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Frison, N ; Taylor, ME ; Soilleux, E ; Bousser, MT ; Mayer, R ; Monsigny, M ; Drickamer, K ; Roche, AC

Oligolysine-based oligosaccharide clusters - Selective recognition and endocytosis by the mannose receptor and dendritic cell-specific intercellular adhesion molecule 3 (ICAM-3)-grabbing nonintegrin

Journal of Biological Chemistry 278 (26) 23922-23929

par Administrateur - publié le , mis à jour le

Abstract :

Dendritic cells are potent antigen-presenting cells that express several membrane lectins, including the mannose receptor and DC-SIGN ( dendritic cell-specific ICAM-3-grabbing nonintegrin). To identify highly specific ligands for these dendritic cell receptors, oligosaccharides were converted into glycosynthons (Os-1) and were used to prepare oligolysine-based glycoclusters, Os-[Lys(Os)](n)-Ala-Cys-NH2. Clusters containing two to six dimannosides as well as clusters containing four or five pentasaccharides (Lewis(a) or Lewis(x)) or hexasaccharides (Lewis(b)) were synthesized.