Accueil > Publications > Recherche par années > Années 1990 > 1999

Carpentier, M ; Descamps, L ; Allain, F ; Denys, A ; Durieux, S ; Fenart, L ; Kieda, C ; Cecchelli, R ; Spik, G

Receptor-mediated transcytosis of cyclophilin B through the blood-brain barrier

Journal of Neurochemistry 73 (1) 260-270

par Administrateur - publié le

Abstract :

Cyclophilin B (CyPB) is a cyclosporin A (CsA)binding protein mainly located in intracellular vesicles and secreted in biological fluids. In previous works, we demonstrated that CyPB interacts with T lymphocytes and enhances in vitro cellular incorporation and activity of CsA, In addition to its immunosuppressive activity, CsA is able to promote regeneration of damaged peripheral nerves. However, the crossing of the drug from plasma to neural tissue is restricted by the relative impermeability of the blood-brain barrier, To know whether CyPB might also participate in the delivery of CsA into the brain, we have analyzed the interactions of CyPB with brain capillary endothelial cells.