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Busca, P ; Piller, W ; Piller, F ; Martin, OR

Synthesis and biological evaluation of new UDP-GalNAc analogues for the study of polypeptide-alpha-GalNAc-transferases

Bioorganic & Medicinal Chemistry Letters 13 (11) 1853-1856

par Administrateur - publié le , mis à jour le

Abstract :

A series of three O-methylated UDP-GalNAc analogues have been synthesised using a divergent strategy from a 3,6-di-O-pivaloyl GlcNAc derivative. The biological activity of these probes toward polypeptide-alpha-GalNAc-transferase T1 has been investigated. This study shows that this glycosyltransferase exhibits a very high substrate specificity. (C) 2003 Elsevier Science Ltd. All rights reserved.