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Accueil > Publications > Recherche par années > Années 1990 > 1998

Mollet, L ; Sadat-Sowti, B ; Duntze, J ; Leblond, V ; Bergeron, F ; Calvez, V ; Katlama, C ; Debre, P ; Autran, B

CD8(hi+)CD57(+) T lymphocytes are enriched in antigen-specific T cells capable of down-modulating cytotoxic activity

International Immunology 10 (3) 311-323

par Administrateur - publié le

Abstract :

Major expansions of CD8(hi+)CD57(+) T lymphocytes frequently occur during human immunodeficiency virus (HIV) infection and after transplantation. To investigate mechanisms of such cell expansion, we compared the activation and functional status of CD8(hi+)CD57(+) and CD57(-) peripheral blood lymphocytes (PBL) from normal, bone marrow transplantation (BMT) and HIV+ donors, The CD8(hi+)CD57(+) PBL from BMT and HIV+ donors preferentially displayed CD38 and HLA-DR activation markers without correlation between CD8(hi+)CD57(+) percentages and HIV load, the CD45RA(+) isoform in all ex vivo conditions but acquired CD45RO after in vitro expansion, CD11b and CD11c in BMT and HIV+ donors but decreased expression of CD62-L, VLA-2 and VLA-6.