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Accueil > Publications > Recherche par années > Années 1990 > 1999

Malinge, JM ; Giraud-Panis, MJ ; Leng, M

Interstrand cross-links of cisplatin induce striking distortions in DNA

Journal of Inorganic Biochemistry 77 (1-2) 23-29

par Administrateur - publié le

Abstract :

In the reaction between cellular DNA and cisplatin, different bifunctional adducts are formed including intrastrand and interstrand crosslinks. The respective role of these lesions in the cytotoxicity of the drug is not yet elucidated. This paper deals with the current knowledge on cisplatin interstrand cross-links and presents results on the formation, stability and structure of these adducts. A key step in the studies of these lesions is the recent determination of solution and crystallographic structures of double-stranded oligonucleotides containing a unique interstrand cross-link.