure of the SL1 HIV-1Lai loop-loop dimmer. Nucleic Acids Research, Oxford University Press, 2006, 34, pp.343-352. ⟨10.1093/nar/gkj427⟩. ⟨hal-00088868⟩

BÉNÉDETTI Hélène

email : helene.benedetti[remplacer_par_at]cnrs-orleans.fr

Téléphone : 02.38.25.55.84

Directrice de recherche, co-coordinatrice de l’équipe “Biologie cellulaire, cibles moléculaires et thérapies innovantes” et co-Responsable du groupe thématique “Signalisation cellulaire et neurofibromatose”

 



74 documents

Article dans une revue

  • Béatrice Vallée, Michel Doudeau, Fabienne Godin, Hélène Bénédetti. Characterization at the Molecular Level using Robust Biochemical Approaches of a New Kinase Protein. Journal of visualized experiments : JoVE, JoVE, 2019, pp.e59820. ⟨10.3791/59820⟩. ⟨hal-02282630⟩
  • Julie Tastet, Hélène Cuberos, Béatrice Vallée, Annick Toutain, Martine Raynaud, et al.. LIMK2-1 is a Hominidae-Specific Isoform of LIMK2 Expressed in Central Nervous System and Associated with Intellectual Disability. Neuroscience, Elsevier - International Brain Research Organization, 2019, 399, pp.199-210. ⟨10.1016/j.neuroscience.2018.12.017⟩. ⟨hal-02067472⟩
  • Béatrice Vallée, Hélène Cuberos, Michel Doudeau, Fabienne Godin, David Gosset, et al.. LIMK2-1, a new isoform of human LIMK2, regulates actin cytoskeleton remodeling via a different signaling pathway than that of its two homologs, LIMK2a and LIMK2b. Biochemical Journal, Portland Press, 2018, 475 (23), pp.3745-3761. ⟨hal-01966439⟩
  • Viorel Simion, Wissem Deraredj Nadim, Hélène Bénédetti, Chantal Pichon, Séverine Morisset-Lopez, et al.. Pharmacomodulation of microRNA Expression in Neurocognitive Diseases: Obstacles and Future Opportunities. Current Neuropharmacology, Bentham Science Publishers, 2017, 15 (2), pp.276 - 290. ⟨10.2174/1570159X14666160630210422⟩. ⟨hal-01618771⟩
  • Wissem Deraredj Nadim, Simion Viorel, Hélène Bénédetti, Chantal Pichon, Patrick Baril, et al.. MicroRNAs in Neurocognitive Dysfunctions: New Molecular Targets for Pharmacological Treatments?. Current Neuropharmacology, Bentham Science Publishers, 2017, 15 (2), pp.260 - 275. ⟨10.2174/1570159X14666160709001441⟩. ⟨hal-01618199⟩
  • Wissem Deraredj Nadim, Séverine Chaumont-Dubel, Fahima Madouri, Laetitia Cobret, Marie-Ludivine de Tauzia, et al.. Physical interaction between neurofibromin and serotonin 5-HT 6 receptor promotes receptor constitutive activity. Proceedings of the National Academy of Sciences of the United States of America , National Academy of Sciences, 2016, 113 (43), pp.12310 - 12315. ⟨10.1073/pnas.1600914113⟩. ⟨hal-01407899⟩
  • L Cobret, M L de Tauzia, J Ferent, E Traiffort, I Hénaoui, et al.. Targeting the cis-dimerization of LINGO-1 with low MW compounds affects its downstream signalling. British Journal of Clinical Pharmacology, Wiley, 2015, 172 (3), pp.841-856. ⟨10.1111/bph.12945⟩. ⟨hal-01170735⟩
