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Lorthioir, O ; Truffert, JC ; Sy, D ; Barbier, B ; Lelièvre, D ; Brack, A

Computer design, synthesis and hydrolytic activity of peptidic artificial ribonucleases.

Protein and Peptide Letters 3 (3) 153-160

par Administrateur - publié le

Abstract :

An RNA cleaving catalyst combined to an antisense DNA may represent a new approach for gene targeted therapy. As cleaving agents, we used basic polypeptides under the ß-sheet or a-helix conformations, Molecular modeling studies were used in an attempt to design a second generation of artificial ribonucleases, taking into account the three-dimensional arrangement of functional groups in the peptide/RNA complexes. Such computer aid in rational design processes appears as an original and promising approach.