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Lugardon, K ; Raffner, R ; Goumon, Y ; Corti, A ; Delmas, A ; Bulet, P ; Aunis, D ; Metz-Boutigue, MH

Antibacterial and antifungal activities of vasostatin-1, the N-terminal fragment of chromogranin A

Journal of Biological Chemistry 275 (15) 10745-10753

par Administrateur - publié le

Abstract :

Vasostatin-1, the natural N-terminal 1-76 chromogranin A (CGA)-derived fragment in bovine sequence, has been purified from chromaffin secretory granules and identified by sequencing and matrix-assisted laser desorption time-of-flight mass spectrometry. This peptide, which displays antibacterial activity against Gram-positive bacteria at micromolar concentrations, is also able to kill a large variety of filamentous fungi and yeast cells in the 1-10 mu M range. We have found that the C-terminal moiety of vasostatin-1 is essential for the antifungal activity, and shorter active peptides have been synthesized.