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Muller, E ; Gasparutto, D ; Castaing, B ; Favier, A ; Cadet, J

Recognition of cyclonucleoside lesions by the Lactococcus lactis FPG protein

Nucleosides Nucleotides & Nucleic Acids 22 (5-8) 1563-1565

par Administrateur - publié le

Abstract :

Several purine and pyrimidine cyclonucleosides were found to be not recognized by several Escherichia coli and yeast DNA N-glycosylases. Interestingly, a non covalent complex was observed between the Lactoccocus lactis formamido-pyrimidine-DNA glycosylases (Fpg-L1) and the cyclonucleosides. This may provide new information on the mechanism involved in the activity of the latter enzyme.