Accueil > Publications > Recherche par années > Années 1990 > 1998

Bartholeyns, J ; Romet-Lemonne, JL ; Chokri, M ; Buyse, M ; Velu, T ; Bruyns, C ; Van de Winkel, JJ ; Heeney, J ; Koopman, G ; Malmsten, M ; De Groote, D ; Monsigny, M ; Midoux, P ; Alarcon, B

Cellular vaccines

Research in Immunology 149 (7-8) 647-649

par Administrateur - publié le

Abstract :

This project is devoted to the development of novel cellular vaccines designed to treat cancer patients. These cellular vaccines present and enhance immunogens, which will elicit a potent immune response. The goal is to achieve safe and effective immune reaction against the patient’s own tumour. (1) Autologous cellular vaccines are prepared by processing circulating brood mononuclear cells outside of the patient’s body (ex vivo) to differentiate them into antigen-presenting cells (APCs). Monocyte-derived APCs (MD-APCs) are then grown in the presence of exogenous target antigens (tumour cell debris, or apoptotic bodies) to become fully mature APCs. (2) Functionality for antigen presentation to T cells of ex vivo MD-APCs is evaluated in vivo. (3) Cellular vaccines are tested in selected rodent animal models. Efficiency and immune response are monitored in pertinent experimental systems for cancer. Pharmacological data are generated for clinical investigation.