  • Julie Tastet, Loïc Decalonne, Sylviane Marouillat, Joëlle Malvy, Rose-Anne Thépault, et al.. Mutation screening of the ubiquitin ligase gene RNF135 in French patients with autism. Psychiatric Genetics, Lippincott, Williams & Wilkins, 2015, 25 (6), pp.263-267. ⟨10.1097/ypg.0000000000000100⟩. ⟨hal-02072312⟩
  • H. Cuberos, B. VallÉe, P. Vourc'H, J. Tastet, C.R. Andres, et al.. Roles of LIM kinases in central nervous system function and dysfunction. FEBS Letters, Wiley, 2015, 589 (24PartB), pp.3795-3806. ⟨10.1016/j.febslet.2015.10.032⟩. ⟨hal-02072231⟩
  • Solene Guiheneuf, Ludovic Paquin, Francois Carreaux, Emilie Durieu, Helene Benedetti, et al.. Microwave Assisted Organic Synthesis (MAOS) of New Dispacamide A Derivatives Bearing a Thiazolinone Platform, Biological Assays on Inhibition of Protein Kinases and Cell Effects. Current microwave chemistry, 2014, 1 (1), pp.33-40. ⟨10.2174/22133356114019990002⟩. ⟨hal-01114583⟩
  • Reine Nehmé, Hala Nehmé, Thibault Saurat, Marie-Ludivine De-Tauzia, Frédéric Buron, et al.. New in-capillary electrophoretic kinase assays to evaluate inhibitors of the PI3k/Akt/mTOR signaling pathway.. Analytical and Bioanalytical Chemistry, Springer Verlag, 2014, 406 (15), pp.3743-3754. ⟨hal-01180770⟩
  • Thibault Saurat, Frédéric Buron, Nuno Rodrigues, Marie-Ludivine de Tauzia, Lionel Colliandre, et al.. Design, Synthesis, and Biological Activity of Pyridopyrimidine Scaffolds as Novel PI3K/mTOR Dual Inhibitors. Journal of Medicinal Chemistry, American Chemical Society, 2014, 57 (3), pp.613-631. ⟨10.1021/jm401138v⟩. ⟨hal-01180887⟩
  • Amélie Bruel, Romain Bénéteau, Mylène Chabanne, Olivier Lozach, Rémy Le Guevel, et al.. Synthesis of new pyridazino[4,5-b]indol-4-ones and pyridazin-3(2H)-one analogs as DYRK1A inhibitors. Bioorganic and Medicinal Chemistry Letters, Elsevier, 2014, 24 (21), pp.5037 - 5040. ⟨10.1016/j.bmcl.2014.09.017⟩. ⟨hal-01086026⟩
  • François Hericourt, François Chefdor, Lucie Bertheau, Mirai Tanigawa, Tatsuya Maeda, et al.. Characterization of histidine-aspartate kinase HK1 and identification of histidine phosphotransfer proteins as potential partners in a Populus multistep phosphorelay. Physiologia Plantarum, Wiley, 2013, 149 (2), pp.188-199. ⟨10.1111/ppl.12024⟩. ⟨hal-02070851⟩
  • Julie Tastet, Patrick Vourc'H, Frédéric Laumonnier, Béatrice Vallée, Carole Michelle, et al.. LIMK2d, a truncated isoform of Lim kinase 2 regulates neurite growth in absence of the LIM kinase domain. Biochemical and Biophysical Research Communications, Elsevier, 2012, 420 (2), pp.247-252. ⟨10.1016/j.bbrc.2012.02.134⟩. ⟨hal-01136281⟩
  • Béatrice Vallée, Michel Doudeau, Fabienne Godin, Aurélie Gombault, Aurélie Tchalikian, et al.. Nf1 RasGAP inhibition of LIMK2 mediates a new cross-talk between Ras and Rho pathways.. PLoS ONE, Public Library of Science, 2012, 7 (10), pp.e47283. ⟨10.1371/journal.pone.0047283⟩. ⟨hal-00817355⟩
  • Martine Beaufour, Fabienne Godin, Béatrice Vallée, Martine Cadene, Hélène Bénédetti. Interaction Proteomics Suggests a New Role for the Tfs1 Protein in Yeast.. Journal of Proteome Research, American Chemical Society, 2012, 11 (6), pp.3211-3218. ⟨10.1021/pr201239t⟩. ⟨hal-00721771⟩
