Accueil > Publications > Recherche par années > Années 1990 > 1995

Harding, L ; Scott, RH ; Kellenberger, C ; Hietter, H ; Luu, B ; Beadle, DJ ; Bermudez, I

Inhibition of high voltage-activated CA2+ currents from cultured sensory neurons by a novel insect peptide

Journal of Receptor and Signal Transduction Research 15 (1-4) 355-364

par Administrateur - publié le

Abstract :

PMP-D2, a novel 35 amino acid peptide isolated from the brain of the locust Locusta migratoria, is localised specifically in neurosecretory cells and nerve tracts of the Pars intercerebralis. When PMP-D2 is applied onto rat sensory neurones it blocks high voltage-activated inward Ca2+ currents at concentrations ranging from 0.1 mu M to 10 mu M The inhibitory effect of PMP-D2 is more marked on the sustained inward Ca2+ current measured at the end of 100 ms voltage step commands than on the maximum inward Ca2+ current. These results suggests that PMP-D2 may differentially inhibit the two components of the high voltage-activated inward Ca2+ currents of rat sensory neurones.