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Accueil > Publications > Recherche par années > Années 1990 > 1994

Loubinoux, I ; Meric, P ; Borredon, J ; Correze, JL ; Gillet, B ; Beloeil, JC ; Tiffon, B ; Mispelter, J ; Lhoste, JM ; Jacques, S

Cerebral metabolic changes induced by MK-801 - a 1D (phosphorus and proton) and 2D (proton) in vivo NMR-spectroscopy study

Brain Research 643 (1-2) 115-124

par Administrateur - publié le

Abstract :

The dynamic effects of the non-competitive NMDA receptor antagonist, MK-801 on brain metabolism were investigated over 105 minutes in unanesthetized rats by proton and phosphorus NMR spectroscopy. MK-801 (0.5 and 5 mg/kg, i.p) induced no changes in intracellular pH, and in phosphocreatine, ATP, and inorganic phosphate levels, indicating that the drug preserved energy and intracellular pH homeostasis. There were transient increases in lactate after both doses of MK-801, suggesting early activation of glycolysis, which was not immediately matched by enhanced oxidative metabolism or by enhanced brood flow. Thereafter, lactate control level was not restored after 0.5 mg/kg whereas it was restored after 5 mg/kg in spite of a sustained metabolic activation.