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Accueil > Publications > Recherche par années > Années 1990 > 1995

Muriaux, Delphine ; Girard, Pierre-Marie ; Bonnet-Mathoniere, Benedicte ; Paoletti, Jacques

Dimerization of HIV-1-Lai RNA at low ionic strength : An autocomplementary sequence in the 5’ leader region is evidenced by an antisense oligonucleotide

Journal of Biological Chemistry 270 (14) 8209-8216

par Administrateur - publié le

Abstract :

Genomic human immunodeficiency virus type 1 (HIV-1) RNA consists of two identical RNA molecules joined noncovalently near their 5’ ends in a region called the dimer linkage structure (DLS). Previous work has shown that the putative DLS is localized in a 113-nucleotide domain encompassing the 5’ end of the gag gene. This region contains conserved purine tracks that are thought to mediate dimerization through purine quartets.