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Bedouet, L ; Bousser, MT ; Frison, N ; Boccaccio, C ; Abastado, JP ; Marceau, P ; Mayer, R ; Monsigny, M ; Roche, AC

Uptake of dimannoside clusters and oligomannosides by human dendritic cells

Bioscience Reports 21 (6) 839-855

par Administrateur - publié le , mis à jour le

Abstract :

Knowing that human blood monocyte-derived dendritic cells express cell-surface mannose-specific lectins, we prepared various mannoses containing glycoconjugates with the aim of developing highly specific synthetic carriers of oligonucleotides and genes. Conjugates were prepared from oligosaccharides obtained by hydrazinolysis of Saccharomyces cerevisiae invertase glycopeptides.