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Accueil > Publications > Recherche par années > Années 2000 > 2001

Pichon, C ; Goncalves, C ; Midoux, P

Histidine-rich peptides and polymers for nucleic acids delivery

Advanced Drug Delivery Reviews 53 (1) 75-94

par Administrateur - publié le

Abstract :

Nucleic acids transfer into mammalian cells requires devices to improve their escape from endocytic vesicles where they are mainly confined following cellular uptake. In this review, we describe histidine-rich molecules that enable the transfer of plasmid and oligonucleotides (ODN) in human and non-human cultured cells. An histidine-rich peptide which permeabilizes biological membrane at pH 6.4, favored the transfection mediated by lactosylated polylysine/pDNA complexes.