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Lelièvre, D ; Bure, C ; Laot, F ; Delmas, A

Synthesis of peptide di-aldehyde precursor for stepwise chemoselective ligations via oxime bonds

Tetrahedron Letters 42 (2) 235-238

par Administrateur - publié le

Abstract :

To synthezise a triple-function branched peptide in a modular way, we present a new strategy based on orthogonal generation of two aldehyde functions from an acetal and a 2-amino alcohol. Successive unmaskings of aldehyde functions of the stem peptide affords stepwise chemoselective ligations of two (aminooxy)acetyl peptides via oxime bonds. (C) 2000 Elsevier Science Ltd. All rights reserved.