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Accueil > Publications > Recherche par années > Années 1990 > 1994

Truffert, JC ; Lorthioir, O ; Asseline, U ; Thuong, NT ; Brack, A

On-line solid phase synthesis of oligonucleotide-peptide hybrids using silica supports

Tetrahedron Letters 35 (15) 2353-2356

par Administrateur - publié le

Abstract :

A procedure for the preparation of oligonucleotide-peptide hybrid molecules by means of automated synthesis is described. The conjugates have been assembled on silica supports including CPG (Controlled Pore Glass) and Fractosil supports. The novel N-epsilon-lysine protecting group, 1-(3,4-dimethyl-2,6-dioxocyclohex-1-ylidene) ethyl (Dde) was used.