  • Dominique Arnaud, Annabelle Déjardin, Jean-Charles Leplé, Marie-Claude Lesage-Descauses, Nathalie Boizot, et al.. Expression analysis of LIM gene family in poplar, toward an updated phylogenetic classification.. BMC Research Notes, BioMed Central, 2012, 5, pp.102. ⟨10.1186/1756-0500-5-102⟩. ⟨hal-00721759⟩
  • Fabienne Godin, Sandrine Villette, Béatrice Vallée, Michel Doudeau, Séverine Morisset-Lopez, et al.. A fraction of neurofibromin interacts with PML bodies in the nucleus of the CCF astrocytoma cell line.. Biochemical and Biophysical Research Communications, Elsevier, 2012, 418 (4), pp.689-94. ⟨10.1016/j.bbrc.2012.01.079⟩. ⟨hal-00721861⟩
  • A. Bruel, Cedric Logé, M.-L. de Tauzia, M. Ravache, Ronan Le Guével, et al.. Synthesis and biological evaluation of new 5-benzylated 4-oxo-3,4-dihydro-5Hpyridazino[4,5-b]indoles as PI3Ka inhibitors.. European Journal of Medicinal Chemistry, Elsevier, 2012, 57, pp.225-233. ⟨hal-00764872⟩
  • Aurélie Gombault, Jonas Warringer, Robert Caesar, Fabienne Godin, Béatrice Vallée, et al.. A phenotypic study of TFS1 mutants differentially altered in the inhibition of Ira2p or CPY. FEMS Yeast Research, Oxford University Press (OUP), 2009, 9 (6), pp.867-874. ⟨10.1111/j.1567-1364.2009.00535.x⟩. ⟨hal-00522432⟩
  • Aurélie Gombault, Fabienne Godin, Denise Sy, Baptiste Legrand, Hélène Chautard, et al.. Molecular Basis of the Tfs1/Ira2 Interaction: A Combined Protein Engineering and Molecular Modelling Study. Journal of Molecular Biology, Elsevier, 2007, 374 (3), pp.604-617. ⟨10.1016/j.jmb.2007.09.057⟩. ⟨hal-00181161⟩
  • F. Chefdor, H. BÉnÉdetti, C. Depierreux, Franck Delmotte, D. Morabito, et al.. Osmotic stress sensing in Populus: components identification of a phosphorelay system. FEBS Letters, Wiley, 2006, 580 (1), pp.77-81. ⟨10.1016/j.febslet.2005.11.051⟩. ⟨hal-00088838⟩
  • S. Quevillon-Cheruel, N. Leulliot, M. Graille, N. Hervouet, F. Coste, et al.. Crystal structure of yeast YHR049W/FSH1, a member of the serine hydrolase family. Protein science : a publication of the Protein Society., 2005, 14, pp.1350-1356. ⟨hal-00088667⟩
  • S. Castella, Hélène Bénédetti, R. de Llorens, J.L. Dacheux, F. Dacheux. Train A, an RNase-A-like protein without RNase activity is secreted and reabsorbed by the same epididymal cells under testicular control. Biology of Reproduction, Society for the Study of Reproduction, 2004, 71 (5), pp.1677-1687. ⟨10.1095/biolreprod.104.031666⟩. ⟨hal-00112960⟩
  • H. Chautard, M. Jacquer, F. Schoentgen, N. Bureaud, H. BÉnÉdetti. Tfs1, a member of the PEBP family, inhibits the Ira2p but not the Ira1p Ras GTPase activating protein in Saccharomyces cerevisiae. Eukaryotic Cell, American Society for Microbiology, 2004, 3 (2), pp.459-470. ⟨10.1128/EC.3.2.459-470.2004⟩. ⟨hal-00112967⟩
