Accueil > Publications > Recherche par années > Années 2000 > 2000

Gomez, JP ; Ghisdal, P ; Morel, N

Changes of the potassium currents in rat aortic smooth muscle cells during postnatal development

Pflügers Archives 441 388-397

par Administrateur - publié le

Abstract :

This study was designed to investigate the role and regulation of arterial K+ channels during postnatal development. Rat thoracic aortic segments were suspended for isometric tension and resting membrane potential (RMP) recording. Contraction in response to 4-aminopyridine (4-AP) was similar in 4-, 8- and 12-week-old rats but was higher in 1-day-old rats. Contraction in response to tetraethylammonium (TEA) increased after 4 weeks. TEA increased the contractions evoked by noradrenaline in the aorta from 8- and 12-week-old rats but not from 1-day- and 4-week-old rats. RMP did not change during development. Patch-clamp studies of freshly isolated smooth muscle cells from the same aortas bathed in Ca2+-free medium showed a voltage-dependent Kf current (IK) sensitive to 4-AP.