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Accueil > Publications > Recherche par années > Années 1990 > 1998

Kieda, C

Role of lectin-glycoconjugate recognitions in cell-cell interactions leading to tissue invasion

Glycoimmunology 2 435 75-82

par Administrateur - publié le

Abstract :

Endogenous lectins are cell receptors, expressed in normal and transformed cells both circulating as well as in organized tissues. Their biological significance was shown in developmentally regulated processes of cell migration, embryonic maturation, differentiation and during various other normal and pathological processes. This work will focus on the role of endogenous lectins and their glycoconjugate ligands in homing of circulating normal and cancer cells. During the normal immune process of lymphocyte recirculation and their journey among the whole body through the secondary lymphoid organs in the search for antigen, lectins are decisive molecules that allow the very first interaction of arrest onto the endothelial cell layer. It has been demonstrated that dual lectin-glycoconjugate interactions were taking part in the initiation of the whole adhesion cascade between adhering and endothelial cell.