Accueil > Publications > Recherche par années > Années 1990 > 1998

Sebrie, C ; Gillet, B ; Lefaucheur, JP ; Sebille, A ; Beloeil, JC

Mouse muscle regeneration : an in vivo 2D H-1 magnetic resonance spectroscopy (MRS) study

Febs Letters 423 (1) 71-74

par Administrateur - publié le

Abstract :

Muscle degeneration and regeneration were studied by 2D H-1 magnetic resonance spectroscopy (MRS) and histological examination, in an experimental model of muscle injury using a myotoxic snake venom, notexin, The injured muscles produced a very specific MRS signal, corresponding to a tri-unsaturated fatty acid (linolenic acid-like) signal, from day 2 to day 9 after injury, The combination of MRS with histology showed that this signal was associated with a mechanism occurring during myoblast fusion to form myotubes, 2D H-1 MRS is thus a useful non-invasive tool for detecting muscle regeneration in vivo. (C) 1998 Federation of European Biochemical Societies.