  • Sandrine Castella, H. BÉnÉdetti, R. de Llorens, J.L. Dacheux, Françoise Dacheux. Train A, an RNase A-Like Protein Without RNase Activity, Is Secreted and Reabsorbed by the Same Epididymal Cells under Testicular Control. Biology of Reproduction, Society for the Study of Reproduction, 2004, 71, pp.1677-1687. ⟨hal-02680403⟩
  • Emmanuelle Bouveret, Laure Journet, Anne Walburger, Eric Cascales, Hélène Bénédetti, et al.. Analysis of the Escherichia coli Tol-Pal and TonB systems by periplasmic production of Tol, TonB, colicin, or phage capsid soluble domains.. Biochimie, Elsevier, 2002, 84 (5-6), pp.413-21. ⟨hal-02130103⟩
  • Laurence Serre, F Serre, Charles Zelwer, Nicole Bureaud, Francoise Schoentgen, et al.. Crystal structures of YBHB and YBCL from Escherichia coli , two bacterial homologues to a Raf kinase inhibitor protein 1 1Edited by R. Huber. Journal of Molecular Biology, Elsevier, 2001, 310 (3), pp.617-634. ⟨10.1006/jmbi.2001.4784⟩. ⟨hal-02130120⟩
  • L. Journet, E. Bouveret, A. Rigal, R Lloubes, C Lazdunski, et al.. Import of colicins across the outer membrane of Escherichia coli involves multiple protein interactions in the periplasm.. Molecular Microbiology, Wiley, 2001, 42 (2), pp.331-44. ⟨hal-02130124⟩
  • C. Lazdunski, E. Bouveret, A Rigal, L. Journet, R. Lloubes, et al.. Colicin import into Escherichia coli cells requires the proximity of the inner and outer membranes and other factors. International Journal of Medical Microbiology, Elsevier, 2000, 290 (4-5), pp.337-344. ⟨10.1016/S1438-4221(00)80037-5⟩. ⟨hal-02130686⟩
  • E Bouveret, H Bénédetti, A Rigal, E. Loret, C Lazdunski. In vitro characterization of peptidoglycan-associated lipoprotein (PAL)-peptidoglycan and PAL-TolB interactions.. Journal of Bacteriology, American Society for Microbiology, 1999, 181 (20), pp.6306-11. ⟨hal-02130134⟩
  • Laure Journet, A Rigal, C Lazdunski, H Bénédetti. Role of TolR N-terminal, central, and C-terminal domains in dimerization and interaction with TolA and tolQ.. Journal of Bacteriology, American Society for Microbiology, 1999, 181 (15), pp.4476-84. ⟨hal-02130149⟩
  • Chantal Abergel, E. Bouveret, J.M Claverie, K Brown, A Rigal, et al.. Structure of the Escherichia coli TolB protein determined by MAD methods at 1.95 A resolution.. Structure, Elsevier (Cell Press), 1999, 7 (10), pp.1291-300. ⟨hal-02130130⟩
  • C.J Lazdunski, E. Bouveret, A. Rigal, L. Journet, R Lloubès, et al.. Colicin import into Escherichia coli cells.. Journal of Bacteriology, American Society for Microbiology, 1998, 180 (19), pp.4993-5002. ⟨hal-02130152⟩
  • E Bouveret, A Rigal, C Lazdunski, H Bénédetti. Distinct regions of the colicin A translocation domain are involved in the interaction with TolA and TolB proteins upon import into Escherichia coli.. Molecular Microbiology, Wiley, 1998, 27 (1), pp.143-57. ⟨hal-02130155⟩
  • Chantal Abergel, A Rigal, S Chenivesse, C Lazdunski, J.M Claverie, et al.. Crystallization and preliminary crystallographic study of a component of the Escherichia coli tol system: TolB.. Acta Crystallographica Section D: Biological Crystallography, International Union of Crystallography, 1998, 54 (Pt 1), pp.102-4. ⟨hal-02130160⟩
