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Fajac, I ; Allo, JC ; Souil, E ; Merten, M ; Pichon, C ; Figarella, C ; Monsigny, M ; Briand, P ; Midoux, P

Histidylated polylysine as a synthetic vector for gene transfer into immortalized cystic fibrosis airway surface and airway gland serous cells

Journal of Gene Medicine 2 (5) 368-378

par Administrateur - publié le , mis à jour le

Abstract :

Background : We recently designed a cationic polymer called histidylated polylysine made of polylysine partially substituted with histidyl residues which become protonated at slightly acidic pH. This polymer is thought to induce the leakage of acidic vesicles containing plasmid/histidylated polylysine complexes.