Fajac, I ; Allo, JC ; Souil, E ; Merten, M ; Pichon, C ; Figarella, C ; Monsigny, M ; Briand, P ; Midoux, P
Journal of Gene Medicine 2 (5) 368-378
publié le , mis à jour le
Background : We recently designed a cationic polymer called histidylated polylysine made of polylysine partially substituted with histidyl residues which become protonated at slightly acidic pH. This polymer is thought to induce the leakage of acidic vesicles containing plasmid/histidylated polylysine complexes.