  • A Rigal, E. Bouveret, R Lloubes, C Lazdunski, H Bénédetti. The TolB protein interacts with the porins of Escherichia coli.. Journal of Bacteriology, American Society for Microbiology, 1997, 179 (23), pp.7274-7279. ⟨10.1128/jb.179.23.7274-7279.1997⟩. ⟨hal-02130169⟩
  • E Bouveret, A Rigal, C Lazdunski, H Bénédetti. The N-terminal domain of colicin E3 interacts with TolB which is involved in the colicin translocation step.. Molecular Microbiology, Wiley, 1997, 23 (5), pp.909-20. ⟨hal-02130173⟩
  • R Derouiche, M Gavioli, H Bénédetti, A Prilipov, C Lazdunski, et al.. TolA central domain interacts with Escherichia coli porins.. EMBO Journal, EMBO Press, 1996, 15 (23), pp.6408-15. ⟨hal-02130175⟩
  • Jean Claude Lazzaroni, Anne Vianney, V Vianney, Jean Luc Popot, Hélène Bénédetti, et al.. Transmembrane α-Helix Interactions are Required for the Functional Assembly of theEscherichia coliTol Complex. Journal of Molecular Biology, Elsevier, 1995, 246 (1), pp.1-7. ⟨10.1006/jmbi.1994.0058⟩. ⟨hal-02130202⟩
  • D. Duche, L. Letellier, V Géli, H Bénédetti, D. Baty. Quantification of group A colicin import sites.. Journal of Bacteriology, American Society for Microbiology, 1995, 177 (17), pp.4935-4939. ⟨10.1128/jb.177.17.4935-4939.1995⟩. ⟨hal-02130183⟩
  • D. Duche, L. Letellier, V. Geli, H. BÉnÉdetti, D. Baty. Quantification of group A colicin import sites.. Journal of Bacteriology, American Society for Microbiology, 1995, 177 (17), pp.4935-4939. ⟨10.1128/jb.177.17.4935-4939.1995⟩. ⟨hal-02440962⟩
  • E. Bouveret, R Derouiche, R. Rigal, R Lloubès, C Lazdunski, et al.. Peptidoglycan-associated lipoprotein-TolB interaction. A possible key to explaining the formation of contact sites between the inner and outer membranes of Escherichia coli. Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 1995, 270 (19), pp.11071-11077. ⟨10.1074/jbc.270.19.11071⟩. ⟨hal-02130195⟩
  • R Derouiche, H Bénédetti, Jc Lazzaroni, C Lazdunski, R Lloubès. Protein complex within Escherichia coli inner membrane. TolA N-terminal domain interacts with TolQ and TolR proteins. Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 1995, 270 (19), pp.11078-11084. ⟨10.1074/jbc.270.19.11078⟩. ⟨hal-02130187⟩
  • H Bénédetti, S Raths, F Crausaz, H. Riezman. The END3 gene encodes a protein that is required for the internalization step of endocytosis and for actin cytoskeleton organization in yeast.. Molecular Biology of the Cell, American Society for Cell Biology, 1994, 5 (9), pp.1023-37. ⟨hal-02130204⟩
  • G. Guihard, P. Boulanger, H Bénédetti, R Lloubés, M Besnard, et al.. Colicin A and the Tol proteins involved in its translocation are preferentially located in the contact sites between the inner and outer membranes of Escherichia coli cells.. Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 1994, 269 (8), pp.5874-80. ⟨hal-02130218⟩
