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Lehmann, M ; Rabenandrasana, C ; Tamura, R ; Lissitzky, Jc ; Quaranta, V ; Pichon, J ; Marvaldi, J

A monoclonal-antibody inhibits adhesion to fibronectin and vitronectin of a colon-carcinoma cell-line and recognizes the integrins a ;(v)ß(3), a ;(v)ß(5), and a ;(v)ß(6)

Cancer Research 54 (8) 2102-2107

par Administrateur - publié le

Abstract :

Using whole viable human colon carcinoma HT29 cells as immunogen, we produced a monoclonal antibody (mAb) termed 69-6-5. The antibody was functionally selected on its anti-cell-spreading activity. By immunoprecipitation of surface radiolabeled cell lysates from HT29-D4 cells (an HT29 cell clone), mAb 69-6-5 recognized a molecular complex resembling integrin heterodimers.