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Jouvensal, L ; Carlier, PG ; Bloch, G

Evidence for Bi-exponential transverse relaxation of lactate in excised rat muscle

Magnetic Resonance in Medicine 41 (3) 624-626

par Administrateur - publié le

Abstract :

To elucidate the low proton nuclear magnetic resonance (NMR) visibility of muscle lactate previously demonstrated in excised rat muscle, lactate transverse relaxation was investigated in, the same model using double quantum editing sequences with effective echo times ranging from 55 to 475 msec. On this time scale, muscle lactate clearly exhibits a bi-exponential transverse relaxation with a short T-2 of 33 +/- 5 msec (mean +/- SE, n = 3) and a long T-2 of 230 +/- 10 msec. The relative populations (84 +/- 4% vs. 16 +/- 4%, respectively) of these two lactate pools are compatible with compartmentation between intra- and extracellular muscle lactate. Magn Reson Med 41:624-626, 1999. (C) 1999 Wiley-Liss, Inc.