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Accueil > Publications > Recherche par années > Années 2000 > 2001

Mandard, N ; Labbe, H ; Da Silva, P ; Hetru, C ; Landon, C ; Vovelle, F

Role of disulfide bridges in the hairpin fold of androctonin. Structure-activity relationships.

Comptes Rendus de L Academie Des Sciences Serie Ii Fascicule C-Chimie 4 (10) 735-738

par Administrateur - publié le

Abstract :

Androctonin is a 25-residue antibacterial peptide extracted from the hemolymph of the scorpion Androctonus australis. In order to understand the structural requirements for hairpin fold and for interactions with the bacterial membrane, we have analysed the chemical shifts and the noes of three synthetic androctonin mutants for which the disulfide bridges were selectively removed. (C) 2001 Academie des sciences/Editions scientifiques et medicales Elsevier SAS.