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Accueil > Publications > Recherche par années > Années 1990 > 1998

Carriere, F ; Withers-Martinez, C ; van Tilbeurgh, H ; Roussel, A ; Cambillau, C ; Verger, R

Structure-function relationships of pancreatic lipases

Fett-Lipid 100 (4-5) 96-102

par Administrateur - publié le

Abstract :

The classical human pancreatic lipase (HPL) and the guinea pig pancreatic lipase-related protein 2 (GPLRP2) illustrate interesting steps in the molecular evolution of the pancreatic lipase gene family towards different substrate selectivities. Based on the known 3D structures of HPL and a GPLRP2 chimera, we review here the structural features and the kinetic properties of these two enzymes for a better understanding of their structure-function relationships.