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Druillennec, S ; Meudal, H ; Roques, BP ; Fournie-Zaluski, MC

Nucleomimetic strategy for the inhibition of HIV-1 nucleocapsid protein NCp7 activities

Bioorganic & Medicinal Chemistry Letters 9 (4) 627-632

par Administrateur - publié le

Abstract :

We report the synthesis and biological properties of three modified dinucleotides T*G, G*T and T*T in winch the natural phosphodiester linkage has been replaced by a methylene carboxamide unit. They have been designed to act as nucleomimetics of a sequence recognized by the HIV-1 nucleocapsid protein NCp7 and to inhibit this interaction. (C) 1999 Elsevier Science Ltd. All rights reserved.