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Mollet, L ; Li, TS ; Samri, A ; Tournay, C ; Tubiana, R ; Calvez, V ; Debre, P ; Katlama, C ; Autran, B ; RESTIM COMET Study Grp

Dynamics of HIV-specific CD8(+) T lymphocytes with changes in viral load

Journal of Immunology 165 (3) 1692-1704

par Administrateur - publié le

Abstract :

The influence of HIV burden variations on the frequencies of Ag-specific CD8(+) T cell responses was evaluated before and during highly active antiretroviral therapy by analyzing the number, diversity, and function of these cells. The frequencies of HLA-A2-restricted CD8+ PBL binding HLA-A2/HIV-epitope tetramers or producing IFN-gamma were below 1%, A panel of 16 CTL epitopes covering 15 HLA class I molecules in 14 patients allowed us to test 3.8 epitopes/patient and to detect 2.2 +/- 1.8 HIV epitope-specific CD8(+) subsets per patient with a median frequency of 0.24% (0.11-4.79%).