  • David Espesset, Yves Corda, Kyle Cunningham, Hélène Bénédetti, Roland Lloubes, et al.. The colicin A pore-forming domain fused to mitochondrial intermembrane space sorting signals can be functionally inserted into the Escherichia coli plasma membrane by a mechanism that bypasses the Tol proteins. Molecular Microbiology, Wiley, 1994, 13 (6), pp.1121-1131. ⟨10.1111/j.1365-2958.1994.tb00503.x⟩. ⟨hal-02130213⟩
  • J Rohrer, H Bénédetti, B Zanolari, H. Riezman. Identification of a novel sequence mediating regulated endocytosis of the G protein-coupled alpha-pheromone receptor in yeast.. Molecular Biology of the Cell, American Society for Cell Biology, 1993, 4 (5), pp.511-21. ⟨hal-02130242⟩
  • G. Guihard, H Bénédetti, M Besnard, L. Letellier. Phosphate efflux through the channels formed by colicins and phage T5 in Escherichia coli cells is responsible for the fall in cytoplasmic ATP.. Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 1993, 268 (24), pp.17775-80. ⟨hal-02130233⟩
  • V Geli, R Lloubes, S Zaat, R van Spaendonk, C Rollin, et al.. Recognition of the colicin A N-terminal epitope 1C11 in vitro and in vivo in Escherichia coli by its cognate monoclonal antibody. FEMS Microbiology Letters, Wiley-Blackwell, 1993, 109 (2-3), pp.335-342. ⟨10.1016/0378-1097(93)90042-z⟩. ⟨hal-02130222⟩
  • Hélène Bénédetti, R Lloubès, C Lazdunski, L. Letellier. Colicin A unfolds during its translocation in Escherichia coli cells and spans the whole cell envelope when its pore has formed.. EMBO Journal, EMBO Press, 1992, 11 (2), pp.441-7. ⟨hal-02130272⟩
  • M Frenette, H Bénédetti, A. Bernadac, D. Baty, C Lazdunski. Construction, expression and release of hybrid colicins.. Journal of Molecular Biology, Elsevier, 1991, 217 (3), pp.421-8. ⟨hal-02130287⟩
  • Hélène Bénédetti, M Frenette, D. Baty, M Knibiehler, F. Pattus, et al.. Individual domains of colicins confer specificity in colicin uptake, in pore-properties and in immunity requirement.. Journal of Molecular Biology, Elsevier, 1991, 217 (3), pp.429-39. ⟨hal-02130283⟩
  • Hélène Bénédetti, C Lazdunski, R Lloubès. Protein import into Escherichia coli: colicins A and E1 interact with a component of their translocation system.. EMBO Journal, EMBO Press, 1991, 10 (8), pp.1989-95. ⟨hal-02130277⟩
  • D. Baty, F. Pattus, M. Parker, H. BÉnÉdetti, M. Frenette, et al.. Uptake across the cell envelope and insertion into the inner membrane of ion channel-forming colicins in E coli. Biochimie, Elsevier, 1990, 72 (2-3), pp.123-130. ⟨10.1016/0300-9084(90)90137-6⟩. ⟨hal-02130296⟩
  • C. Lazdunski, H Bénédetti. Insertion and translocation of proteins into and through membranes.. FEBS Letters, Wiley, 1990, 268 (2), pp.408-14. ⟨hal-02130669⟩
  • H. BÉnÉdetti, M. Frenette, D. Baty, R Lloubès, V. Geli, et al.. Comparison of the Uptake Systems for the Entry of Various BtuB Group Colicins into Escherichia coli. Microbiology, Microbiology Society, 1989, 135 (12), pp.3413-3420. ⟨10.1099/00221287-135-12-3413⟩. ⟨hal-02130300⟩

