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Asseline, U ; Thuong, NT

5’-5’-tethered oligonucleotides via nucleic bases - a potential new set of compounds for alternate strand triple-helix formation

Tetrahedron Letters 35 (29) 5221-5224

par Administrateur - publié le

Abstract :

The solid-phase synthesis of 5’-5’-linked oligonucleotides tethered via nucleic bases and with opposite polarities has been performed using a modified dinucleoside bearing a phosphoramidite group at the 3’-position of one nucleoside and a dimethoxytrityl group at the 3’-position of the second nucleoside.