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Accueil > Publications > Recherche par années > Années 1990 > 1998

Gondeau, C ; Maurizot, JC ; Durand, M

Spectroscopic investigation of an intramolecular DNA triplex containing both G.G : C and T.A : T triads and its complex with netropsin

Journal of Biomolecular Structure & Dynamics 15 (6) 1133-1145

par Administrateur - publié le

Abstract :

The triple helix formation by the oligonucleotide (5’)d(G(4)T(4)G(4)- [T-4]-G(4)A(4)G(4)- [T-4]-C4T4C4) ([T-4] represents a stretch of 4 thymine residues) has been investigated by UV absorption spectroscopy and circular dichroism. In a 10 mM sodium cacodylate, 0.2 mM disodium EDTA (pH 7) buffer, we show : the following significant results :