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Toth, E ; Connac, F ; Helm, L ; Adzamli, K ; Merbach, AE

O-17-NMR, EPR and NMRD characterization of [Gd(DTPA-BMEA)(H2O)] : A neutral MRI contrast agent

European Journal of Inorganic Chemistry (12) 2017-2021

par Administrateur - publié le

Abstract :

A study including variable-temperature and -pressure, multiple-field O-17 NMR, EPR and NMRD has been performed on the MRI contrast agent, [Gd(DTPA-BMEA) (H2O)]. The water exchange rate [K-ex(298) = (0.39 +/- 0.02) x 10(6) s(-1)] and the activation volume (Delta V-not equal = +7.4 +/- 0.4 cm(3) mol(-1)), hence the mechanism, are identical to those for [Gd(DTPA-BMA)(H2O)]. The longer rotational correlation time of [Gd(DTPA-BMEA)(H2O)], as obtained from a global analysis of O-17-NMR, EPR and NMRD data, and compared to that of [Gd(DTPA-BMA)(H2O)], can be explained by water molecules hydrogen-bonded to the ether oxygen atoms of the ligand side chain.