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Kieda, C

How endothelial cell organo-specificity mediates circulating cell homing

Archivum Immunologiae et Therapiae Experimentalis 51 (2) 81-89

by Administrateur - published on


Normal and transformed cells home into tissues from the circulation in a very selective way thanks to highly complex molecular mechanisms that govern cell-to-cell interactions and drive the homing of circulating cells so that it is achieved properly. Because this is characterized by a resulting high selectivity, it constitutes a template for targeted drug-, gene- or cell-therapy strategies. Designing a mimetic-based therapy requires the identification of the responsible selective molecules, but also their mechanisms of action and interactions with their ligands together with their biological modulation and regulation. This homing/invasion event is decisive at the level of the endothelium that lines the vessel walls.