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Montero, EI ; Perez, JM ; Schwartz, A ; Fuertes, MA ; Malinge, JM ; Alonso, C ; Leng, M ; Navarro-Ranninger, C

Apoptosis induction and DNA interstrand cross-link formation by cytotoxic trans-[PtCl2(NH(CH3)(2))(NHCH(CH3)(2))] : Cross-linking between d(G) and complementary d(C) within oligonucleotide duplexes

Chembiochem 3 (1) 61-67

par Administrateur - publié le

Abstract :

We have investigated the cytotoxic activity, the induction of apoptosis, and the interstrand cross-linking efficiency in the A2780cisR ovarian tumor cell line, after replacement of the two NH3 nonleaving groups in trans-[PtCl2(NH3)(2)] (trans-DDP) by dimethylamine and isopropylamine. The data show that trans-[PtCl2(NH(CH3)(2))(NHCH(CH3)(2))] is able to circumvent resistance to cis-[PtCl2(NH3)(2)] (cis-DDP, cisplatin) in A2780cisR cells.