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Accueil > Publications > Recherche par années > Années 1990 > 1995

Potreau, D ; Gomez, JP ; Fares, N

Depressed transient outward current in single hypertrophied cardiomyocytes isolated from the right ventricle of ferret heart

Cardiovascular Research 30 440-448

par Administrateur - publié le

Abstract :

Objective : The aim of this study was to investigate transient outward potassium current (I-to) changes as a basis for the prolongation of the action potential associated with cardiac hypertrophy. Methods : Right ventricular hypertrophy was induced by chronic pulmonary artery constriction in adult male ferrets. After 4-6 weeks, hearts were excised and single myocytes were isolated from the right ventricles of banded and sham-operated (control) animals by enzymatic dissociation. I-to was recorded by means of the whole cell patch clamp technique. Results : Heart weight:body weight ratio and cell membrane capacitance, as indications of hypertrophy, were increased by 17% (P