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Decoville, M ; Giraud-Panis, MJ ; Mosrin-Huaman, C ; Leng, M ; Locker, D

HMG boxes of DSP1 protein interact with the Rel homology domain of transcription factors

Nucleic Acids Research 28 (2) 454-462

par Administrateur - publié le , mis à jour le

Abstract :

Formation of the dorsoventral axis in Drosophila melanogaster is mediated through control of the expression of several genes by the morphogen Dorsal. In the ventral part of the embryo Dorsal activates twist and represses ren amongst others, Recently, several proteins have been shown to assist Dorsal in the repression of ten, one of which is DSP1, a HMG box protein that was isolated as a putative co-repressor of Dorsal. In this report we used a DSP1 null mutant to ascertain in vivo the involvement of DSP1 in Dorsal-mediated repression of ten but not in the activation of twist.