Communication dans un congrès

  • Wassim Lakhal, Nathalie Boizot, Marie-Claude Lesage Descauses, Odile Rogier, Véronique Laine-Prade, et al.. Both ChIP-SEQ and in planta gene modification demonstrate the involvement of MYB090 and MYB156 in secondary cell wall formation in poplar. INUPRAG-Meeting 2015, Oct 2015, Nancy, France. ⟨hal-01604786⟩
  • J. Tastet, P. Vourc'H, F. Laumonnier, C. Michelle, Anne Duittoz, et al.. Expression des isoformes de LIM Kinase 2 pendant la neurogenèse et la stimulation des neurones. 22. Colloque Biotechnocentre, Oct 2009, Seillac, France. ⟨hal-02753426⟩

Poster

  • Hélène Bénédetti, Fabienne Godin, Michel Doudeau, Béatrice Vallée, Marie-Ludivine De Tauzia, et al.. LINGO-1, a protein involved in various neurodevelopmental processes, interacts with neurofibromin (Nf1), the protein responsible for neurofibromatosis type I: molecular studies and functional implications. 10 th FENS (Forum of Neuroscience), Jul 2016, Copenhague, Denmark. ⟨hal-02453487⟩
  • Béatrice Vallée, Hélène Cuberos, Michel Doudeau, Fabienne Godin, Patrick Vourc’h, et al.. The three isoforms of human LIMK2 regulate actin cytoskeleton remodeling via different pathways. EMBL Symposium, Actin in action: From Molecules to Cellular Functions, Sep 2016, Heidelberg, Germany. ⟨hal-02453489⟩
  • Béatrice Vallée, Hélène Cuberos, Julie Tastet, Michel Doudeau, Fabienne Godin, et al.. LIMK2-1, a new primate-specific isoform of LIMK2, is associated with intellectual disability. 10 th FENS (Forum of Neurosciences), Jul 2016, Copenhague, Denmark. ⟨hal-02453486⟩
  • Béatrice Vallée, Michel Doudeau, Fabienne Godin, Anthony Champiré, Karen Plé, et al.. LIM kinases: new therapeutic targets to treat Neurofibromatosis type I. The 7th EMBO meeting, Sep 2016, Mannheim, Germany. ⟨hal-02453490⟩
  • Annabelle Dejardin, Wassim Lakhal, Nathalie Boizot, Marie-Claude Lesage Descauses, Odile Rogier, et al.. Unraveling the function of MYB090 and MYB156 in secondary cell wall formation in poplar using both ChIP-SEQ and in planta gene modification approach. 14. Cell Wall Meeting, Jun 2016, Chania, Grèce. 2016, XIV Cell Wall Meeting. Programme and Book of Abstracts. ⟨hal-02740921⟩

Chapitre d'ouvrage

  • H. BÉnÉdetti, V. Geli. Colicin transport, channel formation and inhibition. Handbook of Biological Physics, pp.665-691, 1996. ⟨hal-02130677⟩
  • Emmanuelle Bouveret, Claude Lazdunski, Hélène Bénédetti. The Tol/PAL and TonB systems : two envelope-spanning protein complexes involved in colicin import in E. coli.. Molecular Dynamics of Biomembranes, Springer Berlin Heidelberg, pp.59-69, 1996. ⟨hal-02130680⟩
  • Vincent Géli, Hélène Bénédetti. Insertion of Proteins into Membranes A Survey. Membrane biogenesis, pp.21-69, 1994, Subcellular Biochemistry, 978-1-4613-6018-6. ⟨hal-02130265⟩
  • C. Lazdunski, D. Baty, V. Geli, R. Lloubes, H. BÉnÉdetti, et al.. Molecular Mechanism of Action of Pore-Forming Colicins and of their Immunity Proteins. Membrane Proteins: Structures, Interactions and Models, pp.413-425, 1992. ⟨hal-02130675⟩
  • Hélène Bénédetti, Lucienne Letellier, Roland Lloubes, Vincent Géli, Daniel Baty, et al.. Study of the Import Mechanisms of Colicins Through Protein Engineering and K+ Efflux Kinetics. Bacteriocins, Microcins and Lantibiotics, Springer Berlin Heidelberg, pp.215-223, 1992. ⟨hal-02130674⟩
  • Hélène Bénédetti, Lucienne Letellier, Roland Lloubes, Vincent Géli, Daniel Baty, et al.. Import of Colicins into Escherichia Coli. Dynamics of Membrane Assembly, 63, Springer Berlin Heidelberg, pp.315-332, 1992. ⟨hal-02130670⟩
  • L. Letellier, C. Lazdunski, H. BÉnÉdetti, J. Bourdineaud, P. Boulanger. In Vivo Properties of Colicin A: Channel Activity and Translocation. Bacteriocins, Microcins and Lantibiotics, Springer Berlin Heidelberg, pp.119-125, 1992. ⟨hal-02130671⟩

Brevet

  • Sylvain Routier, Hélène Bénédetti, Frederic Buron, Marie-Aude Hiebel, Thibault Saurat, et al.. TRISUBSTITUTED PYRIDO[2,3-D]PYRIMIDINES, METHODS FOR PREPARING SAME AND THERAPEUTIC USES THEREOF. France, Patent n° : WO2014027081. 2014. ⟨hal-02131560⟩
  • Séverine Morisset-Lopez, Hélène Bénédetti. TOOLS FOR THE IDENTIFICATION OF LINGO-1, LINGO-2, LINGO-3 AND LINGO-4, LIGANDS, AND USES THEREOF. France, Patent n° : WO2011121257. 2011. ⟨hal-02130935⟩