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Accueil > Publications > Recherche par années > Années 1990 > 1993

Vinogradov, S ; Asseline, U ; Thuong, NT

Synthesis and physicochemical studies of partially phosphate-methylated oligodeoxyribonucleotides

Tetrahedron Letters 34 (37) 5899-5902

par Administrateur - publié le

Abstract :

Partially phosphate-methylated oligodeoxyribonucleotides have been synthesized on an oxalyl-CPG derivatized support using an isopropoxyacetyl group for the protection of the exocyclic amine of the nucleic bases. Hybridization properties with the target sequence have been studied by absorption spectroscopy.