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Fatin-Rouge, N ; Toth, E ; Meuli, R ; Bunzli, JCG

Enhanced Imaging Properties of a GdIII Complex with Unusually Large Relaxivity

Journal of Alloys and Compounds 374 (1-2) 298-302

par Administrateur - publié le

Abstract :

MRI contrast properties of self-aggregated nanoparticles made from Gd-III and 1,2,4,5-tetrakis(pyrazol-1-yl-methyl-3-carboxylate)benzene (L) are investigated. Viscosity of GdL2 suspensions and size-characteristics of GdL2 nanoparticles allow an estimate of their large rotational correlation time. Moreover, two to three H2O molecules are bound, on average, to Gd-III ions, as deduced from O-17 NMR titration of the Dy-III analogue. The large relaxivity of the particles, along with the prominent peak in the range 20-60 MHz, are the consequence of these two properties. Longitudinal (r(1)) and transverse (r(2)) relaxivities are determined as a function of monomer concentration at 20degreesC and 20 MHz. The ratio r(1)/r(2) appears to be favorable for MR imaging using T-1-weighted gradient echo sequences. According to preliminary tests conducted under physiological conditions, the GdL2 nanoparticles have some potential as contrast agent provided their stability can be increased. (C) 2003 Elsevier B.V. All rights reserved.