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Aubert, Y ; Asseline, U

Synthesis and properties of oligonucleotides involving a perylene unit linked to a 2 ’-deoxyribose residue

Nucleosides Nucleotides & Nucleic Acids 22 (5-8) 1223-1225

par Administrateur - publié le

Abstract :

We report here the synthesis and binding properties of oligonucleotides involving a perylene unit linked to the anomeric position of a 2’-deoxyribose residue. Both anomers were separated and incorporated separately at either the 5’-end or the internal position of a pyrimidine sequence. In any case the presence of the perylene unit stabilizes the complexes formed with either the single or the double-stranded target.