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Dus, D ; Krawczenko, A ; Zalecki, P ; Paprocka, M ; Wiedlocha, A ; Goupille, C ; Kieda, C

IL-7 receptor is present on human microvascular endothelial cells

Immunology Letters 86 (2) 163-168

par Administrateur - publié le

Abstract :

Interleukin-7 (IL-7) is a pleiotropic, non-redundant cytokine crucial for development of B and T lymphocytes. The cellular response to IL-7 is triggered by binding of the cytokine to its receptor, IL-7R. Until now the expression of the receptor was evidenced only in lymphoid and myeloid cell lineages. The receptor consists of two chains : IL-7 specific a chain (CD127) and the common 7. chain (CD132) which is a component of several other cytokine receptors : IL-2, IL-4, IL-9 and IL-15. The former observation that exogenous IL-7 is biologically active towards murine endothelial cell lines from secondary lymphoid organs was the starting point of our studies. This observation has prompted us to search for the presence of IL-7 receptor in human microvascular endothelial cells. We used in our studies a set of human endothelial cell lines established from various organs.