Accueil > Publications > Recherche par années > Années 1990 > 1991

Hau, JF ; Asseline, U ; Thuong, NT

Octathymidylates involving alternating neopentylphosphothionotriester-phosphodiester linkages with controlled stereochemistry at the modified P-center

Tetrahedron Letters 32 (22) 2497-2498

par Administrateur - publié le

Abstract :

Starting from each pure stereoisomer of neopentylphosphothionotriester dimer, octathymidylates involving alternating stereoregular neopentylphosphothionotriester-phosphodiester linkages and covalently linked to an acridine derivative at their 3’-end have been synthesized. Their stability towards nuclease degradation was studied by comparison with an octanucleotide-acridine conjugate containing only phosphodiester groups.