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Nachtigal, M; Al-Assaad, Z; Mayer, EP; Kim, K; Monsigny, M

Galectin-3 expression in human atherosclerotic lesions

American Journal of Pathology 152 (5) 1199-1208

by Administrateur - published on


The expression of galectin-3, a ß-galactoside-binding lectin, was studied in atherosclerotic lesions from specimens obtained from carotid endarterectomies, lower limb amputations, and thoracic aortas from autopsies of young adult trauma victims, Immunohistochemical staining with the monoclonal antibody M3/38 demonstrated the presence of galectin-3 in advanced atherosclerotic lesions from each of 13 cases of carotid endarterectomy and 16 lower limb amputations and in the thoracic aorta of 4 of 20 cases of trauma victim adults, Immunostaining did not detect galectin-3 in umbilical cord and normal thoracic aorta arteries and limb veins.