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Karmakova, T ; Feofanov, A ; Nazarova, A ; Grichine, A ; Yakubovskaya, R ; Luk’yanets, E ; Maurizot, JC ; Vigny, P

Distribution of metal-free sulfonated phthalocyanine in subcutaneously transplanted murine tumors

Journal of Photochemistry and Photobiology B-Biology 75 (1-2) 81-87

par Administrateur - publié le

Abstract :

Metal-free sulfonated phthalocyanine with the average number of sulfonate groups per molecule 2.4 (H2PcS2.4) was recently proved to be an efficient photosensitizer for the photodynamic therapy. Fluorescence spectral imaging microscopy was applied here to study localization and relative concentration of H2PcS2.4 with micron-scale resolution in subcutaneously transplanted murine tumors : Ehrlich mammary gland carcinoma (EC), Lewis lung carcinoma (LLC), P388 lymphoid leukemia (P388) and B16 melanoma (B16). The study of cryogenic tissue sections prepared 24 h after H2PcS2.4 intravenous injection revealed that H2PcS2.4 was present in all tissue structures in the monomeric photoactive state.