Accueil > Publications > Recherche par années > Années 2000 > 2004
Coste, F ; Ober, M ; Carell, T ; Boiteux, S ; Zelwer, C ; Castaing, B
Journal of Biological Chemistry 279 (42) 44074-44083
publié le
Abstract :
Formamidopyrimidine-DNA glycosylase (Fpg) is a DNA repair enzyme that excises oxidized purines such as 7,8-dihydro-8-oxoguanine (8-oxoG) and 2,6-diamino-4-hydroxy-5-formamidopyrimidine (FapyG) from damaged DNA. Here, we report the crystal structure of the Fpg protein from Lactococcus lactis (LlFpg) bound to a carbocyclic FapydG (cFapydG)-containing DNA.