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Accueil > Publications > Recherche par années > Années 1990 > 1998

Arar, C ; Gaudin, JC ; Capron, L ; Legrand, A

Galectin-3 gene (LGALS3) expression in experimental atherosclerosis and cultured smooth muscle cells

Febs Letters 430 (3) 307-311

par Administrateur - publié le

Abstract :

The galectin-3 gene (LGALS3) encodes a ß-galactose binding lectin. LGALS3 expression is associated with neoplastic transformation and,vith differentiation of monocytes to macrophages. Factors involved in migration, proliferation, adhesion and differentiation of vascular smooth muscle cells (SMC) play a major role during atherosclerosis development, Expression of the galectin-3 gene was not detected in quiescent SMC but was activated in aortas of hypercholesterolemic rabbits, in aortas of rats after balloon injury and in cultured SMC. These results suggest that galectin-3 production is involved in the developmental process of atherogenesis. (C) 1998 Federation of European Biochemical Societies.